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Characterisation of locoweeds and their effect on livestock production in the western rangelands of China: a review

Hao Lu A , Dan Dan Cao A , Feng Ma A , Shan Shan Wang A , Xiao Wen Yang A , Wen Long Wang A , Qi Wu Zhou A and Bao Yu Zhao A B
+ Author Affiliations
- Author Affiliations

A College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100 PR China.

B Corresponding author. Email: zhaobaoyu12005@163.com

The Rangeland Journal 36(2) 121-131 https://doi.org/10.1071/RJ13105
Submitted: 29 May 2013  Accepted: 16 December 2013   Published: 20 January 2014

Abstract

The rangelands of China are an important resource for livestock production, and play a strategic role in maintaining ecosystems and protecting the living environment of humans. Drought, overgrazing, infrastructure development, insufficient investment and poor management of rangelands have led to the invasion and spread of poisonous weeds in these rangelands in recent years. The rapid spread of poisonous weeds over the last few decades have caused a series of ecological problems, including a decrease in biological diversity and consequent desertification, and they are seriously affecting the ecological balance of rangelands, and the sustainable livestock production. Locoweeds, which belong to the genera Oxytropis and Astragalus, are an important species of poisonous legumes in the western rangelands of China, causing large economic losses. This review summarises the species and their ecological distribution, the toxic ingredients, the poisoning mechanism of locoweeds and damage control techniques for locoweeds. It attempts to highlight certain issues relating to research on locoweeds and how they are being tackled in order to understand the significance of locoweeds in preserving ecosystem diversity and the steps that require to be taken to control the spread of locoweeds in the western natural rangeland of China.

Additional keywords: biological diversity, damage control techniques, desertification, poisonous weeds, toxins.


References

A, H. L., Dang, G. S., Li, C., Ni, Q. Y., and Lu, Y. B. (1996). Investigation of Oxytropis yellow rust virus in a meadow. Qinghai Prataculturae 5, 41–42.

Bao, R. Y., Lu, P., He, S., and Qian, Y. G. (2012). Extraction and determination of swainsonine from Oxytropis glabra populations in Hangjin banner. Journal of Inner Mongolia Forestry Science and Technology 38, 30–34.

Baucom, D. L., Romero, M., Belfon, R., and Creamer, R. (2012). Two new species of Undifilum, fungal endophytes of Astragalus (locoweeds) in the United States. Botany 90, 866–875.
Two new species of Undifilum, fungal endophytes of Astragalus (locoweeds) in the United States.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xht1Glu7fO&md5=857336633cef42198857c648e9241289CAS |

Braun, K. (1999). Fungal endophyte infection and swainsonine toxicity in locoweed. MSc Dissertation, New Mexico State University, NM, USA.

Braun, K., Romero, J., Liddell, C., and Creamer, R. (2003). Production of swainsonine by fungal endophytes of locoweed. Mycological Research 107, 980–988.
Production of swainsonine by fungal endophytes of locoweed.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXms12ntb0%3D&md5=983f08b9ade1311f37af0fb59d38d7f5CAS | 14531620PubMed |

Burrows, G. E., and Tyrl, R. J. (2001). ‘Toxic Plants of North America.’ (Iowa State University Press: Ames, IA.)

Cao, G. R., Zhang, S. X., and Zhang, Q. Y. (1986). Locoism of sheep in Yulin of Shaanxi and Haiyuan of Ningxia. Journal of Animal Toxicology 1, 18–21.

Cao, G. R., Li, S. J., Duan, D. X., Liu, N. L., Ma, S. M., Dang, J. H., Zhou, Z. M., Chen, Y. Z., Wang, D. G., Hei, Z. X., and Shi, C. J. (1988). Analysis of the toxic ingredients in Oxytropis ochrocephala. Veterinary Science in China 3, 41–43.

Cao, G. R., Li, S. J., Duan, D. X., Zhao, X. W., and Russell, J. M. (1989). Isolation and identification of the toxic ingredients from Oxytropis ochrocephala. Journal of Northwest Science-Technology University Agriculture and Forestry (Natural Science Edition) 17, l–7.

Cao, G. R., Li, S. J., and Zhao, B. Y. (1990). Analysis of Indolizidine alkaloids from locoweed in China. Journal of Animal Toxicology 5, 12–13.

Chen, S. K., and Sa, R. (1992). Investigation of distribution and harm situation of poisonous plants in desert grassland of Alashan. Chinese Journal of Grasslands 3, 60–62.

