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Food, fibre and pharmaceuticals from animals
REVIEW

A review on biogenic amines in food and feed: toxicological aspects, impact on health and control measures

V. Feddern https://orcid.org/0000-0002-8678-2415 A B , H. Mazzuco A , F. N. Fonseca A and G. J. M. M. de Lima A
+ Author Affiliations
- Author Affiliations

A Embrapa Suínos e Aves, BR 153, km 110, 89715-899 Concórdia/SC, Brazil.

B Corresponding author. Email: vivian.feddern@embrapa.br

Animal Production Science 59(4) 608-618 https://doi.org/10.1071/AN18076
Submitted: 25 May 2017  Accepted: 7 January 2019   Published: 11 February 2019

Abstract

Biogenic amines (BAs) represent a considerable toxicological risk in some food and feed products. They are formed under unhygienic conditions during storage and processing; therefore, an increase in the concentrations of those metabolites is related to putrefaction. Because BAs are thermostable, they remain in food and feed that have undergone heat treatment. There are several toxicological effects, especially caused by histamine, when high concentrations of BAs are ingested by humans, depending on the food itself and also on individual susceptibility and individual health status. The present paper reviews the main BAs in meat products, their use as spoilage indicators, the risk on human health and also the contamination of by-product meals. Furthermore, we highlight the state of art regarding impact of BAs on poultry, meat and eggs.

Additional keywords: bioactive amines, by-products, human health, meat, poultry, rendering.


References

Alvarez MA, Moreno-Arribas MV (2014) The problem of biogenic amines in fermented foods and the use of potential biogenic amine-degrading microorganisms as a solution. Trends in Food Science & Technology 39, 146–155.
The problem of biogenic amines in fermented foods and the use of potential biogenic amine-degrading microorganisms as a solution.Crossref | GoogleScholarGoogle Scholar |

Assis DCS (2014) Aminas bioativas em carne de peito de frango e em ovos de consumo produzidos no estado de Minas Gerais. UFMG, Belo Horizonte, Brazil. Available at http://www.bibliotecadigital.ufmg.br/dspace/bitstream/handle/1843/SMOC-9PJHV2/d_bora_c._s._assis___aminas_bioativas_em_carne_de_peito_de_frango_e_em_ovos__de_consumo_produzidos_no_estado_de_minas_gerais.pdf?sequence=1 [Verified 23 January 2019]

Assis DCS, Menezes LDM, Silva GR, Caccioppoli J, Santos ELS, Heneine LGD, Figueiredo TC, Cançado SV (2015) Bioactive amines and meat quality of broiler chickens. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 67, 1729–1734.
Bioactive amines and meat quality of broiler chickens.Crossref | GoogleScholarGoogle Scholar |

Assis DCS, Menezes LDM, Lima AL, Klein RWT, Heneine LGD, Ornellas CBD, Figueiredo TC, Cançado SV (2016) Avaliação da qualidade interna de ovos de consumo pela pesquisa do teor de aminas bioativas [Evaluation of the internal quality of commercial eggs by searching of the bioactive levels]. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 68, 517–524.
Avaliação da qualidade interna de ovos de consumo pela pesquisa do teor de aminas bioativas [Evaluation of the internal quality of commercial eggs by searching of the bioactive levels].Crossref | GoogleScholarGoogle Scholar |

Badolo L, Gelbcke M, Dubois J, Hanocq M (1998) Synthesis and cytotoxicity studies of new analogues of polyamine. Die Pharmazie 53, 15–19.

Bardócz S (1995) Polyamines in food and their consequences for food quality and human health. Trends in Food Science & Technology 6, 341–346.
Polyamines in food and their consequences for food quality and human health.Crossref | GoogleScholarGoogle Scholar |

Barnes DM, Kirby YK, Oliver KG (2001) Effects of biogenic amines on growth and the incidence of proventricular lesions in broiler chickens. Poultry Science 80, 906–911.
Effects of biogenic amines on growth and the incidence of proventricular lesions in broiler chickens.Crossref | GoogleScholarGoogle Scholar | 11469653PubMed |

Belitz H-D, Grosch W, Schieberle P (2009) ‘Food chemistry.’ (Springer: Berlin)

Bermudez AJ, Firman JD (1998) Effects of biogenic amines in broiler chickens. Avian Diseases 42, 199–203.
Effects of biogenic amines in broiler chickens.Crossref | GoogleScholarGoogle Scholar | 9533102PubMed |

Bover-Cid S, Latorre-Moratalla ML, Veciana-Nogués MT, Vidal-Carou MC (2014) Processing contaminants: biogenic amines. Encyclopedia of Food Safety 2, 381–391.

