Repeated multimodal supervision programs to reduce the central line-associated bloodstream infection rates in an Indian corporate hospital
Namita Jaggi A B and Pushpa Sissodia AA Artemis Health Institute, Sector 51, Gurgaon, Haryana 122001, India.
B Corresponding author. Email: namita@artemishealthsciences.com
Healthcare Infection 19(2) 53-58 https://doi.org/10.1071/HI13030
Submitted: 2 July 2012 Accepted: 16 October 2013 Published: 19 December 2013
Abstract
Background: Central line-associated bloodstream infections (CLABSI) are associated with significant morbidity, mortality and costs. Multimodal intervention programs are effective in bringing down the rates of CLABSI, but they are difficult to sustain. In an attempt to improve sustainability, we implemented two multimodal intervention programs focusing on high-yield measures and assessed their effect on monthly CLABSI rates over a period of 42 months.
Methods: The CLABSI rates were tracked on a monthly basis in a 300-bed Indian Corporate hospital and an analysis of the various contributing variables was done. The first intervention program in July 2009 put into practice the central line bundle. The second program went beyond the bundle and introduced high-yield measures like dedicated central line team and trolley, involved the senior management and promoted the ‘Scrub the Hub’ campaign while rectifying deficiencies observed in the first intervention program. The rates of CLABSI were statistically analysed in both the pre- and post-intervention periods.
Results: The CLABSI rates varied between 0 to 9.8 infections per 1000 catheter days in the 42 months period, the mean being 2.9. The difference in mean CLABSI rates before and after the first intervention program was not significant (5.2 versus 4.4 infections per 1000 catheter days (P > 0.05)). However, the next intervention program saw a significant decrease in the mean rates of CLABSI in the subsequent 24 months (0.7 infections per 1000 catheter days (P < 0.05)). An overall 86.3% reduction in CLABSI rates in the entire study period was observed.
Conclusions: Repeated multimodal intervention programs with a focus on high-yield measures resulted in a sustained reduction in CLABSI rates (86.3%).
References
[1] Rello J, Ochagavia A, Sabanes E, Roque M, Mariscal D, Reynaga E, et al Evaluation of outcome of intravenous catheter-related infections in critically ill patients. Am J Respir Crit Care Med 2000; 162 1027–30.| Evaluation of outcome of intravenous catheter-related infections in critically ill patients.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3cvotFajsQ%3D%3D&md5=bf4b3a470c170cd24c3b319bac17088bCAS | 10988125PubMed |
[2] Mermel LA. Prevention of intravascular catheter-related infections. Ann Intern Med 2000; 132 391–402. [Erratum, Ann Intern Med 2000;133 : 5.]
| Prevention of intravascular catheter-related infections.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3c7ktlSlsA%3D%3D&md5=9459145940b50d1637f7825e79317e04CAS | 10691590PubMed |
[3] Dudeck MA, Horan TC, Peterson KD, Bridson KA, Morrell GC, Pollock DA, et al. National Healthcare Safety Network (NHSN) Report, Data Summary for 2009. Device-associated Module. Atlanta, GA: Centers for Disease Control and Prevention; 2010.
[4] Edwards JR, Peterson KD, Andrus ML,, Tolson J, Goulding J, Dudeck M, et al National Healthcare Safety Network (NHSN) Report, Data Summary for 2006, issued June 2007. Am J Infect Control 2007; 35 290–301.
| National Healthcare Safety Network (NHSN) Report, Data Summary for 2006, issued June 2007.Crossref | GoogleScholarGoogle Scholar | 17577475PubMed |
[5] Rosenthal VD. Central Line-Associated Bloodstream Infections in Limited resource Countries: A Review of Literature. Clin Infect Dis 2009; 49 1899–907.
| Central Line-Associated Bloodstream Infections in Limited resource Countries: A Review of Literature.Crossref | GoogleScholarGoogle Scholar | 19911941PubMed |
[6] CDC Guidelines for the prevention of intravascular catheter-related infections. Morb Mortal Wkly Rep 2002; 51 1–29.
[7] CDC Vital Signs: Central Line-Associated Blood Stream Infections — United States, 2001, 2008, and 2009. Morb Mortal Wkly Rep 2011; 60 1–60.
[8] Sheth NK, Franson TR, Rose HD, Buckmire FL, Cooper JA, Sohnle PG. Colonization of bacteria on polyvinyl chloride and Teflon intravascular catheters in hospitalized patients. J Clin Microbiol 1983; 18 1061–3.
| 1:STN:280:DyaL2c%2Fmt1Wqtw%3D%3D&md5=ecf6c21b800f2e21b19be12a6e6457e2CAS | 6643657PubMed |
[9] Herrmann M, Lai QJ, Albrecht RM, Mosher DF, Proctor RA. Adhesion of Staphylococcus aureus to surface-bound platelets: role of fibrinogen/fibrin and platelet integrins. J Infect Dis 1993; 167 312–22.
