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Association Between Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Infertility Risk: Evidence From a Cross-Sectional Study

Huijuan Ni, Cuiping Cao

Abstract

This study explores the relationship between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility using data from 5,814 participants in the NHANES database. Multivariable logistic regression models were employed to assess the association while adjusting for potential confounders. The findings revealed a significant positive correlation between UHR and infertility risk, suggesting that higher UHR levels may contribute to an increased likelihood of infertility. A dose-response relationship was observed, further supporting the robustness of the association. Additionally, subgroup analyses were conducted to examine potential heterogeneity across different populations, and the results remained consistent, reinforcing the reliability of our conclusions. While the study provides valuable insights into the potential role of UHR in female reproductive health, the cross-sectional design limits causal inference. Future longitudinal studies are needed to confirm these findings and explore the underlying mechanisms.

SH24241  Accepted 04 July 2025

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