Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
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Benzyne Chemistry

In this Research Front, the history of o-benzyne from its early beginnings as an unobservable reactive intermediate until its present status as a very well characterized but still theoretically challenging molecule with important applications in synthesis is reviewed. The m- and p-benzynes, tridehydrobenzenes, and benzdiynes are also known, and p-benzyne is a key intermediate in the action of a potent class of ene-diyne anti-tumour compounds.
Published 15 July 2010

The Benzyne Story

Curt Wentrup
Australian Journal of Chemistry 63 (7) pp.979 - 986