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RESEARCH ARTICLE (Open Access)

Challenges of providing HIV pre-exposure prophylaxis across Australian clinics: qualitative insights of clinicians

Anthony K J Smith https://orcid.org/0000-0002-0005-9542 A C , Bridget Haire B , Christy E. Newman A and Martin Holt A
+ Author Affiliations
- Author Affiliations

A Centre for Social Research in Health, UNSW Sydney, New South Wales, Australia.

B Kirby Institute, UNSW Sydney, New South Wales, Australia.

C Corresponding author. Email: anthony.smith@unsw.edu.au

Sexual Health 18(2) 187-194 https://doi.org/10.1071/SH20208
Submitted: 12 November 2020  Accepted: 1 March 2021   Published: 28 April 2021

Journal Compilation © CSIRO 2021 Open Access CC BY-NC

Abstract

Background: HIV pre-exposure prophylaxis (PrEP) has been rapidly implemented in Australia, initially through restricted access in demonstration studies, and then through prescribing across sexual health clinics and general practice settings. In 2018, PrEP was publicly subsidised for people with Medicare (universal health insurance for citizens, permanent residents and those from countries with reciprocal arrangements). There is little research examining the experiences of PrEP providers in Australia, and existing research has been primarily conducted before public subsidy. Methods: In this qualitative study, we examine the challenges that have emerged for PrEP-providing clinicians after public subsidy for PrEP was introduced. We conducted 28 semi-structured interviews in 2019–20 with PrEP providers in two Australian states, and analysed data thematically. Participants included general practitioners (GPs), sexual health nurses and sexual health physicians. Results: Sexual health services have been reconfigured to meet changing patient demand, with an emphasis on ensuring equitable financial access to PrEP. Restrictions to nurse-led PrEP frustrated some participants, given that nurses had demonstrated competence during trials. GPs were believed to be less effective at prescribing PrEP, but GP participants themselves indicated that PrEP was an easy intervention, but difficult to integrate into general practice. Participants expressed discomfort with on-demand PrEP. Conclusions: Our findings indicate that supporting ways for patients without Medicare to access PrEP inexpensively, advocating for nurse-led PrEP, and developing guidelines adapted to general practice consultations could ensure that PrEP is delivered more effectively and equitably. Additionally, PrEP providers require encouragement to build confidence in providing on-demand PrEP.

Keywords: access, general practice, healthcare provider, HIV prevention, nurses, on-demand PrEP, pre-exposure prophylaxis.


References

[1]  Holt M, Lee E, Lea T, Bavinton B, Broady T, Mao L, et al HIV Preexposure Prophylaxis Cascades to Assess Implementation in Australia: Results From Repeated, National Behavioral Surveillance of Gay and Bisexual Men, 2014–2018. J Acquir Immune Defic Syndr 2020; 83 e16–22.
HIV Preexposure Prophylaxis Cascades to Assess Implementation in Australia: Results From Repeated, National Behavioral Surveillance of Gay and Bisexual Men, 2014–2018.Crossref | GoogleScholarGoogle Scholar | 31913993PubMed |

[2]  Grulich AE, Guy R, Amin J, Jin F, Selvey C, Holden J, et al Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV pre-exposure prophylaxis in men who have sex with men: the EPIC-NSW prospective cohort study. Lancet HIV 2018; 5 e629–37.
Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV pre-exposure prophylaxis in men who have sex with men: the EPIC-NSW prospective cohort study.Crossref | GoogleScholarGoogle Scholar | 30343026PubMed |

[3]  Sexual Health and Blood-Borne Virus Applied Research & Evaluation Network. PrEPIT-WA Service Provider Evaluation: Final Activity Report. Perth: School of Public Health, Curtin University; 2019.