Buňková L, Buňka F, Klčovská P, Mrkvička V, Doležalová M, Kráčmar S (2010) Formation of biogenic amines by Gram-negative bacteria isolated from poultry skin. Food Chemistry 121, 203–206.
Formation of biogenic amines by Gram-negative bacteria isolated from poultry skin.Crossref | GoogleScholarGoogle Scholar |

Cardozo M, Lima KSC, França TCC, Lima ALS (2013) Biogenic amines: a public health problem. Revista Virtual de Química 5, 149–168.
Biogenic amines: a public health problem.Crossref | GoogleScholarGoogle Scholar |

Dadáková E, Pelikánová T, Kalač P (2012) Contents of biologically active polyamines in duck meat and giblets after slaughter and their changes during meat storage and cooking. Food Research International 48, 28–33.
Contents of biologically active polyamines in duck meat and giblets after slaughter and their changes during meat storage and cooking.Crossref | GoogleScholarGoogle Scholar |

den Brinker CA, Rayner CJ, Kerr MG, Bryden WL (2003) Biogenic amines in Australian animal by-product meals. Australian Journal of Experimental Agriculture 43, 113–119.
Biogenic amines in Australian animal by-product meals.Crossref | GoogleScholarGoogle Scholar |

EFSA (2011) Scientific opinion on risk based control of biogenic amine formation in fermented foods. EFSA Journal 9, 1–93.
Scientific opinion on risk based control of biogenic amine formation in fermented foods.Crossref | GoogleScholarGoogle Scholar |

FAO/WHO (2005) ‘Code of hygienic practice for meat. CAC/RCP 58-2005 1–52.’ Available at http://www.codexalimentarius.org/input/download/standards/10196/CXP_058e.pdf [Verified 31 January 2018]

FAO/WHO (2009) ‘Animal food production.’ 2nd edn. (Codex Alimentarius Commission: Rome, Italy) Available at www.fao.org/docrep/012/i1111e/i1111e.pdf [Verified 31 January 2018]

FAO/WHO (2012) ‘Joint FAO/WHO expert meeting on the public health risks of histamine and other biogenic amines from fish and fishery products.’ (FAO: Rome)

FDA (2012) ‘Food and drug administration. Appendix 5: FDA and EPA safety levels in regulations and guidance.’ pp. 439–442. Available at http://www.fda.gov/downloads/Food/GuidanceRegulation/UCM252448.pdf [Verified 31 January 2018]

Figueiredo TC, Viegas RP, Lara LJC, Baião NC, Souza MR, Heneine LGD, Cançado SV (2013) Bioactive amines and internal quality of commercial eggs. Poultry Science 92, 1376–1384.
Bioactive amines and internal quality of commercial eggs.Crossref | GoogleScholarGoogle Scholar | 23571349PubMed |

Figueiredo TC, Assis DCS, Menezes LDM, Oliveira DD, Lima AL, Souza MR, Heneine LGD, Cançado SV (2014) Effects of packaging, mineral oil coating, and storage time on biogenic amine levels and internal quality of eggs. Poultry Science 93, 3171–3178.
Effects of packaging, mineral oil coating, and storage time on biogenic amine levels and internal quality of eggs.Crossref | GoogleScholarGoogle Scholar | 25306463PubMed |

Figueiredo TC, De Assis DCS, Menezes LDM, Da Silva GR, Lanza IP, Heneine LGD, Cançado SDV (2015) HPLC-UV method validation for the identification and quantification of bioactive amines in commercial eggs. Talanta 142, 240–245.
HPLC-UV method validation for the identification and quantification of bioactive amines in commercial eggs.Crossref | GoogleScholarGoogle Scholar | 26003718PubMed |

Firman JD (2006) Rendered products in poultry nutrition. In ‘Essential rendering’. (Ed. DL Meeker) pp. 125–139. (The National Renderers Association; The Fats and Proteins Research Foundation; The Animal Protein Producers Industry: Arlington, VA)

