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REVIEW

A review of the epidemiology and surveillance of viral zoonotic encephalitis and the impact on human health in Australia

Beverley J. Paterson A E , John S. Mackenzie B C , David N. Durrheim A and David Smith D
+ Author Affiliations
- Author Affiliations

A School of Medicine and Public Health, Faculty of Health, The University of Newcastle

B Faculty of Health Sciences, Curtin University

C The Burnet Institute, Melbourne

D Division of Microbiology and Infectious Diseases, Western Australian Centre for Pathology and Medical Research

E Corresponding author. Email: beverley.paterson@hnehealth.nsw.gov.au

NSW Public Health Bulletin 22(6) 99-104 https://doi.org/10.1071/NB10076
Published: 25 July 2011

Abstract

Human encephalitis in Australia causes substantial mortality and morbidity, with frequent severe neurological sequelae and long-term cognitive impairment. This review discusses a number of highly pathogenic zoonotic viruses which have recently emerged in Australia, including Hendra virus and Australian bat lyssavirus which present with an encephalitic syndrome in humans. Encephalitis surveillance currently focuses on animals at sentinel sites and animal disease or definitive diagnosis of notifiable conditions that may present with encephalitis. This is inadequate for detecting newly emerged viral encephalatides. Hospital-based sentinel surveillance may aid in identifying increases in known pathogens or emergence of new pathogens that require a prompt public health response.


References

[1]  Huppatz C, Durrheim DN, Levi C, Dalton C, Williams D, Clements MS, et al. Etiology of encephalitis in Australia, 1990-2007. Emerg Infect Dis 2009; 15 1359–65.
Etiology of encephalitis in Australia, 1990-2007.Crossref | GoogleScholarGoogle Scholar |

[2]  Huppatz C, Kelly PM, Levi C, Dalton C, Williams D, Durrheim DN. Encephalitis in Australia, 1979–2006: trends and aetiologies. Commun Dis Intell 2009; 33 192–7.

[3]  Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases. Nature 2004; 430 242–9.
The challenge of emerging and re-emerging infectious diseases.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXlsVGjt7w%3D&md5=3035f93b7b8a30f70243a571bfb8b0c1CAS |

[4]  Morse SS. The public health threat of emerging viral disease. J Nutr 1997; 127 951S–7S.
| 1:CAS:528:DyaK2sXjtVCgur0%3D&md5=1e61940f18cc45e098232dc969c7f606CAS |

[5]  Organisation Mondiale de la Sante Animale. One world, one health 2009.

[6]  Jones KE, Patel NG, Levy MA, Storeygard A, Balk D, Gittleman JL, et al. Global trends in emerging infectious diseases. Nature 2008; 451 990–3.
Global trends in emerging infectious diseases.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXit1ygurg%3D&md5=b9f3fe281ca35c46242e3c5c2e8cfa9dCAS |

[7]  Australian Government Department of Health and Ageing. Arbovirus and malaria surveillance. Available from: http://www.health.gov.au/arbovirus (Cited 9 September 2010.)

[8]  Hess IMR, Massey PD, Walker B, Middleton DJ, Wright TM. Hendra virus: what do we know? N S W Public Health Bull 2011; 22 118–22.
Hendra virus: what do we know?Crossref | GoogleScholarGoogle Scholar |

[9]  Trevejo RT. Acute encephalitis hospitalizations, California, 1990–1999: unrecognized arboviral encephalitis? Emerg Infect Dis 2004; 10 1442–9.

[10]  Halstead SB, Jacobson J. Japanese encephalitis. Adv Virus Res 2003; 61 103–38.
Japanese encephalitis.Crossref | GoogleScholarGoogle Scholar |

[11]  Mackenzie JS, Williams DT, Smith DW. Japanese encephalitis virus: the geographic distribution, incidence, and spread of a virus with a propensity to emerge in new areas. In: Tabor E, editor. Emerging viruses in human populations. Amsterdam: Elsevier; 2007. pp. 201–68.

