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Article << Previous     |     Next >>   Contents Vol 25(6)

Chronic treatment of female tammar wallabies with deslorelin implants during pouch life: effects on reproductive maturation

C. A. Herbert A D H , D. C. Eckery B E , T. E. Trigg C F and D. W. Cooper G

A School of Biological Sciences, Macquarie University, NSW 2109, Australia.
B AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt 5140, New Zealand.
C Peptech Animal Health Pty Limited, Locked Bag 441, North Ryde, NSW 1670, Australia.
D Present address: Faculty of Veterinary Science, The University of Sydney, Sydney, NSW 2006, Australia.
E Present address: School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
F Present address: PT Consulting Pty Limited, Balmain, NSW 2041, Australia.
G Deceased. Formerly of School of Biological Sciences, Macquarie University, NSW 2109, Australia.
H Corresponding author. Email: catherine.herbert@sydney.edu.au

Reproduction, Fertility and Development 25(6) 879-889 http://dx.doi.org/10.1071/RD12087
Submitted: 19 March 2012  Accepted: 25 July 2012   Published: 17 September 2012


 
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Abstract

The present study reports on attempts to delay puberty in a model marsupial species using the gonadotrophin-releasing hormone (GnRH) agonist deslorelin. Female tammar wallaby pouch young received deslorelin (5 mg) or placebo implants (n = 8/group) when they were 193 ± 2 days old. Sexual maturity was significantly delayed in deslorelin-treated animals, with the first successful production of offspring in treated and control animals occurring at 813 ± 62 and 430 ± 42 days of age, respectively. This delay was associated with a period of retarded pouch and teat development. Progesterone concentrations remained at basal levels throughout the first breeding season, indicating the absence of luteal cycles in treated females. Recovery and maturation of the hypothalamic–pituitary axis was a gradual process. Treated animals failed to respond to GnRH challenge at 12 months of age and had a reduced LH response at 18 months of age, before attaining full responsiveness by 24 months of age. Despite this apparent pituitary recovery by 24 months of age, as evidenced by complete teat eversion and LH responsiveness to GnRH, the time to first parturition was significantly delayed beyond this time in three females. This suggests that there may be longer-lasting effects at the level of the ovary and/or on FSH secretion. The significant delay in the onset of sexual maturation in response to chronic GnRH agonist treatment in this model marsupial species may be of practical significance to the management of fertility in captive and semi-free range marsupial populations.

Additional keywords: contraception, fertility control, macropod, Suprelorin.


References

Bertschinger, H. J., de Barros Vaz Guimarães, M. A., Trigg, T. E., and Human, A. (2008). The use of deslorelin implants for the long-term contraception of lionesses and tigers. Wildl. Res. 35, 525–530.
CrossRef | CAS |

Brown, B. W., Mattner, P. E., Carroll, P. A., Hoskinson, R. M., and Rigby, R. D. (1995). Immunization of sheep against GnRH early in life: effects on reproductive function and hormones in ewes. J. Reprod. Fertil. 103, 131–135.
CrossRef | CAS | PubMed |

Clarke, I. J., Brown, B. W., Tran, V. V., Scott, C. J., Fry, R., Millar, R. P., and Rao, A. (1998). Neonatal immunization against gonadotropin-releasing hormone (GnRH) results in diminished GnRH secretion in adulthood. Endocrinology 139, 2007–2014.
CrossRef | CAS | PubMed |

Currie, W., Ellis, K., Gourley, S., Joseph, I., Cook, S., and Rawlings, N. (1993). Luteinizing and follicle-stimulating hormone secretion during median eminence perfusion or intravenous infusion with gonadotrophin-releasing hormone antisera in ovariectomized ewes. Anim. Reprod. Sci. 31, 277–285.
CrossRef | CAS |

Duka, T., and Masters, P. (2005). Confronting a tough issue: fertility control and translocation for over-abundant koalas on Kangaroo Island, South Australia. Ecol. Manage. Restor. 6, 172–181.
CrossRef |