Friday ML, Firman JD, Bermudez AJ (1999) Effects of biogenic amines on broiler performance. Applied Poultry Science 8, 408–413.
Effects of biogenic amines on broiler performance.Crossref | GoogleScholarGoogle Scholar |

Galgano F, Favati F, Bonadio M, Lorusso V, Romano P (2009) Role of biogenic amines as index of freshness in beef meat packed with different biopolymeric materials. Food Research International 42, 1147–1152.
Role of biogenic amines as index of freshness in beef meat packed with different biopolymeric materials.Crossref | GoogleScholarGoogle Scholar |

Girdhar SR, Barta JR, Santoyo FA, Smith TK (2006) Dietary putrescine (1,4-diaminobutane) influences recovery of turkey poults challenged with a mixed coccidial infection. The Journal of Nutrition 136, 2319–2324.
Dietary putrescine (1,4-diaminobutane) influences recovery of turkey poults challenged with a mixed coccidial infection.Crossref | GoogleScholarGoogle Scholar | 16920848PubMed |

Gjevre A, Kaldhusdal M, Eriksen GS (2013) Gizzard erosion and ulceration syndrome in chickens and turkeys: a review of causal or predisposing factors. Avian Pathology 42, 297–303.
Gizzard erosion and ulceration syndrome in chickens and turkeys: a review of causal or predisposing factors.Crossref | GoogleScholarGoogle Scholar | 23859215PubMed |

Glória MBA (2006) Bioactive amines. In ‘Handbook of Food Science, Technology and Engineering’. (Ed. YH Hui) pp. 13-1–13-38. (Taylor & Francis: Boca Raton, FL)

Gomes MB, Pires BAD, Fracalanzza SAP, Marin VA (2014) The risk of biogenic amines in food. Ciencia & Saude Coletiva 19, 1123–1134.
The risk of biogenic amines in food.Crossref | GoogleScholarGoogle Scholar |

Guidi LR, Gloria MBA (2012) Bioactive amines in soy sauce: validation of method, occurrence and potential health effects. Food Chemistry 133, 323–328.
Bioactive amines in soy sauce: validation of method, occurrence and potential health effects.Crossref | GoogleScholarGoogle Scholar | 25683402PubMed |

Guo X, Guan X, Wang Y, Li L, Wu D, Chen Y, Pei H, Xiao D (2015) Reduction of biogenic amines production by eliminating the PEP4 gene in Saccharomyces cerevisiae during fermentation of Chinese rice wine. Food Chemistry 178, 208–211.
Reduction of biogenic amines production by eliminating the PEP4 gene in Saccharomyces cerevisiae during fermentation of Chinese rice wine.Crossref | GoogleScholarGoogle Scholar | 25704703PubMed |

Hui YH (2006) ‘Handbook of food science, technology and engineering.’ (Ed. YH Hui) (Taylor & Francis: Boca Raton, FL)

Hungerford JM (2010) Scombroid poisoning: a review. Toxicon 56, 231–243.
Scombroid poisoning: a review.Crossref | GoogleScholarGoogle Scholar | 20152850PubMed |

Jaw Y-M, Chen Y-Y, Lee Y-C, Lee P-H, Jiang C-M, Tsai Y-H (2012) Histamine content and isolation of histamine-forming bacteria in fish meal and fish soluble concentrate. Fisheries Science 78, 155–162.
Histamine content and isolation of histamine-forming bacteria in fish meal and fish soluble concentrate.Crossref | GoogleScholarGoogle Scholar |

Kalac P (2006) Biologically active polyamines in meat and liver and their implications for human nutrition. Feedinfo News Service: London.

Kalač P (2014) Health effects and occurrence of dietary polyamines: a review for the period 2005–mid 2013. Food Chemistry 161, 27–39.
Health effects and occurrence of dietary polyamines: a review for the period 2005–mid 2013.Crossref | GoogleScholarGoogle Scholar | 24837918PubMed |

Köse S, Quantick P, Hall G (2003) Changes in the levels of histamine during processing and storage of fish meal. Animal Feed Science and Technology 107, 161–172.
Changes in the levels of histamine during processing and storage of fish meal.Crossref | GoogleScholarGoogle Scholar |

