Different Acute Effects of the Tyrosine Hydroxylase Inhibitors a-Methyl-p-Tyrosine and 3-Iodo-L-Tyrosine on Hypothalamic Noradrenaline Activity and Adrenocorticotrophin Release in the Rat

Abstract

Computerized gas chromatography-mass spectrometry techniques using selected ion monitoring and deuterated internal standards were used to assay simultaneously the medial basal hypothalamic concentrations of dopamine (DA) and noradrenaline (NA) and their major metabolites in individual rats 30 min after the administration of two different inhibitors of tyrosine hydroxylase, a-methyl-ptyrosine (a-MT) and 3-iodo-L-tyrosine (MIT). Consistent with inhibition of DA synthesis, administration of both a-MT and MIT resulted in marked reductions (P

https://doi.org/10.1071/BI9830519

© CSIRO 1983