Sperm abnormalities are commonly reported in men with high leptin levels. This review examines the literature to ascertain a link between leptin and abnormal sperm parameters. Evidence suggests that leptin impacts sperm, and is probably responsible for the sperm abnormalities in men with raised leptin levels.

Sulfasalazine (SAS) is a drug used by pregnant and breastfeeding women for the treatment of chronic inflammatory rheumatic and bowel diseases. However, SAS crosses the placenta and is also transferred into breast milk. This study shows that maternal SAS exposure during gestational and lactational periods induced histological alterations in the testis and epididymis during puberty and, oxidative stress-related changes in the testis of infants and adolescent rats providing information on SAS treatment during critical windows of development.