Colegate, S. M., Dorling, P. R., and Huxtable, C. R. (1979). A spectroscopic investigation of swainsonine: an α-mannosidase inhibitor isolated from Swainsona canescens. Australian Journal of Chemistry 32, 2257–2264.
A spectroscopic investigation of swainsonine: an α-mannosidase inhibitor isolated from Swainsona canescens.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3cXnt1Ohsw%3D%3D&md5=11320b65271a0772e24865c056a44722CAS |

Colodel, E. M., Gardner, D. R., Zlotowski, P., and Driemeier, D. (2002). Identification of swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning. Veterinary and Human Toxicology 44, 177–178.
| 1:CAS:528:DC%2BD38XkvFemtLs%3D&md5=7460bbdd0f8ae78178bc81e4d6ef2006CAS | 12046976PubMed |

Cook, D., Ralphs, M. H., Welch, K. D., and Stegelmeier, B. (2009a). Locoweed poisoning in livestock. Rangelands 31, 16–21.
Locoweed poisoning in livestock.Crossref | GoogleScholarGoogle Scholar |

Cook, D., Gardner, D. R., Ralphs, M. H., Pfister, J. A., Welch, K. D., and Green, B. T. (2009b). Swainsoninine concentrations and endophyte amounts of Undifilum oxytropis in different plant parts of Oxytropis sericea. Journal of Chemical Ecology 35, 1272–1278.
Swainsoninine concentrations and endophyte amounts of Undifilum oxytropis in different plant parts of Oxytropis sericea.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsVCqsbvO&md5=3bf2b995771304e0182e1ea5b4a4e5b5CAS | 19904570PubMed |

Cook, D., Gardner, D. R., Grum, D., Pfister, J. A., Ralphs, M. H., Welch, K. D., and Green, B. T. (2011). Swainsonine and endophyte relationships in Astragalus mollissimus and Astragalus lentiginosus. Journal of Agricultural and Food Chemistry 59, 1281–1287.
Swainsonine and endophyte relationships in Astragalus mollissimus and Astragalus lentiginosus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXivFelsg%3D%3D&md5=3f5be0aae338cd5154f69f6a6ab1918aCAS | 21214242PubMed |

Couch, J. F. (1926). Relative toxicity of lupine alkaloids. Australian Journal of Agricultural Research 32, 51–67.
| 1:CAS:528:DyaB28XhsFWhsw%3D%3D&md5=fe1595ba1d8030dbe82ab1f94a8844b6CAS |

Crawford, A. C. (1908). ‘Barium, A Cause of the Locoweed Disease.’ USDA, Bureau of Plant Industry Bulletin 129. (USDA: Washington, DC.)

Creamer, R., and Baucom, D. (2013). Fungal endophytes of locoweeds: a commensal relationship? Journal of Plant Physiology and Pathology 1, 1–4.

Cui, Z. H., Zhao, X. H., Li, Q. F., Wang, J. H., and Geng, G. X. (2008). Determination of swainsonine in Astragalus locoweed by internal standard gas chromatography. Journal of Northwest Science-Technology University Agriculture and Forestry (Natural Science Edition) 36, 17–21.
| 1:CAS:528:DC%2BD1MXhtVams7fO&md5=2c3fb370f909928d81801efb886cead7CAS |

Dantas, A. F. M., Riet-Correa, F., Gardner, D. R., Medeiros, R. M. T., Barros, S. S., Anjos, B. L., and Lucena, R. B. (2007). Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in North-eastern Brazil. Toxicon 49, 111–116.
Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in North-eastern Brazil.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtlWqurzO&md5=7910b959aaae4cf1f5f8153f613268b3CAS |

Davis, T. Z., Lee, S. T., Ralphs, M. H., and Panter, K. E. (2009). Selected common poisonous plants of the United States’ rangelands. Rangelands 31, 38–44.
Selected common poisonous plants of the United States’ rangelands.Crossref | GoogleScholarGoogle Scholar |

Ding, B. L., Wang, J. C., Xue, D. M., Jia, W. Z., and Wang, S. E. (1994). A study on the pathology of Oxytropis kansuensis intoxication on testes and epididymis of goats. Acta Veterinaire et Zootechnie Sinica 25, 368–374.