[4]  Zablotska IB, Selvey C, Guy R, Price K, Holden J, Schmidt H-M, et al Expanded HIV pre-exposure prophylaxis (PrEP) implementation in communities in New South Wales, Australia (EPIC-NSW): design of an open label, single arm implementation trial. BMC Public Health 2018; 18 210
Expanded HIV pre-exposure prophylaxis (PrEP) implementation in communities in New South Wales, Australia (EPIC-NSW): design of an open label, single arm implementation trial.Crossref | GoogleScholarGoogle Scholar | 29394918PubMed |

[5]  Lazarou M, Fitzgerald L, Warner M, Downing S, Williams OD, Gilks CF, et al Australian interdisciplinary healthcare providers’ perspectives on the effects of broader pre-exposure prophylaxis (PrEP) access on uptake and service delivery: a qualitative study. Sex Health 2020; 17 485–92.
Australian interdisciplinary healthcare providers’ perspectives on the effects of broader pre-exposure prophylaxis (PrEP) access on uptake and service delivery: a qualitative study.Crossref | GoogleScholarGoogle Scholar | 33292927PubMed |

[6]  Glover L. International Health Care System Profiles: Australia. The Commonwealth Fund. 2020. Available online at: https://www.commonwealthfund.org/international-health-policy-center/countries/australia

[7]  Australian Government Department of Health. Pharmaceutical Benefits: Fees, Patient Contributions and Safety New Thresholds. Pharmaceutical Benefits Scheme. 2020. Available online at: https://www.pbs.gov.au/info/healthpro/explanatory-notes/front/fee

[8]  PrEPAccessNow (PAN). PrEP 101. n.d. Available online at: https://www.pan.org.au/prep-101

[9]  The Australasian Society of HIV, Viral Hepatitis and Sexual Health Medicine (ASHM). PrEP Guidelines Update. Prevent HIV by Prescribing PrEP. 2019. Available online at: https://www.ashm.org.au/HIV/PrEP/

[10]  Pell C, Donohoe S, Conway D. Health Care Services for men who have sex with men in different Australian states and territories since the emergence of HIV. Sex Health 2008; 5 161
Health Care Services for men who have sex with men in different Australian states and territories since the emergence of HIV.Crossref | GoogleScholarGoogle Scholar | 18588781PubMed |

[11]  Newman CE, Persson A, Paquette DM, Kidd MR. The New Cultural Politics of the Waiting Room: Straight Men, Gay-Friendly Clinics and ‘Inclusive’ HIV Care. Sex Res Soc Policy 2013; 10 87–96.
The New Cultural Politics of the Waiting Room: Straight Men, Gay-Friendly Clinics and ‘Inclusive’ HIV Care.Crossref | GoogleScholarGoogle Scholar |

[12]  Hillis A, Germain J, Hope V, McVeigh J, Van Hout MC. Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Men Who Have Sex with Men (MSM): A Scoping Review on PrEP Service Delivery and Programming. AIDS Behav 2020; 24 3056–70.
Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Men Who Have Sex with Men (MSM): A Scoping Review on PrEP Service Delivery and Programming.Crossref | GoogleScholarGoogle Scholar | 32274670PubMed |

[13]  Pleuhs B, Quinn KG, Walsh JL, Petroll AE, John SA. Health Care Provider Barriers to HIV Pre-Exposure Prophylaxis in the United States: A Systematic Review. AIDS Patient Care STDS 2020; 34 111–23.
Health Care Provider Barriers to HIV Pre-Exposure Prophylaxis in the United States: A Systematic Review.Crossref | GoogleScholarGoogle Scholar | 32109141PubMed |

[14]  Silapaswan A, Krakower D, Mayer KH. Pre-Exposure Prophylaxis: A Narrative Review of Provider Behavior and Interventions to Increase PrEP Implementation in Primary Care. J Gen Intern Med 2017; 32 192–8.
Pre-Exposure Prophylaxis: A Narrative Review of Provider Behavior and Interventions to Increase PrEP Implementation in Primary Care.Crossref | GoogleScholarGoogle Scholar | 27761767PubMed |

