RD25054Transcription factor-mediated gene regulatory networks in the formation of oocytes
Female infertility impacts millions globally, prompting the exploration of stem cell-derived oocyte technologies as a transformative solution. Cross-species research has identified NFYA/B/C as core regulators of oogenesis, with NFYA demonstrating a remarkable ability to activate the key oocyte-specific gene Alkbh5. This breakthrough promises to elevate the efficiency of in vitro oocyte production while establishing theoretical foundations for novel infertility treatments. Diagram by Shu Fang.