Dong, Y. F., Ding, Y. M., Yu, J., and Jin, Y. M. (1993). Quinolizidine alkaloids from Oxytropis ochrocephala Bunge. Journal of Plant Resources and Environment 2, 58–59.
| 1:CAS:528:DyaK3sXhs1Ghtrw%3D&md5=84b500908df32aa4000a4ae47d6ccbc8CAS |

Duan, Q. Y., Huang, X. Y., Li, C., Ni, J. M., and Di, D. L. (2010). Pretreatment of sample based on macroporous adsorptive resin and content determination of swainsonine in Oxytropis kansuensis Bunge by HPLC. Analysis and Testing Technology of Instruments 16, 6–10.
| 1:CAS:528:DC%2BC3cXpsFyhurc%3D&md5=9d054cb9979c57b42b68d9e829196a7dCAS |

Fan, Z. F., Fan, Y. Y., Zhao, B. Y., Wang, Y. C., and Tan, C. J. (2006). Progress in prevention of locoweed poisoning. Heilongjiang Animal Science and Veterinary Medicine 1, 24–25.

Fraps, G. S. (1936). ‘Locoine, the Poisonous Principle in Locoweed Astragalus earlei.’ (Texas Agriculture Experiment Station: Texas, TX.)

Gao, X. L., Cook, D., Ralphs, M. H., Yan, L., Gardner, D. R., Lee, S. T., Panter, K. E., Han, B., and Zhao, M. L. (2012). Detection of swainsonine and isolation of the endophyte Undifilum from the major locoweeds in Inner Mongolia. Biochemical Systematics and Ecology 45, 79–85.
Detection of swainsonine and isolation of the endophyte Undifilum from the major locoweeds in Inner Mongolia.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsFCks7%2FI&md5=4b49fc062e0c711a705228f0104aa1b1CAS |

Gardner, D. R., Molyneux, R. J., and Ralphs, M. H. (2001). Analysis of swainsonine: extraction methods, detection, and measurement in population of locoweeds (Oxytropis spp.). Journal of Agricultural and Food Chemistry 49, 4573–4580.
Analysis of swainsonine: extraction methods, detection, and measurement in population of locoweeds (Oxytropis spp.).Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXms1Ogu74%3D&md5=34eea300c392af218257ca235445b288CAS | 11599990PubMed |

Ge, P. B., Zhao, B. Y., Tong, D. W., Qiao, S. Y., Guo, X., Cao, G. R., Zhang, Y. K., and Dong, Q. (2003). Extraction and fractionation and identification of swainsonine on structure from Oxytropis glabra. Chinese Agricultural Science Bulletin 19, 1–4.

Grum, D. S., Cook, D., Gardner, D. R., Roper, J. M., Pfister, J. A., and Ralphs, M. H. (2012). Influence of seed endophyte amounts on swainsonine concentrations in Astragalus and Oxytropis locoweeds. Journal of Agricultural and Food Chemistry 60, 8083–8089.
Influence of seed endophyte amounts on swainsonine concentrations in Astragalus and Oxytropis locoweeds.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtFWhtr%2FN&md5=30b39f43f64c07b915392abb8cc685dcCAS | 22844873PubMed |

Huang, Y. D., Xiao, G. Z., Meng, J. C., and Kong, F. G. (1992). Isolation and analysis of toxic ingredients from Astragalus variabilis Bunge. Journal of Traditional Chinese Veterinary Medicine 4, 3–6.

Huang, Y. Q., Zhang, E. R., and Pan, W. F. (2003). Current status of locoweed toxocity. Shandong Science 16, 34–39.

James, L. F., and Panter, K. E. (1989). Locoweed poisoning in livestock. In: ‘Swainsonine and Related Glycosidase Inhibitors’. (Eds L. F. James, A. D. Elbein, R. J. Molyneux and C. D. Warren.) pp. 23–38. (Iowa State University Press: Ames, IA.)

James, L. F., Shupe, J. L., Binns, W., and Keeler, R. F. (1967). Abortive and teratogenic effects of locoweed on sheep and cattle. American Journal of Veterinary Research 28, 1379–1388.
| 1:STN:280:DyaF1c%2Fht1Gisw%3D%3D&md5=d0ae8020156b1ac17f9b39c9cad6bfd3CAS | 6069571PubMed |

Karasuno, T., Kanayama, Y., Nishiura, T., Nakao, H., Yonezawa, T., and Tarui, S. (1992). Glycosidase inhibitors (castanospermine and swainsonine) and neuraminidase inhibit pokeweed mitogen-induced B cell maturation. European Journal of Immunology 22, 2003–2008.
Glycosidase inhibitors (castanospermine and swainsonine) and neuraminidase inhibit pokeweed mitogen-induced B cell maturation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK38Xlt12rs7k%3D&md5=63ad0f405d9dcf2e255a5774febee448CAS | 1639102PubMed |

Lei, Q., and Bei, Z. L. (2009). Study on relationship between the poisonous plants in north-west ethnic regions and ethnoecology. Journal of Anhui Agricultural Sciences 37, 13979–13980.