[15]  Zhang C, McMahon J, Fiscella K, Przybyla S, Braksmajer A, LeBlanc N, et al HIV Pre-Exposure Prophylaxis Implementation Cascade Among Health Care Professionals in the United States: Implications from a Systematic Review and Meta-Analysis. AIDS Patient Care STDS 2019; 33 507–27.
HIV Pre-Exposure Prophylaxis Implementation Cascade Among Health Care Professionals in the United States: Implications from a Systematic Review and Meta-Analysis.Crossref | GoogleScholarGoogle Scholar | 31821044PubMed |

[16]  Lane W, Heal C, Banks J. HIV pre-exposure prophylaxis: Knowledge and attitudes among general practitioners. Aust J Gen Pract 2019; 48 722–7.
HIV pre-exposure prophylaxis: Knowledge and attitudes among general practitioners.Crossref | GoogleScholarGoogle Scholar | 31569318PubMed |

[17]  Smith AKJ, Holt M, Haire B, Newman CE. Issues Associated With Prescribing HIV Pre-exposure Prophylaxis for HIV Anxiety: A Qualitative Analysis of Australian Providers’ Views. J Assoc Nurses AIDS Care 2021; 32 94–104.
Issues Associated With Prescribing HIV Pre-exposure Prophylaxis for HIV Anxiety: A Qualitative Analysis of Australian Providers’ Views.Crossref | GoogleScholarGoogle Scholar | 33165182PubMed |

[18]  Holt M, Newman CE, Lancaster K, Smith AK, Hughes S, Truong H-HM. HIV pre-exposure prophylaxis and the ‘problems’ of reduced condom use and sexually transmitted infections in Australia: a critical analysis from an evidence-making intervention perspective. Sociol Health Illn 2019; 41 1535–48.
HIV pre-exposure prophylaxis and the ‘problems’ of reduced condom use and sexually transmitted infections in Australia: a critical analysis from an evidence-making intervention perspective.Crossref | GoogleScholarGoogle Scholar | 31215066PubMed |

[19]  Hope A, Haire B. “No-one’s driving this bus” - qualitative analysis of PrEP health promotion for Aboriginal and Torres Strait Islander gay and bisexual men. Aust N Z J Public Health 2019; 43 18–23.
“No-one’s driving this bus” - qualitative analysis of PrEP health promotion for Aboriginal and Torres Strait Islander gay and bisexual men.Crossref | GoogleScholarGoogle Scholar | 30516311PubMed |

[20]  Newman C, Hughes S, Persson A, Truong H-HM, Holt M. Promoting ‘Equitable Access’ to PrEP in Australia: Taking Account of Stakeholder Perspectives. AIDS Behav 2019; 23 1846–57.
Promoting ‘Equitable Access’ to PrEP in Australia: Taking Account of Stakeholder Perspectives.Crossref | GoogleScholarGoogle Scholar | 30306435PubMed |

[21]  Smith AKJ, Holt M, Hughes SD, Truong H-HM, Newman CE. Troubling the non-specialist prescription of HIV pre-exposure prophylaxis (PrEP): the views of Australian HIV experts. Health Sociol Rev 2020; 29 62–75.
Troubling the non-specialist prescription of HIV pre-exposure prophylaxis (PrEP): the views of Australian HIV experts.Crossref | GoogleScholarGoogle Scholar | 33411659PubMed |

[22]  Hoffman S, Guidry JA, Collier KL, Mantell JE, Boccher-Lattimore D, Kaighobadi F, et al A Clinical Home for Preexposure Prophylaxis: Diverse Health Care Providers’ Perspectives on the “Purview Paradox”. J Int Assoc Provid AIDS Care 2016; 15 59–65.
A Clinical Home for Preexposure Prophylaxis: Diverse Health Care Providers’ Perspectives on the “Purview Paradox”.Crossref | GoogleScholarGoogle Scholar | 26293904PubMed |