Evans, A., and Rawlings, N. (1994). Effects of a long-acting gonadotrophin-releasing hormone agonist (Leuprolide) on ovarian follicular development in prepubertal heifer calves. Can. J. Anim. Sci. 74, 649–656.
CrossRef | CAS |

Herbert, C. (2007). From the urban fringe to the Abrolhos Islands: management challenges of burgeoning marsupial populations. In ‘Pest or Guest: The Zoology of Overabundance’. (Eds D. Lunney, P. Eby, P. Hutchings and S. Burgin.) pp. 129–141. (Royal Zoological Society New South Wales: Mosman, NSW.)

Herbert, C. A., and Trigg, T. E. (2005). Applications of GnRH in the control and management of fertility in female animals. Anim. Reprod. Sci. 88, 141–153.
CrossRef | CAS | PubMed |

Herbert, C. A., Trigg, T. E., and Cooper, D. W. (2004a). Effect of deslorelin implants on follicular development, parturition and post-partum oestrus in the tammar wallaby (Macropus eugenii). Reproduction 127, 265–273.
CrossRef | CAS | PubMed |

Herbert, C. A., Trigg, T. E., Renfree, M. B., Shaw, G., Eckery, D. C., and Cooper, D. W. (2004b). Effects of a gonadotropin-releasing hormone agonist implant on reproduction in a male marsupial, Macropus eugenii. Biol. Reprod. 70, 1836–1842.
CrossRef | CAS | PubMed |

Herbert, C. A., Trigg, T., Renfree, M., Shaw, G., Eckery, D., and Cooper, D. (2005). Long-term effects of deslorelin implants on reproduction in the female tammar wallaby (Macropus eugenii). Reproduction 129, 361–369.
CrossRef | CAS | PubMed |

Herbert, C. A., Trigg, T. E., and Cooper, D. W. (2006). Fertility control in female eastern grey kangaroos using the GnRH agonist deslorelin. 1. Effects on reproduction. Wildl. Res. 33, 41–46.
CrossRef | CAS |

Herbert, C. A., Eckery, D. C., Trigg, T. E., and Cooper, D. W. (2007). Chronic treatment of male tammar wallabies with deslorelin implants during pouch life: effects on development, puberty, and reproduction in adulthood. Biol. Reprod. 76, 1054–1061.
CrossRef | CAS | PubMed |

Herbert, C. A., Renfree, M. B., Coulson, G., Shaw, G., Trigg, T. E., and Cooper, D. W. (2010). Advances in fertility control technologies for managing overabundant macropodid populations. In ‘Macropods: The Biology of Kangaroos, Wallabies and Rat Kangaroos’. (Eds G. Coulson and M. D. B. Eldridge.) pp. 313–324. (CSIRO: Collingwood, Vic.)

Kirkpatrick, T. (1965). Studies of Macropodidae in Queensland. 3. Reproduction in the grey kangaroo (Macropus major) in southern Queensland. Queensl. J. Agric. Anim. Sci. 22, 319–328.

Lacoste, D., Dube, D., Trudel, C., Belanger, A., and Labrie, F. (1989). Normal gonadal functions and fertility after 23 months of treatment of prepubertal male and female dogs with the GnRH agonist [d-Trp6, des-Gly-NH210]GnRH ethylamide. J. Androl. 10, 456–465.
| CAS | PubMed |

McLean, N., and Handasyde, K. A. (2006). Sexual maturity, factors affecting the breeding season and breeding in consecutive seasons in populations of overabundant Victorian koalas (Phascolarctos cinereus). Aust. J. Zool. 54, 385–392.
CrossRef |

Moore, L. G., Chie, W. N., Lun, S., Lawrence, S. B., Heath, D. A., and McNatty, K. P. (1997). Isolation, characterization and radioimmunoassay of luteinizing hormone in the brushtail possum. Reprod. Fertil. Dev. 9, 419–425.
CrossRef | CAS | PubMed |

Munson, L., Bauman, J., Asa, C., Jöchle, W., and Trigg, T. (2001). Efficacy of the GnRH analogue deslorelin for suppression of oestrous cycles in cats. J. Reprod. Fertil. 57, 269–273.
| CAS |

National Health and Medical Research Council (2004). ‘Australian Code of Practice for the Care and Use of Animals for Scientific Purposes.’ (Australian Government: Canberra.)

