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The extracellular chaperone clusterin prevents primary and secondary nucleation of an amyloidogenic variant of β2-microglobulin
Manjeet Kumar A H , Cristina Cantarutti B , David C. Thorn A I , Vittorio Bellotti C D , Gennaro Esposito E F , Mark R. Wilson G , Heath Ecroyd G and John A. Carver A *A Research School of Chemistry, The Australian National University, Acton, ACT 2601, Australia.
B Department of Medicine, University of Udine, 33100 Udine, Italy.
C Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK.
D Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100 Pavia, Italy.
E Science & Math Division, New York University Abu Dhabi, Abu Dhabi, UAE.
F Istituto Nazionale Biomolecole e Biostrutture, 00136 Rome, Italy.
G Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
H Present address: Department of Biophysics and Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, USA.
I Present address: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Australian Journal of Chemistry 76(10) 696-708 https://doi.org/10.1071/CH23082
Submitted: 30 April 2023 Accepted: 19 June 2023 Published: 11 July 2023