Li, J. K. (1990). Research progress on livestock Oxytropis poisoning in China. Journal of Animal Toxicology 5, 17–20.

Li, J. K. (2000). Study on the ecological engineering control of harms of poisonous plants in Oxytropis sp. at pasture. Transactions of the Chinese Society of Agricultural Engineers 16, 99–102.

Li, Z. H., and Liu, P. C. (1978). Investigation of Achnatherum Inebrians (Oxytropis glabra) poisoning and its toxic ingredients analysis. Inner Mongolia Animal and Veterinary Medicine 1, 1–17.

Li, Y. Z., and Nan, Z. B. (2009). Symptomology and etiology of a new disease, yellow stunt, and root rot of standing milkvetch caused by Embellisia sp. in Northern China. Mycopathologia 163, 327–334.

Li, J. R., Liu, B. Q., Gao, X. Y., and Xu, L. H. (1980). Livestock poisoning investigation and diagnosis of Oxytropis glabra. Xinjiang Agricultural Sciences 4, 37–38.

Li, J. K., Yang, J. T., Pan, H. P., and Tang, Z. X. (1987). Investigation on livestock poisoning of Oxytropis kansuensis Bunge and Oxytropis ochrocephala Bunge. Veterinary Science in China 5, 22–23.

Li, J. K., Yang, J. T., and Tang, Z. X. (1988). A study on chemical control methods for Oxytropis ochrocephala. Chinese Journal of Grasslands 3, 8–11.

Li, Q. F., Wang, J. H., Li, R., Chen, Y., and Liu, Z. B. (2005). Detection of alkaloid and isolation of swainsonine from Oxytropis glacialis. Acta Veterinaire et Zootechnie Sinica 36, 1339–1343.

Li, Y. Z., Nan, Z. B., and Hou, F. J. (2007). The roles of an Embellisia sp. causing yellow stunt and root rot of Astragalus adsurgens and other fungi in the decline of legume pastures in northern China. Australasian Plant Pathology 36, 397–402.
The roles of an Embellisia sp. causing yellow stunt and root rot of Astragalus adsurgens and other fungi in the decline of legume pastures in northern China.Crossref | GoogleScholarGoogle Scholar |

Liu, Z. P. (2006). ‘Toxicosis of Animals.’ (China Agriculture Press: Beijing.)

Lu, X. K. (1986). Livestock Oxytropis and Astragalus strictus poisoning. Journal of Animal Toxicology 1, 32–33.

Lu, P. (2007). ‘Studies on Correlated Factors to Swainsonine in Three Oxytropis Species in Inner Mongolia.’ (Inner Mongolia Agricultural University: Hohhot, China.)

Lu, X. K., and Wang, J. (1982). Investigation of livestock toxic milk vetch poisoning in Nedong of Tibet. Veterinary Science in China 5, 27–29.

Lu, W., Song, Y. Y., Pong, L., Zhao, B. Y., Lu, H., Rong, J., Ma, Y., Li, R., and Wang, Z. X. (2011). Investigation and control measures on toxic plant disasters on grassland in Alax of Inner Mongolia. Progress in Veterinary Medicine 32, 71–75.
| 1:CAS:528:DC%2BC3MXmtlWmsr0%3D&md5=34f61384b41aa137e6f61c902cd6de1bCAS |

Lu, H., Wang, S. S., Zhou, Q. W., Zhao, Y. N., and Zhao, B. Y. (2012). Damage and control of major poisonous plants in the western grasslands of China. The Rangeland Journal 34, 329–339.
Damage and control of major poisonous plants in the western grasslands of China.Crossref | GoogleScholarGoogle Scholar |

Ma, S. J. (2008). The poisonous and harmfulness plant resource in grassland and its economy value in Haixi of Qinghai Province. Pratacultural Science 25, 98–103.

Ma, Z. H., Zhao, Z. M., and Ren, Q. F. (1994). Two new diseases of yellow hair grazyweed (Oxytropis ochrocephala BGE.). Journal of Ningxia Agricultural College 3, 30–32.

Ma, S. J., Li, H. Y., Wang, K., Mo, C. H., Zhao, B. Y., and Cao, G. R. (2000). A preventive experiment of Oxytropis poisoning in flocks of grazing sheep by use of ecosystem control project. Progress in Veterinary Medicine 21, 49–51.

Marsh, C. D. (1909). The locoweed disease of the Plains. USDA, Bureau of Animal Industry Bulletin 112, 15–34.

