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Natural Inhibitors of Snake Venom Metalloproteinases

Narumi Aoki-Shioi https://orcid.org/0000-0001-8326-6856 A B D , Cho Yeow Koh C and R. Manjunatha Kini B
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A Department of Chemistry, Faculty of Science, Fukuoka University, 19-1, 8-chome Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

B Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore.

C Department of Medicine, Yong Loo Lin School of Medicine, 14 Medical Drive, MD6, Singapore 117599, Republic of Singapore.

D Corresponding author. Email: anarumi@fukuoka-u.ac.jp




Assistant Professor Narumi Aoki-Shioi works in the Department of Chemistry, Faculty of Science, Fukuoka University in Japan. Her research interest is new functional proteins and peptides from venomous snakes and their uses. Her research focuses on functional analysis of snake venom metalloprotease, discovery of endogenous inhibitors from venomous snakes, and analysis of their inhibitory mechanisms for development into therapeutics for snake envenomation. She has written 15 original research papers, four reviews, and one book chapter.



Dr Cho Yeow Koh is a Research Assistant Professor in the Department of Medicine, University of Singapore. He has strong interest in drug discovery and development research related to cardiovascular and neglected tropical diseases. He explores venomous and haematophagous animals for novel molecules that may be developed into therapeutics, medical technologies or research tools. Dr Koh has written 23 peer-reviewed scientific papers and two book chapters, and has eight patents in his name.



Professor R. Manjunatha Kini of the Department of Biological Sciences, National University of Singapore, is a leading authority on structure-function relationships of proteins from venomous animals, especially snakes. He has many years of experience in protein chemistry, biophysics, protein and peptide design and engineering. He has published more than 255 original research papers, reviews and book chapters. He also has 50 patent applications and started two small biotechnology companies. He is the President of the International Society of Toxinology, Vice President of the International Proteolysis Society, and the Editor-in-Chief of Toxin Reviews.

Australian Journal of Chemistry 73(4) 277-286 https://doi.org/10.1071/CH19414
Submitted: 21 September 2019  Accepted: 8 January 2020   Published: 5 March 2020



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