Krausová P, Kalač P, Křížek M, Pelikánová T (2006) Content of biologically active polyamines in livers of cattle, pigs and chickens after animal slaughter. Meat Science 73, 640–644.
Content of biologically active polyamines in livers of cattle, pigs and chickens after animal slaughter.Crossref | GoogleScholarGoogle Scholar | 22062564PubMed |

Lázaro CA, Conte-Júnior CA, Cunha FL, Mársico ET, Mano SB, Franco RM (2013) Validation of an HPLC methodology for the identification and quantification of biogenic amines in chicken meat. Food Analytical Methods 6, 1024–1032.
Validation of an HPLC methodology for the identification and quantification of biogenic amines in chicken meat.Crossref | GoogleScholarGoogle Scholar |

Lee S, Yoo M, Shin D (2015) The identification and quantification of biogenic amines in Korean turbid rice wine, Makgeolli by HPLC with mass spectrometry detection. Lebensmittel–Wissenschaft + Technologie 62, 350–356.
The identification and quantification of biogenic amines in Korean turbid rice wine, Makgeolli by HPLC with mass spectrometry detection.Crossref | GoogleScholarGoogle Scholar |

Lehane L, Olley J (2000) Histamine fish poisoning revisited. International Journal of Food Microbiology 58, 1–37.
Histamine fish poisoning revisited.Crossref | GoogleScholarGoogle Scholar | 10898459PubMed |

Macan J, Turk R, Vukušić J, Kipčić D, Milković-Kraus S (2006) Long-term follow-up of histamine levels in a stored fish meal sample. Animal Feed Science and Technology 127, 169–174.
Long-term follow-up of histamine levels in a stored fish meal sample.Crossref | GoogleScholarGoogle Scholar |

MAPA (2011) ‘Instrução normativa SDA n°. 45, de 13 de Dezembro de 2011 [Normative instruction no. 45, from 13 December 2011].’ Aprova o Regulamento Técnico de Identidade e Qualidade de Conservas de Peixes. (Diário Oficial da União: Brasília, Brazil)

Meeker DL (2009) North American rendering: processing high quality protein and fats for feed. Revista Brasileira de Zootecnia 38, 432–440.
North American rendering: processing high quality protein and fats for feed.Crossref | GoogleScholarGoogle Scholar |

Meeker DL, Hamilton CR (2006) An overview of the rendering industry. ‘Essential rendering’. pp. 1–16. (The National Renderers Association; the Fats and Proteins Research Foundation; the Animal Protein Producers Industry: Arlington, VA)

Min JS, Lee SO, Jang A, Jo C, Park CS, Lee M (2007) Relationship between the concentration of biogenic amines and volatile basic nitrogen in fresh beef, pork, and chicken meat. Asian–Australasian Journal of Animal Sciences 20, 1278–1284.
Relationship between the concentration of biogenic amines and volatile basic nitrogen in fresh beef, pork, and chicken meat.Crossref | GoogleScholarGoogle Scholar |

Min JS, Lee SO, Jang A, Lee M, Kim Y (2004) Production of biogenic amines by microflora inoculated in meats. Asian-Australasian Journal of Animal Sciences 17, 1472–1478.
Production of biogenic amines by microflora inoculated in meats.Crossref | GoogleScholarGoogle Scholar |

Molognoni L, Daguer H, de Sá Ploêncio LA, De Dea Lindner J (2018) A multi-purpose tool for food inspection: Simultaneous determination of various classes of preservatives and biogenic amines in meat and fish products by LC–MS. Talanta 178, 1053–1066.
A multi-purpose tool for food inspection: Simultaneous determination of various classes of preservatives and biogenic amines in meat and fish products by LC–MS.Crossref | GoogleScholarGoogle Scholar | 29136796PubMed |

Nishibori N, Fujihara S, Akatuki T (2007) Amounts of polyamines in foods in Japan and intake by Japanese. Food Chemistry 100, 491–497.
Amounts of polyamines in foods in Japan and intake by Japanese.Crossref | GoogleScholarGoogle Scholar |

Oliveira GE, Figueiredo TC, Souza MR, Oliveira AL, Cançado SV, Gloria MBA (2009) Bioactive amines and quality of egg from Dekalb hens under different storage conditions. Poultry Science 88, 2428–2434.
Bioactive amines and quality of egg from Dekalb hens under different storage conditions.Crossref | GoogleScholarGoogle Scholar | 19834096PubMed |