[12]  Burke DS, Leake CJ. Japanese encephalitis. In: Monarth TP, editor. The arboviruses: Epidemiology and Ecology. Boca Raton: CRC Press; 1988. pp. 63–92.

[13]  Vaughn DW, Hoke CH. The epidemiology of Japanese encephalitis: prospects for prevention. Epidemiol Rev 1992; 14 197–221.
| 1:STN:280:DyaK3s7ntVCgtQ%3D%3D&md5=d432e1dafb6f7fb1af49276ab86cdf52CAS |

[14]  Endy TP, Nisalak A. Japanese encephalitis virus: ecology and epidemiology. Curr Top Microbiol Immunol 2002; 267 11–48.
| 1:STN:280:DC%2BD38zktVOgtA%3D%3D&md5=32d253d16a076b1f85e0b295c03f937dCAS |

[15]  Mackenzie JS, Johansen CA, Ritchie SA, van den Hurk AF, Hall RA. Japanese encephalitis as an emerging virus: the emergence and spread of Japanese encephalitis virus in Australasia. Curr Top Microbiol Immunol 2002; 267 49–73.
| 1:STN:280:DC%2BD38zktVOmsg%3D%3D&md5=37e3da3bfe19ff8ec5abf4d6ced75e22CAS |

[16]  Peiris JS, Amerasinghe FP, Arunagiri CK, Perera LP, Karunaratne SH, Ratnayake CB, et al. Japanese encephalitis in Sri Lanka: comparison of vector and virus ecology in different agro-climatic areas. Trans R Soc Trop Med Hyg 1993; 87 541–8.
Japanese encephalitis in Sri Lanka: comparison of vector and virus ecology in different agro-climatic areas.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2c%2FptVOjtg%3D%3D&md5=c8f6d39d286a054a5a408a8a1c93fee7CAS |

[17]  National Health and Medical Research Council. The Australian Immunisation Handbook. 9th ed. 2008. Available from: http://www.health.gov.au/internet/immunise/publishing.nsf/Content/Handbook-japanese (Cited 14 September 2010.)

[18]  Mackenzie JS, Lindsay MD, Coelen RJ, Broom AK, Hall RA, Smith DW. Arboviruses causing human disease in the Australasian zoogeographic region. Arch Virol 1994; 136 447–67.
Arboviruses causing human disease in the Australasian zoogeographic region.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2czgsVentg%3D%3D&md5=2e9fa40897f4062f6cd5859c43606444CAS |

[19]  Broom AK, Lindsay MD, Plant AJ, Wright AE, Condon RJ, Mackenzie JS. Epizootic activity of Murray Valley encephalitis virus in an aboriginal community in the southeast Kimberley region of Western Australia: results of cross-sectional and longitudinal serologic studies. Am J Trop Med Hyg 2002; 67 319–23.

[20]  Cordova SP, Smith DW, Broom AK, Lindsay MD, Dowse GK, Beers MY. Murray Valley encephalitis in Western Australia in 2000, with evidence of southerly spread. Commun Dis Intell 2000; 24 368–72.
| 1:STN:280:DC%2BD3M7lslCksg%3D%3D&md5=ced27192fafa6468ae658da4af7b2e7cCAS |

[21]  Brown A, Bolisetty S, Whelan P, Smith D, Wheaton G. Reappearance of human cases due to Murray Valley encephalitis virus and Kunjin virus in central Australia after an absence of 26 years. Commun Dis Intell 2002; 26 39–44.