| Adhesion of Staphylococcus aureus to surface-bound platelets: role of fibrinogen/fibrin and platelet integrins.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3s7jt1ersg%3D%3D&md5=92ec3295d5bc5399aeb01a986889a163CAS | 8421166PubMed |
[10] Gray ED, Peters G, Verstegen M, Regelmann WE. Effect of extracellular slime substance from Staphylococcus epidermidis on the human cellular immune response. Lancet 1984; 323 365–7.
| Effect of extracellular slime substance from Staphylococcus epidermidis on the human cellular immune response.Crossref | GoogleScholarGoogle Scholar |
[11] Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, et al An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU. N Engl J Med 2006; 355 2725–32.
| An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhslSmtA%3D%3D&md5=537496f03dac4abb5fd133551e49b1afCAS | 17192537PubMed |
[12] O’Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, et al. Guidelines for the Prevention of Intravascular Catheter-Related Infections. Atlanta, GA: Centers for Disease Control and Prevention; 2011.
[13] Tan CC, Zanariah Y, Lim KI, Balan S. Central Venous Catheter-Related Blood Stream Infections: Incidence and an Analysis of Risk Factors. Med J Malaysia 2007; 62 370–4.
| 1:STN:280:DC%2BD1critlSjug%3D%3D&md5=fa098345aa2c42960e36804751ca01d4CAS | 18705468PubMed |
[14] Zingg W, Imhof A, Maggiorini M, Stocker R, Keller E, Ruef C, et al Impact of a prevention strategy targeting hand hygiene and catheter care on the incidence of catheter-related bloodstream infections. Crit Care Med 2009; 37 2167–73.
| Impact of a prevention strategy targeting hand hygiene and catheter care on the incidence of catheter-related bloodstream infections.Crossref | GoogleScholarGoogle Scholar | 19487942PubMed |
[15] Marschall J, Mermel LA, Classen D,, Arias K, Podgorny K, Anderson D, et al Strategies to prevent central line-associated bloodstream infections in acute care hospitals. Infect Control Hosp Epidemiol 2008; 29 S22–30.
| Strategies to prevent central line-associated bloodstream infections in acute care hospitals.Crossref | GoogleScholarGoogle Scholar | 18840085PubMed |
[16] CDC National Health and Safety Network (NHSN) System report, data summary from October 1986–April 1998, issued June 1998. Am J Infect Control 1998; 26 522–33.
| National Health and Safety Network (NHSN) System report, data summary from October 1986–April 1998, issued June 1998.Crossref | GoogleScholarGoogle Scholar | 9795682PubMed |
[17] CDC National Health and Safety Network (NHSN) System report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32 470–85.
| National Health and Safety Network (NHSN) System report, data summary from January 1992 through June 2004, issued October 2004.Crossref | GoogleScholarGoogle Scholar | 15573054PubMed |
[18] Burrell AR, McLaws M, Murgo M, Calabria E, Pantle AC, Herkes R. Aseptic insertion of central venous lines to reduce bacteraemia The Central Line Associated Bacteraemia in NSW Intensive Care Units (CLAB ICU) Collaborative. Med J Aust 2011; 194 583–7.
| 21644871PubMed |
[19] Bouza E, Munoz P, Lopez-Rodriguez J,, Perez M, Rincon C, Rabadan P, et al A needleless closed system device (CLAVE) protects from intravascular catheter tip and hub colonization: a prospective randomized study. J Hosp Infect 2003; 54 279–87.
| A needleless closed system device (CLAVE) protects from intravascular catheter tip and hub colonization: a prospective randomized study.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3svislOgsA%3D%3D&md5=6d166c6fce010b94d371156a1819595eCAS | 12919758PubMed |
[20] Rosenthal VD, Guzman S, Pezzotto SM, Crnich CJ. Effect of an infection control program using education and performance feedback on rates of intravascular device- associated bloodstream infections in intensive care units in Argentina. Am J Infect Control 2003; 31 405–9.
| Effect of an infection control program using education and performance feedback on rates of intravascular device- associated bloodstream infections in intensive care units in Argentina.Crossref | GoogleScholarGoogle Scholar | 14639436PubMed |
[21] CDC National Health and Safety Network (NHSN) System report, data summary from January 1990–May 1999, issued June 1999. Am J Infect Control 1999; 27 520–32.
| National Health and Safety Network (NHSN) System report, data summary from January 1990–May 1999, issued June 1999.Crossref | GoogleScholarGoogle Scholar | 10586157PubMed |
[22] Pfaller MA, Jones RN, Messer SA, Edmond MB, Wenzel RP. National surveillance of nosocomial blood stream infection due to Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program. Diagn Microbiol Infect Dis 1998; 31 327–32.
| National surveillance of nosocomial blood stream infection due to Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXjtFWgsb8%3D&md5=4ab15e484db75b5175f0f0574c64accbCAS | 9597393PubMed |
[23] Pfaller MA, Jones RN, Messer SA, Edmond MB, Wenzel RP. National surveillance of nosocomial blood stream infection due to species of Candida other than Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program. Diagn Microbiol Infect Dis 1998; 30 121–9.
| National surveillance of nosocomial blood stream infection due to species of Candida other than Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1c3hsVOqug%3D%3D&md5=1f389c0a26c35eb737288d20497e1193CAS | 9554180PubMed |