Marsh, C. D., Clawson, A. B., and Eggleston, W. W. (1919). The locoweed disease. US Department of Agriculture Bulletin 1054, 1–31.

Mathews, F. P. (1932). Locoism in domestic animals. Texas Agriculture Experimental Station Bulletin No. 456, Texas.

McDaniel, K. C., Sterling, T., Ivey, S. (2007). Herbicidal control of locoweed. In: ‘Poisonous Plants: Global Research and Solutions’. (Eds K. E. Panter, T. L. Wierenga and J. A. Pfister.) pp. 353–358. (CABI: Wallingford, UK.)

McLain-Romero, J., Creamer, R., Zepeda, H., Strickland, J., and Bell, G. (2004). The toxicosis of Embellisia fungi from locoweed (Oxytropis lambertii) is similar to locoweed toxicosis in rats. Journal of Animal Science 82, 2169–2174.
| 1:CAS:528:DC%2BD2cXlsFWksb8%3D&md5=8eed68b37b2bbc9fe50ebb5d96d6deb7CAS | 15309966PubMed |

Meng, X. Z., Hu, X. Q., Zhang, R. M., and You, Z. T. (1994). Study on toxic components in O. ochrocephala and O. glabra in Ningxia – Part 1. Toxic alkaloid analysis. Ningxia Journal of Agriculture Forestry Science and Technology 2, 37–40.

Mezher, H. A., Hough, L., and Richardson, A. (1984). A chiral synthesis of swainsonine from D-Glucose. Journal of the Chemical Society–Chemical Communications , 447–448.
| 1:CAS:528:DyaL2cXltlSqt74%3D&md5=11f51d8d21e922f6fe0f2a4c72449167CAS |

Ministry of Agriculture of PRC (1996). ‘The Grassland Resources of China.’ Animal Husbandry and Veterinary Department, National Animal Husbandry and Veterinary Station. (China Science and Technology Press: Beijing.)

Molyneux, R. J., and James, L. F. (1982). Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus). Science 216, 190–191.
Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus).Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL38XhvFCrsbs%3D&md5=85160a3a9d01974c66db01b28479611bCAS | 6801763PubMed |

Mukherjee, S., Dawe, A. L., and Creamer, R. (2012). Potential role for saccharopine reductase in swainsonine metabolism in endophytic fungus, Undifilum oxytropis. Fungal Biology 116, 902–909.
Potential role for saccharopine reductase in swainsonine metabolism in endophytic fungus, Undifilum oxytropis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtV2it7jM&md5=99c649c8ffa19a2ab70f50c2c9446761CAS | 22862918PubMed |

Obeidat, B. S., Strickland, J. R., Vogt, M. L., Loest, C. A., Sawyer, J. E., Reed, M. M., Krehbiel, C. R., Taylor, J. B., Halalsheh, R. A., and Chen, L. (2004). Effects of locoweed on serum constituents and rumen profiles of sheep. Journal of Animal Science 55, 410–414.

Oldrup, E., McLain-Romero, J., Padilla, A., Moya, A., Gardner, D., and Creamer, R. (2010). Localization of endophytic Undifilum fungi in locoweed seed and influence of environmental parameters on a locoweed in vitro culture system. Botany 88, 512–521.
Localization of endophytic Undifilum fungi in locoweed seed and influence of environmental parameters on a locoweed in vitro culture system.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXlvVWqu7g%3D&md5=099e6042757e40235d32c9e25b9babe6CAS |

Patrick, M., Adlard, M. W., and Keshavarz, T. (1993). Production of an indolizidine alkaloid, swainsonine by the filamentous fungus, Metarhizium anisopliae. Biotechnology Letters 15, 997–1000.
Production of an indolizidine alkaloid, swainsonine by the filamentous fungus, Metarhizium anisopliae.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXivFCjtg%3D%3D&md5=4104237688668e33ceadad66440bc67aCAS |

Pfister, A., and Stegelmeier, B. L. (2002). Conditioning taste aversions to locoweed (Oxytropis sericea) in horses. Journal of Animal Science 80, 79–83.
| 1:CAS:528:DC%2BD38XpsFWgsA%3D%3D&md5=3f9b0811b60026007c66d0d774e6c231CAS |

Pomerinke, M. A., Thompson, D. C., and Clason, D. L. (1995). Bionomics of Cleonidius trivittatus (Coleoptera: Curculionidae): native biological control of purple locoweed (Rosales: Fabaceae). Environmental Entomology 26, 1696–1702.