[22]  Evans IA, Hueston L, Doggett SL. Murray Valley encephalitis virus. N S W Public Health Bull 2009; 20 195–6.
Murray Valley encephalitis virus.Crossref | GoogleScholarGoogle Scholar |

[23]  Johansen CA, Susai V, Hall RA, Mackenzie JS, Clark DC, May FJ, et al. Genetic and phenotypic differences between isolates of Murray Valley encephalitis virus in Western Australia, 1972–2003. Virus Genes 2007; 35 147–54.
Genetic and phenotypic differences between isolates of Murray Valley encephalitis virus in Western Australia, 1972–2003.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXnvFeisbk%3D&md5=08cb1c4025ad92d69a829e2167b7a509CAS |

[24]  Mackenzie JS, Poidinger M, Lindsay MD, Hall RA, Sammels LM. Molecular epidemiology and evolution of mosquito-borne flaviviruses and alphaviruses enzootic in Australia. Virus Genes 1995; 11 225–37.
Molecular epidemiology and evolution of mosquito-borne flaviviruses and alphaviruses enzootic in Australia.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28Xkt1Wnsb0%3D&md5=7d977918c40933ed53c1e53ff287d631CAS |

[25]  Broom AK, Lindsay MD, Harrington SA, Smith DW. Investigation of the southern limits of Murray Valley encephalitis activity in Western Australia during the 2000 wet season. Vector Borne Zoonotic Dis 2002; 2 87–95.
Investigation of the southern limits of Murray Valley encephalitis activity in Western Australia during the 2000 wet season.Crossref | GoogleScholarGoogle Scholar |

[26]  Smith DW, Broom AK, Wallace MJ. Prevalence of antibody to Murray Valley encephalitis virus in Aboriginal communities in the Kimberley region of Western Australia in 1995. Arbovirus Research in Australia 1997; 7.

[27]  Spencer JD, Azoulas J, Broom AK, Buick TD, Currie B, Daniels PW, et al. Murray Valley encephalitis virus surveillance and control initiatives in Australia. National Arbovirus Advisory Committee of the Communicable Diseases Network Australia. Commun Dis Intell 2001; 25 33–47.
| 1:STN:280:DC%2BD3MznsFyguw%3D%3D&md5=76676e86f4938009d84e7b8c5ebff106CAS |

[28]  Doherty RL, Carley JG, Filippich C, White J, Gust ID. Murray Valley encephalitis in Australia, 1974: antibody response in cases and community. Aust N Z J Med 1976; 6 446–53.
Murray Valley encephalitis in Australia, 1974: antibody response in cases and community.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaE2s7otFaisQ%3D%3D&md5=05c9e4a1593ca7d6c65b75f74c22c702CAS |

[29]  Hall RA, Broom AK, Smith DW, Mackenzie JS. The ecology and epidemiology of Kunjin virus. Curr Top Microbiol Immunol 2002; 267 253–69.
| 1:STN:280:DC%2BD38zktVOnsQ%3D%3D&md5=4ef51716394849ccf115773bb0881005CAS |

[30]  Murray K, Selleck P, Hooper P, Hyatt A, Gould A, Gleeson L, et al. A morbillivirus that caused fatal disease in horses and humans. Science 1995; 268 94–7.
A morbillivirus that caused fatal disease in horses and humans.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXkvV2ksLw%3D&md5=2a76fecaed15de826358f2455e32de56CAS |

[31]  Selvey LA, Wells RM, McCormack JG, Ansford AJ, Murray K, Rogers RJ, et al. Infection of humans and horses by a newly described morbillivirus. Med J Aust 1995; 162 642–5.
| 1:STN:280:DyaK2Mzis12qsg%3D%3D&md5=0ca9c827bb5079ccafd77bbab725d98aCAS |

[32]  O'Sullivan JD, Allworth AM, Paterson DL, Snow TM, Boots R, Gleeson LJ, et al. Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet 1997; 349 93–5.
Fatal encephalitis due to novel paramyxovirus transmitted from horses.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2s7kvFKisQ%3D%3D&md5=313b9dc33ce412c92b1dc77cad24af8cCAS |

[33]  Eaton BT, Mackenzie JS, Wang LF. Henipaviruses. In: Knipe DM, Howley PM, editors. Fields Virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. pp. 1587–600.

[34]  Mackenzie JS, Childs JE, Field HE, Wang LF, Breed AC. The role of bats as reservoir hosts of emerging neurological viruses. In: Reiss CS, editor. Neurotropic Viral Infections. Cambridge: Cambridge University Press; 2008. pp. 382–406.