[23]  Krakower DS, Mayer KH. The role of healthcare providers in the roll out of preexposure prophylaxis. Curr Opin HIV AIDS 2016; 11 41–8.
The role of healthcare providers in the roll out of preexposure prophylaxis.Crossref | GoogleScholarGoogle Scholar | 26417953PubMed |

[24]  Przybyla S, LaValley S, St. Vil N. Health Care Provider Perspectives on Pre-exposure Prophylaxis: A Qualitative Study. J Assoc Nurses AIDS Care 2019; 30 630–8.
Health Care Provider Perspectives on Pre-exposure Prophylaxis: A Qualitative Study.Crossref | GoogleScholarGoogle Scholar | 30958406PubMed |

[25]  Sullivan PS, Siegler AJ. Getting pre-exposure prophylaxis (PrEP) to the people: opportunities, challenges and emerging models of PrEP implementation. Sex Health 2018; 15 522
Getting pre-exposure prophylaxis (PrEP) to the people: opportunities, challenges and emerging models of PrEP implementation.Crossref | GoogleScholarGoogle Scholar | 30476461PubMed |

[26]  Newman CE, de Wit JBF, Crooks L, Reynolds RH, Canavan PG, Kidd MR. Challenges of providing HIV care in general practice. Aust J Prim Health 2015; 21 164
Challenges of providing HIV care in general practice.Crossref | GoogleScholarGoogle Scholar | 24581265PubMed |

[27]  Newman CE, Kidd MR, Kippax SC, Reynolds RH, Canavan PG, de Wit JBF. Engaging nonHIV specialist general practitioners with new priorities in HIV prevention and treatment: qualitative insights from those working in the field. Sex Health 2013; 10 193
Engaging nonHIV specialist general practitioners with new priorities in HIV prevention and treatment: qualitative insights from those working in the field.Crossref | GoogleScholarGoogle Scholar | 23557634PubMed |

[28]  Clifford-Rashotte M, Fawcett N, Fowler B, Reinhart J, Tan DHS. Assessing the Potential for Nurse-Led HIV Pre- and Postexposure Prophylaxis in Ontario. Can J Nurs Res 2020;
Assessing the Potential for Nurse-Led HIV Pre- and Postexposure Prophylaxis in Ontario.Crossref | GoogleScholarGoogle Scholar | 32380845PubMed |

[29]  O’Byrne P, MacPherson P, Orser L, Jacob JD, Holmes D. PrEP-RN: Clinical Considerations and Protocols for Nurse-Led PrEP. J Assoc Nurses AIDS Care 2019; 30 301–11.
PrEP-RN: Clinical Considerations and Protocols for Nurse-Led PrEP.Crossref | GoogleScholarGoogle Scholar | 31008817PubMed |

[30]  Vanhamel J, Rotsaert A, Reyniers T, Nöstlinger C, Laga M, Van Landeghem E, et al The current landscape of pre-exposure prophylaxis service delivery models for HIV prevention: a scoping review. BMC Health Serv Res 2020; 20 704
The current landscape of pre-exposure prophylaxis service delivery models for HIV prevention: a scoping review.Crossref | GoogleScholarGoogle Scholar | 32736626PubMed |

[31]  Hopwood M, Newman C, Persson A, Watts I, de Wit J, Reynolds R, et al Expert perspectives on the contribution of HIV general practice nursing to the ‘extraordinary story’ of HIV medicine in Australia. Prim Health Care Res Dev 2014; 15 180–9.
Expert perspectives on the contribution of HIV general practice nursing to the ‘extraordinary story’ of HIV medicine in Australia.Crossref | GoogleScholarGoogle Scholar | 23506677PubMed |

[32]  Schmidt H-MA, McIver R, Houghton R, Selvey C, McNulty A, Varma R, et al Nurse-led pre-exposure prophylaxis: a non-traditional model to provide HIV prevention in a resource-constrained, pragmatic clinical trial. Sex Health 2018; 15 595
Nurse-led pre-exposure prophylaxis: a non-traditional model to provide HIV prevention in a resource-constrained, pragmatic clinical trial.Crossref | GoogleScholarGoogle Scholar |

