References

Aggerholm, A. S., Thulstrup, A. M., Toft, G., Ramlau-Hansen, C. H., and Bonde, J. P. (2008). Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertil. Steril. 90, 619–626.
| CrossRef | CAS |

Avise, J. C., Lansman, R. A., and Shade, R. O. (1979). The use of restriction endonucleases to measure mitochondrial DNA sequence relatedness in natural populations. I. Population structure and evolution in the genus Peromyscus. Genetics 92, 279–295.
| CAS |

Bakos, H. W., Mitchell, M., Setchell, B. P., and Lane, M. (2010). The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model. Int. J. Androl. 34, 402–410.
| CrossRef |

Bakos, H. W., Henshaw, R. C., Mitchell, M., and Lane, M. (2011). Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertil. Steril. 95, 1700–1704.
| CrossRef |

Bellance, N., Benard, G., Furt, F., Begueret, H., Smolkova, K., Passerieux, E., Delage, J. P., Baste, J. M., Moreau, P., and Rossignol, R. (2009). Bioenergetics of lung tumors: alteration of mitochondrial biogenesis and respiratory capacity. Int. J. Biochem. Cell. Biol. 41, 2566–2577.
| CrossRef | CAS |

Bellver, J., Rossal, L. P., Bosch, E., Zuniga, A., Corona, J. T., Melendez, F., Gomez, E., Simon, C., Remohi, J., and Pellicer, A. (2003). Obesity and the risk of spontaneous abortion after oocyte donation. Fertil. Steril. 79, 1136–1140.
| CrossRef |

Bellver, J., Ayllon, Y., Ferrando, M., Melo, M., Goyri, E., Pellicer, A., Remohi, J., and Meseguer, M. (2010). Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil. Steril. 93, 447–454.
| CrossRef |

Carrell, D. T., Jones, K. P., Peterson, C. M., Aoki, V., Emery, B. R., and Campbell, B. R. (2001). Body mass index is inversely related to intrafollicular HCG concentrations, embryo quality and IVF outcome. Reprod. Biomed. Online 3, 109–111.
| CrossRef | CAS |

Chavarro, J. E., Toth, T. L., Wright, D. L., Meeker, J. D., and Hauser, R. (2009). Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil. Steril. 93, 2222–2231.
| CrossRef |

Dokras, A., Baredziak, L., Blaine, J., Syrop, C., VanVoorhis, B. J., and Sparks, A. (2006). Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet. Gynecol. 108, 61–69.
| CrossRef |

Fedorcsák, P., Storeng, R., Dale, P. O., Tanbo, T., and Åbyholm, T. (2000). Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet. Gynecol. Scand. 79, 43–48.
| CrossRef |

Fedorcsák, P., Dale, P. O., Storeng, R., Ertzeid, G., Bjercke, S., Oldereid, N., Omland, A. K., Åbyholm, T., and Tanbo, T. (2004). Impact of overweight and underweight on assisted reproduction treatment. Hum. Reprod. 19, 2523–2528.
| CrossRef |

Fejes, I., Koloszar, S., Szollosi, J., Zavaczki, Z., and Pal, A. (2005). Is semen quality affected by male body fat distribution? Andrologia 37, 155–159.
| CrossRef | CAS |

Gardner, D. K. (1998). Changes in requirements and utilization of nutrients during mammalian preimplantation embryo development and their significance in embryo culture. Theriogenology 49, 83–102.
| CrossRef | CAS |

Gardner, D. K., and Lane, M. (2007). Embryo culture systems. In ‘In Vitro Fertilization: A Practical Approach’. (Ed. D. K. Gardner.) pp. 221–282. (Informa Healthcare: New York.)

Gardner, D. K., and Leese, H. J. (1987). Assessment of embryo viability prior to transfer by the noninvasive measurement of glucose uptake. J. Exp. Zool. 242, 103–105.
| CrossRef | CAS |

Gardner, D. K., and Leese, H. J. (1990). Concentrations of nutrients in mouse oviduct fluid and their effects on embryo development and metabolism in vitro. J. Reprod. Fertil. 88, 361–368.
| CrossRef | CAS |

Garesse, R., and Vallejo, C. G. (2001). Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes. Gene 263, 1–16.
| CrossRef | CAS |

Giles, R. E., Blanc, H., Cann, H. M., and Wallace, D. C. (1980). Maternal inheritance of human mitochondrial DNA. Proc. Natl Acad. Sci. USA 77, 6715–6719.
| CrossRef | CAS |

Hammoud, A. O., Wilde, N., Gibson, M., Parks, A., Carrell, D. T., and Meikle, A. W. (2008). Male obesity and alteration in sperm parameters. Fertil. Steril. 90, 2222–2225.
| CrossRef |