Nurse, S. C., and Renfree, M. B. (1994). Pubertal development of the pouch and teats in the marsupial Macropus eugenii. J. Reprod. Fertil. 101, 279–285.
CrossRef | CAS | PubMed |

Poole, W. E. (1973). A study of breeding in grey kangaroos, Macropus giganteus Shaw and M. fuliginosus (Desmarest), in central New South Wales. Aust. J. Zool. 21, 183–212.
CrossRef | CAS | PubMed |

Poole, W. (1983). Breeding in the grey kangaroo, Macropus giganteus, from widespread locations in eastern Australia. Wildl. Res. 10, 453–466.
CrossRef |

Poole, W., and Catling, P. (1974). Reproduction in the two species of grey kangaroo, Macropus giganteus Shaw and M. fuliginosus (Desmarest) I. Sexual maturity and oestrus. Aust. J. Zool. 22, 277–302.
CrossRef | CAS | PubMed |

Poole, W., Simms, N., Wood, J., and Lubulwa, M. (1991). ‘Tables for Age Determination of the Kangaroo Island Wallaby (tammar), Macropus eugenii.’ Technical Memorandum No. 32. (CSIRO Division of Wildlife and Ecology: Canberra.)

Renfree, M. B., Short, R., and Shaw, G. (1996). Sexual differentiation of the urogenital system of the fetal and neonatal tammar wallaby, Macropus eugenii. Anat. Embryol. 194, 111–134.
CrossRef | CAS | PubMed |

Rubion, S., Desmoulins, P. O., Rivière-Godet, E., Kinziger, M., Salavert, F., Rutten, F., Flochlay-Sigognault, A., and Driancourt, M. A. (2006). Treatment with a subcutaneous GnRH agonist containing controlled release device reversibly prevents puberty in bitches. Theriogenology 66, 1651–1654.
CrossRef | CAS | PubMed |

Shaw, G., and Renfree, M. B. (1984). Concentrations of oestradiol-17 in plasma and corpora lutea throughout pregnancy in the tammar, Macropus eugenii. J. Reprod. Fertil. 72, 29–37.
CrossRef | CAS | PubMed |

SPSS Inc (2007). ‘SPSS Statistics Base 17.0 User’s Guide.’ (SPSS Inc.: Chicago, IL.)

Trigg, T., Wright, P., Armour, A., Williamson, P. E., Junaidi, A., Martin, G. B., Doyle, A. G., and Walsh, J. (2001). Use of a GnRH analogue implant to produce reversible long-term suppression of reproductive function in male and female domestic dogs. J. Reprod. Fertil. Suppl. 57, 255–261.
| CAS | PubMed |

Wettemann, R., and Castree, J. (1994). Immunization of heifers against gonadotropin releasing hormone delays puberty and causes the cessation of estrous cycles. Anim. Reprod. Sci. 36, 49–59.
CrossRef | CAS |

Williams, S. C., Fletcher, T., and Renfree, M. B. (1998). Puberty in the female tammar wallaby. Biol. Reprod. 58, 1117–1122.
CrossRef | CAS | PubMed |

Zeng, X. Y., Turkstra, J. A., Tsigos, A., Meloen, R. H., Liu, X. Y., Chen, F. Q., Schaaper, W. M. M., Oonk, H. B., Guo, D. Z., and van de Wiel, D. F. M. (2002). Effects of active immunization against GnRH on serum LH, inhibin A, sexual development and growth rate in Chinese female pigs. Theriogenology 58, 1315–1326.
CrossRef | CAS | PubMed |


   
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