Pryor, B. M., Creamer, R., Shoemaker, R. A., McLain-Romero, J., and Hambleton, S. (2009). Undifilum, a new genus for endophytic Embellisia oxytropis and parasitic Helminthosporium bornmuelleri on legumes. Botany 87, 178–194.
Undifilum, a new genus for endophytic Embellisia oxytropis and parasitic Helminthosporium bornmuelleri on legumes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXjtlyntbo%3D&md5=d884e0783cb77d089165886640930b9fCAS |

Ralphs, M. H. (1992). Conditioned food aversion: training livestock to avoid eating poisonous plants. Journal of Range Management 45, 46–51.
Conditioned food aversion: training livestock to avoid eating poisonous plants.Crossref | GoogleScholarGoogle Scholar |

Ralphs, M. H., and Ueckert, D. N. (1988). Herbicide control of locoweeds: a review. Weed Technology 2, 460–465.
| 1:CAS:528:DyaL1MXlt1yhsw%3D%3D&md5=94ee3598959d12bdb6321a6bd4dd8bf3CAS |

Ralphs, M. H., Mickelsen, L. V., and Turner, D. L. (1987). Cattle grazing with locoweed: diet selection patterns of native and introduced cattle. Journal of Range Management 40, 333–335.
Cattle grazing with locoweed: diet selection patterns of native and introduced cattle.Crossref | GoogleScholarGoogle Scholar |

Ralphs, M. H., Mickelsen, L. V., Turner, D. L., and Nielsen, D. B. (1988). Control of white locoweed (Oxytropis sericea). Weed Science 36, 353–358.
| 1:CAS:528:DyaL1cXksFSiurk%3D&md5=91d171ca26b3631b55ffab6f22082400CAS |

Ralphs, M. H., Monaco, T. A., Valdez, J. R., and Graham, D. (2007). Seeding cool-season grasses to suppress white locoweed (Oxytropis sericea) reestablishment and increase forage production. Weed Technology 21, 661–669.
Seeding cool-season grasses to suppress white locoweed (Oxytropis sericea) reestablishment and increase forage production.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtleqs7zL&md5=43fefd41c3d81f3ef7a630738fd71394CAS |

Ralphs, M. H., Creamer, R., Baucom, D., Gardner, D. R., Welsh, S. L., Graham, J. D., Hart, C., Cook, D., and Stegelmeier, B. L. (2008). Relationship between the endophyte Embellisia spp. and the toxic alkaloid swainsonine in major locoweed species (Astragalus and Oxytropis). Journal of Chemical Ecology 34, 32–38.
Relationship between the endophyte Embellisia spp. and the toxic alkaloid swainsonine in major locoweed species (Astragalus and Oxytropis).Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXitVGqtLY%3D&md5=4a1fbe4982367886b1a8dc189d57eec3CAS | 18060459PubMed |

Ren, J. Z. (1954). Several poisonous weeds of grasslands of north-west China. Animal Husbandry and Veterinary Medicine 2, 56–60.

Reyna, R., Cooke, P., Grum, D., Cook, D., and Creamer, R. (2012). Detection and localization of the endophyte Undifilum oxytropis in locoweed tissues. Botany 90, 1229–1236.
Detection and localization of the endophyte Undifilum oxytropis in locoweed tissues.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xhs1Klsb%2FO&md5=4c969dc7adf3d01ce31e7fda51126f03CAS |

Rong, J., Lu, H., Zhao, B. Y., Wang, Z. X., Lu, W. M. Y., and Li, R. (2010). An overview of poisonous plants and their effects on animal husbandry in the United States. Scientia Agricultura Sinica 43, 3633–3644.

Schneider, M., Ungemach, F., Broquist, H., and Harris, T. (1983). (1S,2R,8R,8aR)-1,2,8- trihydroxyoctahydroindolizine (swainsonine), an a-mannosidase inhibitor from Rhizoctonia leguminicola. Tetrahedron 39, 29–32.
(1S,2R,8R,8aR)-1,2,8- trihydroxyoctahydroindolizine (swainsonine), an a-mannosidase inhibitor from Rhizoctonia leguminicola.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3sXhvFymsrc%3D&md5=864f8aeae84c26c1db5ea6918138e60bCAS |

Shao, S. X., Zheng, B. S., Zhao, C. Z., Yin, C. Q., Lang, Y. B., and Zhang, A. L. (2004). A study on selenium in Oxytropis and association of it with poisoning of livestock in Hexi corridor. Advances in Earth Sciences 19, 502–505.