Paulsen P, Bauer F (2007) Spermine and spermidine concentrations in pork loin as affected by storage, curing and thermal processing. European Food Research and Technology 225, 921–924.
Spermine and spermidine concentrations in pork loin as affected by storage, curing and thermal processing.Crossref | GoogleScholarGoogle Scholar |

Prester L (2011) Biogenic amines in fish, fish products and shellfish: a review. Food Additives & Contaminants: Part A 28, 1547–1560.
Biogenic amines in fish, fish products and shellfish: a review.Crossref | GoogleScholarGoogle Scholar |

Qaisrani SN, Van Krimpen MM, Kwakkel RP, Verstegen MWA, Hendriks WH (2015) Dietary factors affecting hindgut protein fermentation in broilers: a review. Poultry Science 71, 139–160.
Dietary factors affecting hindgut protein fermentation in broilers: a review.Crossref | GoogleScholarGoogle Scholar |

Ramos B, Pinho O, Ferreira IMPLVO (2009) Changes of yolk biogenic amine concentrations during storage of shell hen eggs. Food Chemistry 116, 340–344.
Changes of yolk biogenic amine concentrations during storage of shell hen eggs.Crossref | GoogleScholarGoogle Scholar |

Ramos RM, Valente IM, Rodrigues JA (2014) Analysis of biogenic amines in wines by salting-out assisted liquid–liquid extraction and high-performance liquid chromatography with fluorimetric detection. Talanta 124, 146–151.
Analysis of biogenic amines in wines by salting-out assisted liquid–liquid extraction and high-performance liquid chromatography with fluorimetric detection.Crossref | GoogleScholarGoogle Scholar | 24767456PubMed |

Rêgo IOP, Menezes LDM, Figueiredo TC, Oliveira DD, Rocha JSR, Lara LJC, Lima AL, Souza MR, Cançado SV (2014) Bioactive amines and microbiological quality in pasteurized and refrigerated liquid whole egg. Poultry Science 93, 1018–1022.
Bioactive amines and microbiological quality in pasteurized and refrigerated liquid whole egg.Crossref | GoogleScholarGoogle Scholar |

Ruiz-Capillas C, Jiménez-Colmenero F (2004) Biogenic amines in meat and meat products. Critical Reviews in Food Science and Nutrition 44, 489–499.
Biogenic amines in meat and meat products.Crossref | GoogleScholarGoogle Scholar | 15969322PubMed |

Sander JE, Cai T, Dale N, Bennett LW (1996) Development of biogenic amines during fermentation of poultry carcasses. Journal of Applied Poultry Research 5, 161–166.
Development of biogenic amines during fermentation of poultry carcasses.Crossref | GoogleScholarGoogle Scholar |

Savvaidis I, Ruiz-Capillas C (2009) Biogenic amines in fresh and processed meat and meat products. ‘Biological Aspects of biogenic amines, polyamines, and conjugates’. (Ed. G Dandrifosse) pp. 231–266. (Transworld Research Network: Kerala, India)

Shalaby AR (1996) Significance of biogenic amines to food safety and human health. Food Research International 29, 675–690.
Significance of biogenic amines to food safety and human health.Crossref | GoogleScholarGoogle Scholar |

Silla Santos MH (1996) Biogenic amines: their importance in foods. International Journal of Food Microbiology 29, 213–231.
Biogenic amines: their importance in foods.Crossref | GoogleScholarGoogle Scholar | 8796424PubMed |

Silva CMG, Glória MBA (2002) Bioactive amines in chicken breast and thigh after slaughter and during storage at 4±1°C and in chicken-based meat products. Food Chemistry 78, 241–248.
Bioactive amines in chicken breast and thigh after slaughter and during storage at 4±1°C and in chicken-based meat products.Crossref | GoogleScholarGoogle Scholar |

Sirocchi V, Caprioli G, Cecchini C, Coman MM, Cresci A, Maggi F, Papa F, Ricciutelli M, Vittori S, Sagratini G (2013) Biogenic amines as freshness index of meat wrapped in a new active packaging system formulated with essential oils of Rosmarinus officinalis. International Journal of Food Sciences and Nutrition 64, 921–928.
Biogenic amines as freshness index of meat wrapped in a new active packaging system formulated with essential oils of Rosmarinus officinalis.Crossref | GoogleScholarGoogle Scholar | 23815565PubMed |

Smith TK (1990) Effect of dietary putrescine on whole body growth and polyamine metabolism. Proceedings of the Society for Experimental Biology and Medicine Society for Experimental Biology and Medicine 194, 332–336.