[33]  Buckley T, Cashin A, Stuart M, Browne G, Dunn SV. Nurse practitioner prescribing practices: the most frequently prescribed medications. J Clin Nurs 2013; 22 2053–63.
Nurse practitioner prescribing practices: the most frequently prescribed medications.Crossref | GoogleScholarGoogle Scholar | 23346963PubMed |

[34]  Kirby Institute. HIV, viral hepatitis and sexually transmissible infections in Australia: annual surveillance report 2018. 2018. Available online at: https://kirby.unsw.edu.au/report-type/annual-surveillance-reports

[35]  Keen P, Bavinton BR. Could disparities in PrEP uptake limit the public health benefit? Lancet Public Health 2020; 5 e467–8.
Could disparities in PrEP uptake limit the public health benefit?Crossref | GoogleScholarGoogle Scholar | 32888440PubMed |

[36]  Walia AM, Fairley CK, Bradshaw CS, Chen MY, Chow EPF. Disparities in characteristics in accessing public Australian sexual health services between Medicare‐eligible and Medicare‐ineligible men who have sex with men. Aust N Z J Public Health 2020; 44 363–8.
Disparities in characteristics in accessing public Australian sexual health services between Medicare‐eligible and Medicare‐ineligible men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 32865864PubMed |

[37]  MacGibbon J, Lea T, Ellard J, Murphy D, Kolstee J, Power C, et al Access to subsidised healthcare affects HIV pre-exposure prophylaxis (PrEP) uptake among gay and bisexual men in Australia: results of national surveys 2013–19. J Acquir Immune Defic Syndr 2021; 86 430–5.
Access to subsidised healthcare affects HIV pre-exposure prophylaxis (PrEP) uptake among gay and bisexual men in Australia: results of national surveys 2013–19.Crossref | GoogleScholarGoogle Scholar | 33230031PubMed |

[38]  Molina J-M, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, et al On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection. N Engl J Med 2015; 373 2237–46.
On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection.Crossref | GoogleScholarGoogle Scholar | 26624850PubMed |

[39]  Wright E, Grulich A, Roy K, Boyd M, Cornelisse V, Russell D, et al Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines. Update April 2018. J Virus Erad 2018; 4 143–59.
Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines. Update April 2018.Crossref | GoogleScholarGoogle Scholar | 30050676PubMed |

[40]  Fraser D, Chan C, Vaccher S, Holt M, Prestage G, Zablotska-Manos I. et al. Report on the PrEP in NSW Transition Study, 2018–2020. 2020. Available online at: http://handle.unsw.edu.au/1959.4/unsworks_67663

[41]  MacGibbon J, Lea T, Ellard J, Murphy D, Bear B, Kolstee J. et al. Attitudes to biomedical HIV prevention among Australian gay and bisexual men: Key findings from the PrEPARE Project 2019. 2019. Available online at: http://handle.unsw.edu.au/1959.4/unsworks_61623

[42]  Power M, Lewis DA, Richardson D. On-demand HIV pre-exposure prophylaxis: what are the healthcare workers’ barriers to delivery in a culturally and linguistically diverse population? Sex Transm Infect 2020; 96 549
On-demand HIV pre-exposure prophylaxis: what are the healthcare workers’ barriers to delivery in a culturally and linguistically diverse population?Crossref | GoogleScholarGoogle Scholar | 31911427PubMed |

[43]  Zablotska IB, O’Connor CC. Preexposure Prophylaxis of HIV Infection: the Role of Clinical Practices in Ending the HIV Epidemic. Curr HIV/AIDS Rep 2017; 14 201–10.
Preexposure Prophylaxis of HIV Infection: the Role of Clinical Practices in Ending the HIV Epidemic.Crossref | GoogleScholarGoogle Scholar | 29071519PubMed |