Honnma, H., Endo, T., Kiya, T., Shimizu, A., Nagasawa, K., Baba, T., Fujimoto, T., Henmi, H., Kitajima, Y., Manase, K., Ishioka, S., Ito, E., and Saito, T. (2010). Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty (fa/fa) rats. Reprod. Biol. Endocrinol. 8, 73–81.
| CrossRef |

Igosheva, N., Abramov, A. Y., Poston, L., Eckert, J. J., Fleming, T. P., Duchen, M. R., and McConnell, J. (2010). Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS ONE 5, e10074.
| CrossRef |

James, P. T., Rigby, N., and Leach, R. (2004). The obesity epidemic, metabolic syndrome and future prevention strategies. Eur. J. Cardiovasc. Prev. Rehabil. 11, 3–8.
| CrossRef |

Jensen, T. K., Andersson, A. M., Jorgensen, N., Andersen, A. G., Carlsen, E., Petersen, J. H., and Skakkebaek, N. E. (2004). Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil. Steril. 82, 863–870.
| CrossRef | CAS |

Kenigsberg, S., Bentov, Y., Chalifa-Caspi, V., Potashnik, G., Ofir, R., and Birk, O. S. (2009). Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients. Mol. Hum. Reprod. 15, 89–103.
| CrossRef | CAS |

Kort, H. I., Massey, J. B., Elsner, C. W., Mitchell-Leef, D., Shapiro, D. B., Witt, M. A., and Roudebush, W. E. (2006). Impact of body mass index values on sperm quantity and quality. J. Androl. 27, 450–452.
| CrossRef |

Ku, S. Y., Kim, S. D., Jee, B. C., Suh, C. S., Choi, Y. M., Kim, J. G., Moon, S. Y., and Kim, S. H. (2006). Clinical efficacy of body mass index as predictor of in vitro fertilization and embryo transfer outcomes. J. Korean Med. Sci. 21, 300–303.
| CrossRef |

Kupka, M. S., Gnoth, C., Buehler, K., Dahncke, W., and Kruessel, J. S. (2011). Impact of female and male obesity on IVF/ICSI: results of 700,000 ART-cycles in Germany. Gynecol. Endocrinol. 27, 144–149.
| CrossRef |

Lane, M., and Gardner, D. K. (1996). Selection of viable mouse blastocysts prior to transfer using a metabolic criterion. Hum. Reprod. 11, 1975–1978.
| CAS |

Lane, M., and Gardner, D. K. (1997). Differential regulation of mouse embryo development and viability by amino acids. J. Reprod. Fertil. 109, 153–164.
| CrossRef | CAS |

Lane, M., and Gardner, D. K. (2000). Lactate regulates pyruvate uptake and metabolism in the preimplantation mouse embryo. Biol. Reprod. 62, 16–22.
| CrossRef | CAS |

Lane, M., and Gardner, D. K. (2003). Ammonium induces aberrant blastocyst differentiation, metabolism, pH regulation, gene expression and subsequently alters fetal development in the mouse. Biol. Reprod. 69, 1109–1117.
| CrossRef | CAS |

Lane, M., and Gardner, D. K. (2004). Preparation of gametes, in vitro maturation, in vitro fertilization, embryo recovery and transfer. In ‘A Laboratory Guide to the Mammalian Embryo’. (Eds D. K. Gardner, M. Lane and A. J. Watson.) pp. 24–40. (Oxford University Press: New York.)

Lashen, H., Fear, K., and Sturdee, D. W. (2004). Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum. Reprod. 19, 1644–1646.
| CrossRef | CAS |

Latham, K. E., and Schultz, R. M. (2001). Embryonic genome activation. Front. Biosci. 6, d748–d759.
| CrossRef | CAS |

Leese, H. J., and Barton, A. M. (1984). Pyruvate and glucose uptake by mouse ova and preimplantation embryos. J. Reprod. Fertil. 72, 9–13.
| CrossRef | CAS |

Loveland, J. B., McClamrock, H. D., Malinow, A. M., and Sharara, F. I. (2001). Increased body mass index has a deleterious effect on in vitro fertilization outcome. J. Assist. Reprod. Genet. 18, 382–386.
| CrossRef | CAS |

Magnusdottir, E. V., Thorsteinsson, T., Thorsteinsdottir, S., Heimisdottir, M., and Olafsdottir, K. (2005). Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum. Reprod. 20, 208–215.
| CrossRef |

Metwally, M., Cutting, R., Tipton, A., Skull, J., Ledger, W. L., and Li, T. C. (2007). Effect of increased body mass index on oocyte and embryo quality in IVF patients. Reprod. Biomed. Online 15, 532–538.
| CrossRef | CAS |