Shen, M. H., Zhao, B. Y., Mo, C. H., Wang, K., Chang, J. J., and Tong, D. W. (2009). The investigation and prevention research of Oxytropis poisonous plants hazard in grassland of Qinghai. Heilongjiang Animal Science and Veterinary Medicine 342, 49–51.

Stegelmeier, B. L., Molyneux, R. J., Elbein, A. D., and James, L. F. (1995). The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine in rats. Veterinary Pathology 32, 289–298.
The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine in rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXmt1Gntbs%3D&md5=5d88f785d1f883ffa881c01e81c6c5e7CAS | 7604496PubMed |

Tan, Y. Y., Hong, Z. P., Guo, Q. H., Gao, J. X., Wang, J. H., and Li, Q. F. (1999). Preliminary studies on the extraction, separation and toxicities of alkaloids from Oxytropis glacialis Benth. ex Bunge collected in Tibet. Journal of Animal Toxicology 14, 22–26.

Tang, T., Li, Y. L., and Zhou, Q. P. (2007). The preliminary research on Oxytropis ochrocephala rust in alpine meadow around Qinghai lake. Pratacultural Science 24, 84–87.

Thompson, D. C., Knight, J. L., Sterling, T. M., and Murray, L. W. (1995). Preference for specific varieties of woolly locoweed by a specialist weevil Cleonidius trivittatus. Southwestern Entomology 3, 325–333.

Tong, D. W., Cao, G. R., and Li, S. J. (2001). Isolation and identification of swainsonine from O. kansuensis Bunge. Journal of Northwest Agriculture and Forestry University (Natural Science Edition) 3, 5–8.

Tulsiani, D. R., Broquist, H. P., James, L. F., and Touster, O. (1984). The similar effects of swainsonine and locoweed on tissue glycosidases and oligosaccharides of the pig indicate that the alkaloid is the principal toxin responsible for the induction of locoism. Archives of Biochemistry and Biophysics 232, 76–85.
The similar effects of swainsonine and locoweed on tissue glycosidases and oligosaccharides of the pig indicate that the alkaloid is the principal toxin responsible for the induction of locoism.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2cXltVGntbk%3D&md5=3280dede45b568a595048ad0cb052d20CAS | 6430242PubMed |

van den Elsen, J. M. H., Kuntz, D. A., and Rose, D. R. (2001). Structure of Golgi a-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. The EMBO Journal 20, 3008–3017.
Structure of Golgi a-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXltlaksLc%3D&md5=9705811c0b488b5a5c25d14832a3737aCAS |

Wang, J. L. (1993). ‘Annals of Epidemic Disease about Domestic Animal and Fowl of Qinghai Province.’ (Gansu Nationalities Publishing House: Gansu, China.)

Wang, J. H., Zhang, Z. H., Zhang, Q., and Gao, J. X. (1998). Report of livestock ‘Achnatherum Inebrians’ poisoning disease in Ali area of Tibet. Journal of Animal Toxicology 13, 22–27.

Wang, Y. C., Zhao, B. Y., Fan, Y. Y., Fan, Z. F., Tan, C. J., Dong, Q., and Cao, H. (2005). Isolation and identification of swainsonine in Oxytropis kansuensis. Proceedings of Veterinary Medicine 26, 91–93.

Wang, B. H., CiRen, D. J., Wang, J. L., Zhao, B. Y., Zha, L., and Xiu, H. (2009). Research progress of locoweed in Tibet. Grassland Turf 135, 81–86.

Wang, S., Chen, G. Y., Hu, J. J., and Ma, C. H. (2011). Determination of swainsonine content in Oxytrpis glabra DC in South Xinjiang by internal standard gas chromatography. Xinjiang Agricultural Sciences 48, 728–733.
| 1:CAS:528:DC%2BC3MXpt1SrtLk%3D&md5=370beedf7c3abfdf119ef99ebd4736d4CAS |

Xiao, Z. G. (1986). Livestock locoweed poisoning. Veterinary Science in China , 200–202.

Yang, X. P. (2002). Clinical symptoms of toxicosis in animals by grazyweed. Journal of Wuhan Institute of Science and Technology 15, 25–27.
| 1:CAS:528:DC%2BD38XnvVaqsb8%3D&md5=08b192fccfbaa8041715c34f35b9690cCAS |

Yang, G. Y., Yang, B. S., and Li, Z. H. (1989). Toxic ingredients and toxicity determination of Oxytropis glabra. Journal of Animal Toxicology 4, 8–10.

Yao, R. F. (2003). 90% of China’s natural grassland has different degrees of degradation. Pratacultural Science 20, 83.