[44]  Golub SA, Myers JE. Next-Wave HIV Pre-Exposure Prophylaxis Implementation for Gay and Bisexual Men. AIDS Patient Care STDS 2019; 33 253–61.
Next-Wave HIV Pre-Exposure Prophylaxis Implementation for Gay and Bisexual Men.Crossref | GoogleScholarGoogle Scholar | 31094576PubMed |

[45]  Braun V, Clarke V. Reflecting on reflexive thematic analysis. Qual Res Sport Exerc Health 2019; 11 589–97.
Reflecting on reflexive thematic analysis.Crossref | GoogleScholarGoogle Scholar |

[46]  Newman CE, de Wit JBF, Kippax SC, Reynolds RH, Canavan PG, Kidd MR. The role of the general practitioner in the Australian approach to HIV care: interviews with ‘key informants’ from government, non-government and professional organisations. Sex Transm Infect 2012; 88 132–5.
The role of the general practitioner in the Australian approach to HIV care: interviews with ‘key informants’ from government, non-government and professional organisations.Crossref | GoogleScholarGoogle Scholar | 22345027PubMed |

[47]  Persson A, Newman CE, Hopwood M, Kidd MR, Canavan PG, Kippax SC, et al No Ordinary Mainstream Illness: How HIV Doctors Perceive the Virus. Qual Health Res 2014; 24 6–17.
No Ordinary Mainstream Illness: How HIV Doctors Perceive the Virus.Crossref | GoogleScholarGoogle Scholar | 24259535PubMed |

[48]  Newman CE, Reynolds R, Gray R, Canavan P, De Wit J, McMurchie M, et al Surviving an epidemic – Australian GPs on caring for people with HIV and AIDS in the early years. Aust Fam Physician 2013; 42 734–8.
| 24130978PubMed |

[49]  Hayes R, Schmidt AJ, Pharris A, Azad Y, Brown AE, Weatherburn P, et al Estimating the ‘PrEP Gap’: how implementation and access to PrEP differ between countries in Europe and Central Asia in 2019. Euro Surveill 2019; 24
Estimating the ‘PrEP Gap’: how implementation and access to PrEP differ between countries in Europe and Central Asia in 2019.Crossref | GoogleScholarGoogle Scholar | 31615599PubMed |

[50]  Kay ES, Pinto RM. Is Insurance a Barrier to HIV Preexposure Prophylaxis? Clarifying the Issue. Am J Public Health 2020; 110 61–4.
Is Insurance a Barrier to HIV Preexposure Prophylaxis? Clarifying the Issue.Crossref | GoogleScholarGoogle Scholar | 31725314PubMed |

[51]  Douglass T, Calnan M. Trust matters for doctors? Towards an agenda for research. Soc Theory Health 2016; 14 393–413.
Trust matters for doctors? Towards an agenda for research.Crossref | GoogleScholarGoogle Scholar |

[52]  Arnold EA, Hazelton P, Lane T, Christopoulos KA, Galindo GR, Steward WT, et al A Qualitative Study of Provider Thoughts on Implementing Pre-Exposure Prophylaxis (PrEP) in Clinical Settings to Prevent HIV Infection. PLoS One 2012; 7 e40603
A Qualitative Study of Provider Thoughts on Implementing Pre-Exposure Prophylaxis (PrEP) in Clinical Settings to Prevent HIV Infection.Crossref | GoogleScholarGoogle Scholar | 22792384PubMed |

[53]  Reeves S, Lewin S, Espin S, Zwarenstein M. Interprofessional teamwork for health and social care. Oxford: Wiley-Blackwell; 2010.

[54]  King O, Nancarrow SA, Borthwick AM, Grace S. Contested professional role boundaries in health care: a systematic review of the literature. J Foot Ankle Res 2015; 8
Contested professional role boundaries in health care: a systematic review of the literature.Crossref | GoogleScholarGoogle Scholar | 25670968PubMed |