Metwally, M., Ong, K. J., Ledger, W. L., and Li, T. C. (2008). Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil. Steril. 90, 714–726.
| CrossRef |

Minge, C. E., Bennett, B. D., Norman, R. J., and Robker, R. L. (2008). Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality. Endocrinology 149, 2646–2656.
| CrossRef | CAS |

Mitchell, M., Bakos, H. W., and Lane, M. (2011). Paternal diet-induced obesity impairs embryo development and implantation in the mouse. Fertil. Steril. 95, 1349–1353.
| CrossRef |

Nichols, J. E., Crane, M. M., Higdon, H. L., Miller, P. B., and Boone, W. R. (2003). Extremes of body mass index reduce in vitro fertilization pregnancy rates. Fertil. Steril. 79, 645–647.
| CrossRef |

Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., and Flegal, K. M. (2006). Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295, 1549–1555.
| CrossRef | CAS |

Pauli, E. M., Legro, R. S., Demers, L. M., Kunselman, A. R., Dodson, W. C., and Lee, P. A. (2008). Diminished paternity and gonadal function with increasing obesity in men. Fertil. Steril. 90, 346–351.
| CrossRef | CAS |

Qin, D. D., Yuan, W., Zhou, W. J., Cui, Y. Q., Wu, J. Q., and Gao, E. S. (2007). Do reproductive hormones explain the association between body mass index and semen quality? Asian J. Androl. 9, 827–834.
| CrossRef | CAS |

Ramlau-Hansen, C. H., Thulstrup, A. M., Nohr, E. A., Bonde, J. P., Sorensen, T. I., and Olsen, J. (2007). Subfecundity in overweight and obese couples. Hum. Reprod. 22, 1634–1637.
| CrossRef | CAS |

Renard, J. P., Philippon, A., and Menezo, Y. (1980). In-vitro uptake of glucose by bovine blastocysts. J. Reprod. Fertil. 58, 161–164.
| CrossRef | CAS |

Robker, R. L., Akison, L. K., Bennett, B. D., Thrupp, P. N., Chura, L. R., Russell, D. L., Lane, M., and Norman, R. J. (2009). Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J. Clin. Endocrinol. Metab. 94, 1533–1540.
| CrossRef | CAS |

Seshagiri, P. B., and Bavister, B. D. (1991). Glucose and phosphate inhibit respiration and oxidative metabolism in cultured hamster eight-cell embryos: evidence for the ‘crabtree effect’. Mol. Reprod. Dev. 30, 105–111.
| CrossRef | CAS |

Taylor, K. D., and Piko, L. (1995). Mitochondrial biogenesis in early mouse embryos: expression of the mRNAs for subunits IV, Vb, and VIIc of cytochrome c oxidase and subunit 9 (P1) of H(+)-ATP synthase. Mol. Reprod. Dev. 40, 29–35.
| CrossRef | CAS |

van der Steeg, J. W., Steures, P., Eijkemans, M. J., Habbema, J. D., Hompes, P. G., Burggraaff, J. M., Oosterhuis, G. J., Bossuyt, P. M., van der Veen, F., and Mol, B. W. (2008). Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum. Reprod. 23, 324–328.
| CrossRef |

van Swieten, E. C., van der Leeuw-Harmsen, L., Badings, E. A., and van der Linden, P. J. (2005). Obesity and clomiphene challenge test as predictors of outcome of in vitro fertilization and intracytoplasmic sperm injection. Gynecol. Obstet. Invest. 59, 220–224.
| CrossRef |

Villamor, E., and Cnattingius, S. (2006). Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. Lancet 368, 1164–1170.
| CrossRef |

Virant-Klun, I., Tomazevic, T., and Meden-Vrtovec, H. (2002). Sperm single-stranded DNA, detected by acridine orange staining, reduces fertilization and quality of ICSI-derived embryos. J. Assist. Reprod. Genet. 19, 319–328.
| CrossRef |

Wale, P. L., and Gardner, D. K. (2010). Time-lapse analysis of mouse embryo development in oxygen gradients. Reprod. Biomed. Online 21, 402–410.
| CrossRef | CAS |

Wang, J. X., Davies, M., and Norman, R. J. (2000). Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study. BMJ 321, 1320–1321.
| CrossRef | CAS |

Wittemer, C., Ohl, J., Bailly, M., Bettahar-Lebugle, K., and Nisand, I. (2000). Does body mass index of infertile women have an impact on IVF procedure and outcome? J. Assist. Reprod. Genet. 17, 547–552.
| CrossRef | CAS |