Ye, S. J., Liu, J. L., and Huang, W. P. (2009). Progress in the synthesis of anticancer natural product swainsonine. Chinese Journal of Organic Chemistry 29, 689–695.
| 1:CAS:528:DC%2BD1MXosleksb0%3D&md5=5aff6de394005edbcaae59b3e3f8d8e8CAS |

Yu, R. M., Li, X., and Zhu, T. R. (1989). Structure determination of two new compounds from Oxytropis glabra. Journal of Shenyang Pharmaceutical University 6, 283.
| 1:CAS:528:DyaK3cXlsVyqsLs%3D&md5=8ae574213e517f88426506433a2751aeCAS |

Yu, Y. T., Wang, J. H., Wang, Y., Song, Y. M., Geng, G. X., and Li, Q. F. (2009). Identification of swainsonine-producing fungal endophytes from three species of locoweeds in Tibet. Scientia Agricultura Sinica 42, 3662–3671.
| 1:CAS:528:DC%2BD1MXhsVSnt7zO&md5=74f3855a644ab370de129e864b973381CAS |

Zhang, S. Q., and Yan, W. G. (2006). Problems of grassland ecosystems and their countermeasures in western China. Acta Prataculturae Sinica 15, 11–18.

Zhang, M. S., Gao, Q. D., Hou, D. H., Li, O., Chen, J. M., and Zhu, X. W. (1981). Oxytropis kansuonisis poisoning. Acta Veterinaire et Zootechnie Sinica 3, 145–149.

Zhao, B. Y. (2001). The systematic analysis and toxic comparative pathology research of locowed (Oxytropis Kansuensis) alkaloid composition. PhD Dissertation, Northwest A&F University, Yangling, China.

Zhao, X. H. (2008). Isolation and identification of swainsonine degrading bacteria and degradation character. MSc Dissertation, Northwest A&F University, Yangling, China.

Zhao, B. Y., and Cao, G. R. (2000). Progress in locoweed poisoning. Journal of Animal Toxicology 15, 19–22.

Zhao, B. Y., Cao, G. R., Duan, D. X., Li, S. J., Lu, X. K., and Wang, J. B. (1992). Studies on the goats toxicity of Astragalus strictus collected Tibet. Acta Veterinaire et Zootechnie Sinica 23, 276–280.

Zhao, B. Y., Tong, D. W., Ge, P. B., Dong, Q., and Mo, C. H. (2003). Locoweed harm investigation in the West grassland of China. Chinese Journal of Grasslands 25, 65–68.

Zhao, B. Y., Chen, S. S., Mo, C. H., Tong, D. W., Wang, K., and Cao, G. R. (2005). A study of extraction and its anti-tumor activity of swainsonine. Journal of Toxicology 19, 252.

Zhao, B. Y., Wang, J. J., Tan, C. J., Fan, Z. F., and Wang, Y. C. (2006). Isolation and identification of poisonous constituent swainsonine from Astragalus variabilis Bunge. Chinese Journal of Grasslands 28, 66–71.

Zhao, X. H., Cui, Z. H., Geng, G. X., Wang, J. H., Zhang, Z. M., Song, Y. M., and Liu, Z. B. (2007). Determination of swainsonine in Variation astragalus by the internal standard gas chromatography-methyl-α- D-mannosidase. Chinese Journal of Chromatography 25, 781–782.
| 1:CAS:528:DC%2BD2sXht1SisLrP&md5=0a81f9ef0be26bf011397c337b278897CAS |

Zhao, B. Y., Liu, Z. Y., Wan, X. P., Huo, X. H., Guo, X., Wang, J. J., Liu, Z. Y., Sun, L. S., and Shi, Z. C. (2008). Damage and control of poisonous-weeds in Chinese Western grassland. Scientia Agricultura Sinica 41, 3094–3103.

Zhao, B. Y., Wang, B. H., Mo, C. H., Dong, Q., Ge, L., Zha, L., Xiu, H., and Suo, D. (2011). The disaster survey of the Oxytropis glacial is poisoning in livestock in the Ngari of Tibet. Acta Agricultura Boreali-occidentalis Sinica 20, 40–46.

Zhou, S. Q., Huang, Z. J., and Ma, F. J. (2004). Comprehensive prevention and control methods for the main poisonous plants Oxytropis glabra in Inner Mongolia grassland. Inner Mongolia Science and Technology Economy 21, 49.

Zhou, Q. W., Bai, S., Lu, H., Zhao, B. Y., and Chen, J. P. (2012). Recent advances and issues on fungal endophyte of locoweed. Pratacultural Science 7, 1049–1057.