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Comparisons of Vaginal Flora Patterns among Sexual Behavior Groups of Women – Implications for the Pathogenesis of Bacterial Vaginosis

Kristin Olson , Louis Boohaker , Jane Schwebke , Stella Aslibekyan , Christina Muzny

Abstract

ABSTRACT Background: Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women. The primary objective of this study was to compare the prevalence of BV by Nugent score among African-American women who have sex with women (WSW) and women who have sex with women and men (WSWM) compared to an age-matched group of women who have sex with men (WSM). Secondary objectives were to correlate low (7-8) vs. high (9-10) Nugent scores with vaginal symptoms among women with BV and to correlate BV diagnosis with sexual practices. Methods: We performed a secondary analysis of clinical and laboratory data from African-American WSW (n=73) and WSWM (n=68) participating in the Women’s Sexual Health Project (August 2011-October 2013) and a 3:1 age-matched group of African-American WSM participating in the Longitudinal Study of Vaginal Flora (August 1999-February 2002) at an STI clinic (n=423). Results: Compared to WSM, WSW and WSWM were significantly more likely to have BV based on Nugent score (OR 2.63; 95% CI 1.55-4.48; P <0.01) and (OR 3.67; 95% CI 2.17-6.21; P <0.01), respectively. WSW and WSWM with BV were not significantly more likely to have higher Nugent scores (9-10) than WSM with BV. Among women with BV reporting symptoms, there was no significant difference in the proportion of women with low-positive (7-8) versus high-positive (9-10) Nugent scores. Women who participated in receptive vaginal sex (penile or digital) within the 30 days preceding study enrollment were significantly more likely to have BV by Nugent score (OR 2.50; 95% CI 1.57-3.63; P<0.01). Conclusion: WSW and WSWM were significantly more likely to have BV than WSM. Further analysis of sexual practices data among sexual behavior groups of women is needed to determine their potential impact on rates of BV.

SH17087  Accepted 28 July 2017

© CSIRO 2017