[35]  Halpin K, Young PL, Field HE, Mackenzie JS. Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus. J Gen Virol 2000; 81 1927–32.
| 1:CAS:528:DC%2BD3cXlsFOhtLo%3D&md5=7c528d9cca1f89c66a4eba39e10a78abCAS |

[36]  Li M, Embury-Hyatt C, Weingartl HM. Experimental inoculation study indicates swine as a potential host for Hendra virus. Vet Res 2010; 41 33
Experimental inoculation study indicates swine as a potential host for Hendra virus.Crossref | GoogleScholarGoogle Scholar |

[37]  Luby SP, Rahman M, Hossain MJ, Blum LS, Husain MM, Gurley E, et al. Foodborne transmission of Nipah virus, Bangladesh. Emerg Infect Dis 2006; 12 1888–94.

[38]  Hayman DT, Suu-Ire R, Breed AC, McEachern JA, Wang L, Wood JL, et al. Evidence of henipavirus infection in West African fruit bats. PLoS ONE 2008; 3 e2739
Evidence of henipavirus infection in West African fruit bats.Crossref | GoogleScholarGoogle Scholar |

[39]  Fraser GC, Hooper PT, Lunt RA, Gould AR, Gleeson LJ, Hyatt AD, et al. Encephalitis caused by a Lyssavirus in fruit bats in Australia. Emerg Infect Dis 1996; 2 327–31.
Encephalitis caused by a Lyssavirus in fruit bats in Australia.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2s7isF2gsA%3D%3D&md5=8434f711e233a93a3bdf861f3917bd75CAS |

[40]  Gould AR, Hyatt AD, Lunt R, Kattenbelt JA, Hengstberger S, Blacksell SD. Characterisation of a novel lyssavirus isolated from Pteropid bats in Australia. Virus Res 1998; 54 165–87.
Characterisation of a novel lyssavirus isolated from Pteropid bats in Australia.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXks1Omtbk%3D&md5=482c902e4abaa4eb8dc075713585209eCAS |

[41]  Delmas O, Holmes EC, Talbi C, Larrous F, Dacheux L, Bouchier C, et al. Genomic diversity and evolution of the lyssaviruses. PLoS ONE 2008; 3 e2057
Genomic diversity and evolution of the lyssaviruses.Crossref | GoogleScholarGoogle Scholar |

[42]  Mackenzie JS, Field HE. Emerging encephalitogenic viruses: lyssaviruses and henipaviruses transmitted by frugivorous bats. Arch Virol Suppl 2004; 97–111.
| 1:STN:280:DC%2BD2c3itFeqsw%3D%3D&md5=eb124bad2988a5c1e8517ef9a840683aCAS |

[43]  Ewald B, Durrheim D. Australian Bat Lyssavirus: examination of post-exposure treatment in NSW. N S W Public Health Bull 2008; 19 104–7.
Australian Bat Lyssavirus: examination of post-exposure treatment in NSW.Crossref | GoogleScholarGoogle Scholar |

[44]  McColl KA, Chamberlain T, Lunt RA, Newberry KM, Westbury HA. Susceptibility of domestic dogs and cats to Australian bat lyssavirus (ABLV). Vet Microbiol 2007; 123 15–25.
Susceptibility of domestic dogs and cats to Australian bat lyssavirus (ABLV).Crossref | GoogleScholarGoogle Scholar |

[45]  Hooper P, Lunt R, Gould A, Samaratunga H, Hyatt A, Gleeson L. A new Lyssavirus: the first endemic rabies related virus recognised in Australia. Bull Inst Pasteur 1997; 95 209–18.
A new Lyssavirus: the first endemic rabies related virus recognised in Australia.Crossref | GoogleScholarGoogle Scholar |

[46]  Allworth A, Murray K, Morgan J. A human case of encephalitis due to a lyssavirus recently identified in fruit bats. Commun Dis Intell 1996; 20 504

