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Australian Journal of Chemistry Australian Journal of Chemistry Society
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Porphyrazines: Designer Macrocycles by Peripheral Substituent Change

Matthew J. Fuchter A , Chang Zhong B , Hong Zong B , Brian M. Hoffman B and Anthony G. M. Barrett C D
+ Author Affiliations
- Author Affiliations

A Department of Biological and Pharmaceutical Chemistry, School of Pharmacy, University of London, 29–39 Brunswick Square, London WC1N 1AX, UK.

B Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

C Department of Chemistry, Imperial College London, London SW7 2AZ, UK.

D Corresponding author. Email: agmb@imperial.ac.uk




Matthew Fuchter underwent undergraduate studies at the University of Bristol, where he was awarded the Richard N. Dixon prize. Following this, he completed his Ph.D. under the supervision of Professor A. G. M. Barrett, at Imperial College London. Following a short postdoctoral spell at Imperial College, Dr. Fuchter was appointed as a Research Fellow at the Commonwealth Scientific and Industrial Research Organisation, Australia as well as a visiting fellow at the University of Melbourne, where he worked with Professor A. B. Holmes. Currently he is a RCUK Academic Fellow at The School of Pharmacy, University of London. His research interests include: the development of innovative methods in organic synthesis, and the preparation of novel anti-cancer therapeutics.



Chang Zhong went to the University of Science and Technology of China as an undergraduate, and then received his Ph.D. from Northwestern University under the direction of Dr. Brian Hoffman, and thence to the Los Alamos National Laboratory as a LDRD Postdoctoral Fellow with Dr. Jennifer Martinez and Dr. R. Brian Dyer. His research interests include: preparing fluorescent metallic nanoclusters through dendrimer, polymer, peptide, and protein templates; studying the bio-effect of fullerene derivatives; as well as the preparation/characterization of multimetallic porphyrazines.



Hong Zong is a postdoctoral fellow at Northwestern University. He received his B.Sc. in Chemistry from Fudan University (China) in 1997 and an M.E. in Materials Science from the Chinese Academy of Sciences in 2000. He went on to join the group of Professor Brian M. Hoffman at Northwestern University to study porphyrazines as tumour contrast agents and surface-bound molecules, for which he received his Ph.D. in 2007. His current research focuses on the development of bifunctional PDT and MRI contrast agents.



Brian Hoffman was born in Chicago, as an undergraduate went to the University of Chicago, then wandered to the west coast for a Ph.D. from Caltech under the direction of Dr. Harden McConnell, and thence to the east coast for a postdoctoral year with Dr. Alex Rich at MIT. From there he joined the faculty at Northwestern University, where he is a Professor in the Chemistry and BMBCB departments. His research interests include: electronuclear double resonance (endor) of metallobiomolecules; electron transfer within protein complexes; as well as the preparation/characterization of porphyrazine macrocycles.



Tony Barrett obtained his Ph.D. (1975) with Professor Sir Derek H. R. Barton and was appointed as Lecturer (1975) and Senior Lecturer (1982) at Imperial College. At the age of 31 he was appointed a full Professor of Chemistry at Northwestern University, Evanston, IL (1983) and Colorado State University (1990). In 1993 he returned to his alma mater, Imperial College as Glaxo Professor of Chemistry, Sir Derek Barton Professor of Synthesis, Director of the Wolfson Centre for Organic Chemistry in Medical Science and Head of Synthesis. His research interests include the total synthesis of bioactive natural products, porphyrazine chemistry, the design of methods for organic synthesis including novel catalysis, enantioselective transformations and supported reagents and cancer medicinal chemistry.

Australian Journal of Chemistry 61(4) 235-255 https://doi.org/10.1071/CH07445
Submitted: 24 December 2007  Accepted: 22 February 2008   Published: 24 April 2008



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