Register      Login
Reproduction, Fertility and Development Reproduction, Fertility and Development Society
Vertebrate reproductive science and technology

Antiandrogens as environmental endocrine disruptors¤

W. R. Kelce, L. E. Gray and E. M. Wilson

Reproduction, Fertility and Development 10(1) 105 - 112
Published: 1998


Steroid hormone receptors control fundamental events in embryonic development and sex differentiation through their function as ligand-inducible transcription factors. The consequences of disrupting these processes can be especially profound during development due to the crucial role hormones play in controlling transient and irreversible developmental processes. Several environmental chemicals, including metabolites of the fungicide vinclozolin and the pesticide DDT, disrupt male reproductive development and function by inhibiting androgen receptor mediated events. A variety of in vitro and in vivo approaches have been used to determine the molecular basis of environmental antiandrogen toxicity. These chemicals commonly bind androgen receptor with moderate affinity and act as antagonists by inhibiting transcription of androgen dependent genes.

© CSIRO 1998

Committee on Publication Ethics

Rent Article (via Deepdyve) Export Citation Cited By (116) Get Permission

View Dimensions

View Altmetrics