[47]  Hanna JN, Carney IK, Smith GA, Tannenberg AE, Deverill JE, Botha JA, et al. Australian bat lyssavirus infection: a second human case, with a long incubation period. Med J Aust 2000; 172 597–9.
| 1:STN:280:DC%2BD3czpvVShsA%3D%3D&md5=da859c9d1ef6e317433dafe328fb7c9dCAS |

[48]  Brookes SM, Parsons G, Johnson N, McElhinney LM, Fooks AR. Rabies human diploid cell vaccine elicits cross-neutralising and cross-protecting immune responses against European and Australian bat lyssaviruses. Vaccine 2005; 23 4101–9.
Rabies human diploid cell vaccine elicits cross-neutralising and cross-protecting immune responses against European and Australian bat lyssaviruses.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXlt1Kjtr8%3D&md5=8af3c99f6b85c42d62103c37f71f7a15CAS |

[49]  Rupprecht CE, Gibbons RV. Clinical practice. Prophylaxis against rabies. N Engl J Med 2004; 351 2626–35.
Clinical practice. Prophylaxis against rabies.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXhtV2qtbfP&md5=8d311582144287f92cbd947a6b002f81CAS |

[50]  Weaver SC, Reisen WK. Present and future arboviral threats. Antiviral Res 2010; 85 328–45.
Present and future arboviral threats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtVejsrg%3D&md5=9d1e128f5e9baad881a80bf1ff9e5ad5CAS |

[51]  Barclay AJ, Paton DJ. Hendra (equine morbillivirus). Vet J 2000; 160 169–76.
Hendra (equine morbillivirus).Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3M7gt1WnsA%3D%3D&md5=7d50042ead5f973914945376a68c891bCAS |

[52]  Samaratunga H, Searle JW, Hudson N. Non-rabies Lyssavirus human encephalitis from fruit bats: Australian bat Lyssavirus (pteropid Lyssavirus) infection. Neuropathol Appl Neurobiol 1998; 24 331–5.
Non-rabies Lyssavirus human encephalitis from fruit bats: Australian bat Lyssavirus (pteropid Lyssavirus) infection.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1cvkvVGhtw%3D%3D&md5=fa4e656e2a668c0b20ae689466ed69bbCAS |

[53]  Mackenzie JS. Emerging zoonotic encephalitis viruses: lessons from Southeast Asia and Oceania. J Neurovirol 2005; 11 434–40.
Emerging zoonotic encephalitis viruses: lessons from Southeast Asia and Oceania.Crossref | GoogleScholarGoogle Scholar |

[54]  Huppatz C, Gawarikar Y, Levi C, Kelly PM, Williams D, Dalton C, et al. Should there be a standardised approach to the diagnostic workup of suspected adult encephalitis? A case series from Australia. BMC Infect Dis 2010; 10 353
Should there be a standardised approach to the diagnostic workup of suspected adult encephalitis? A case series from Australia.Crossref | GoogleScholarGoogle Scholar |

[55]  Whitley RJ, Gnann JW. Viral encephalitis: familiar infections and emerging pathogens. Lancet 2002; 359 507–13.
Viral encephalitis: familiar infections and emerging pathogens.Crossref | GoogleScholarGoogle Scholar |

[56]  Australian Government Department of Health and Ageing. National Notifiable Diseases Surveillance System. Available from: http://www9.health.gov.au/cda/source/CDA-index.cfm (Cited 15 June 2011.)

[57]  Government of Western Australia Department of Health. Mosquito-borne disease risk extends to south-central regions of WA. Media Release 16 May 2011. Available from: http://www.health.wa.gov.au/press/view_press.cfm?id=994 (Cited 15 June 2011.)

[58]  SA Health. Murray Valley encephalitis. Media Release, 3 May 2011. Available from: http://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/health+information/news/media+releases/murray+valley+encephalitis (Cited 15 June 2011.)

[59]  ProMED-mail. Murray Valley encephalitis – Australia (07): Canada ex Australia (Northern Territory). 26 May 2011. Archive 20110526.1610. Available from: http:www.promedmail.org (Cited 15 June 2011.)