Smith TK, Mogridge J-AL, Sousadias MG (1996) Growth-promoting potential and toxicity of spermidine, a polyamine and biogenic amine found in foods and feedstuffs. Journal of Agricultural and Food Chemistry 44, 518–521.
Growth-promoting potential and toxicity of spermidine, a polyamine and biogenic amine found in foods and feedstuffs.Crossref | GoogleScholarGoogle Scholar |

Smith TK, Tapia-Salazar M, Cruz-Suarez LE, Ricque-Marie D (2000) Feed-borne biogenic amines: natural toxicants or growth promotors? In ‘Avances en Nutrición Acuícola V. Memorias del V Simposium Internacional de Nutrición Acuícola’, Mérida, Yucatán, Mexico. (Eds LE Cruz-Suarez, D Ricque-Marie, M Tapia-Salazar, MA Olvera-Novoa, R Civera-Cerecedo) pp. 24–32. (Universidad Autónoma de Nuevo León: Monterrey, NL, México)

Sousadias MG, Smith TK (1995) Toxicity and growth-promoting potential of spermine when fed to chicks. Journal of Animal Science 73, 2375–2381.
Toxicity and growth-promoting potential of spermine when fed to chicks.Crossref | GoogleScholarGoogle Scholar | 8567475PubMed |

Takemoto E, Evangelista WP, Minazzi-Rodrigues RS, Marsiglia DAP, Oliveira CAF, Glória MBA (2014) Surto de intoxicação por histamina associado ao consumo de atum em conserva no Estado de São Paulo, Brasil. BEPA 11, 25–28.

Tamim NM, Doerr JA (2003) Effect of putrefaction of poultry carcasses prior to rendering on biogenic amine production. Journal of Applied Poultry Research 12, 456–460.
Effect of putrefaction of poultry carcasses prior to rendering on biogenic amine production.Crossref | GoogleScholarGoogle Scholar |

ten Brink B, Damink C, Joosten HMLJ, Huis in’t Veld JHJ (1990) Occurrence and formation of biologically active amines in foods. International Journal of Food Microbiology 11, 73–84.
Occurrence and formation of biologically active amines in foods.Crossref | GoogleScholarGoogle Scholar | 2223522PubMed |

Veciana-Nogués MT, Mariné-Font A, Vidal-Carou MC (1997) Biogenic amines as hygienic quality indicators of tuna. Relationships with microbial counts, ATP-related compounds, volatile amines and organoleptic changes. Journal of Agricultural and Food Chemistry 45, 2036–2041.
Biogenic amines as hygienic quality indicators of tuna. Relationships with microbial counts, ATP-related compounds, volatile amines and organoleptic changes.Crossref | GoogleScholarGoogle Scholar |

Vidal-Carou MC, Izquierdo-Pulido ML, Martín-Morro MC, Mariné-Font A (1990) Histamine and tyramine in meat products: relationship with meat spoilage. Food Chemistry 37, 239–249.
Histamine and tyramine in meat products: relationship with meat spoilage.Crossref | GoogleScholarGoogle Scholar |

Vinci G, Antonelli ML (2002) Biogenic amines: quality index of freshness in red and white meat. Food Control 13, 519–524.
Biogenic amines: quality index of freshness in red and white meat.Crossref | GoogleScholarGoogle Scholar |

Visciano P, Schirone M, Tofalo R, Suzzi G (2012) Biogenic amines in raw and processed seafood. Frontiers in Microbiology 3, 1–10.
Biogenic amines in raw and processed seafood.Crossref | GoogleScholarGoogle Scholar |

World Renderers Organization (WRO) (2013) ‘Guidelines for hygienic rendering.’ (Ed. Intergovernmental Panel on Climate Change) pp. 1–11. (Cambridge University Press: Cambridge, UK)

Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW (2012) ‘Diseases of swine.’ 10th edn. (Eds JJ Zimmerman, LA Karriker, A Ramirez, KJ Schwartz, GW Stevenson) (Wiley-Blackwell: Ames, IA)