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Vertebrate reproductive science and technology
RESEARCH ARTICLE

Parental diet, pregnancy outcomes and offspring health: metabolic determinants in developing oocytes and embryos

Kevin D. Sinclair A B and Adam J. Watkins A
+ Author Affiliations
- Author Affiliations

A School of Biosciences, University of Nottingham, Sutton Bonington, Leicestershire, LE12 5RD, UK.

B Corresponding author. Email: kevin.sinclair@nottingham.ac.uk

Reproduction, Fertility and Development 26(1) 99-114 https://doi.org/10.1071/RD13290
Published: 5 December 2013

Abstract

The periconceptional period, embracing the terminal stages of oocyte growth and post-fertilisation development up to implantation, is sensitive to parental nutrition. Deficiencies or excesses in a range of macro- and micronutrients during this period can lead to impairments in fertility, fetal development and long-term offspring health. Obesity and genotype-related differences in regional adiposity are associated with impaired liver function and insulin resistance, and contribute to fatty acid-mediated impairments in sperm viability and oocyte and embryo quality, all of which are associated with endoplasmic reticulum stress and compromised fertility. Disturbances to maternal protein metabolism can elevate ammonium concentrations in reproductive tissues and disturb embryo and fetal development. Associated with this are disturbances to one-carbon metabolism, which can lead to epigenetic modifications to DNA and associated proteins in offspring that are both insulin resistant and hypertensive. Many enzymes involved in epigenetic gene regulation use metabolic cosubstrates (e.g. acetyl CoA and S-adenosyl methionine) to modify DNA and associated proteins, and so act as ‘metabolic sensors’ providing a link between parental nutritional status and gene regulation. Separate to their genomic contribution, spermatozoa can also influence embryo development via direct interactions with the egg and by seminal plasma components that act on oviductal and uterine tissues.

Additional keywords: epigenetics, fetal programming, gametes, periconception, sperm.


References

Adamiak, S. J., Mackie, K., Watt, R. G., Webb, R., and Sinclair, K. D. (2005). Impact of nutrition on oocyte quality: cumulative effects of body composition and diet leading to hyperinsulinaemia in cattle. Biol. Reprod. 73, 918–926.
Impact of nutrition on oocyte quality: cumulative effects of body composition and diet leading to hyperinsulinaemia in cattle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtFGktb7L&md5=4a8245417d0f96ccbafe8e62953d21a1CAS | 15972884PubMed |

Adamiak, S. J., Powell, K., Rooke, J. A., Webb, R., and Sinclair, K. D. (2006). Body composition, dietary carbohydrates and fatty acids determine post-fertilisation development of bovine oocytes in vitro. Reproduction 131, 247–258.
Body composition, dietary carbohydrates and fatty acids determine post-fertilisation development of bovine oocytes in vitro.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XisFalsL8%3D&md5=501a8614b74f0d48507e2926aad5fbd1CAS | 16452718PubMed |

Agbaje, I. M., Rogers, D. A., McVicar, C. M., McClure, N., Atkinson, A. B., Mallidis, C., and Lewis, S. E. (2007). Insulin dependent diabetes mellitus: implications for male reproductive function. Hum. Reprod. 22, 1871–1877.
Insulin dependent diabetes mellitus: implications for male reproductive function.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXptFOrsLk%3D&md5=056fdf2eb56139f3a387bab5475f27f0CAS | 17478459PubMed |

Anckaert, E., Romero, S., Adriaenssens, T., and Smitz, J. (2010). Effects of low methyl donor levels in culture medium during mouse follicle culture on oocyte imprinting establishment. Biol. Reprod. 83, 377–386.
Effects of low methyl donor levels in culture medium during mouse follicle culture on oocyte imprinting establishment.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtVyrsrrF&md5=2abac492f269d71f894ec1e58ebf0049CAS | 20393167PubMed |

Andersen, H. S., Gambling, L., Holtrop, G., and McArdle, H. J. (2006). Maternal iron deficiency identifies critical windows for growth and cardiovascular development in the rat postimplantation embryo. J. Nutr. 136, 1171–1177.
| 1:CAS:528:DC%2BD28XktFagsrc%3D&md5=7b9acc89a86b9ae4c749a436f244e497CAS | 16614400PubMed |

Anderson, L. M., Riffle, L., Wilson, R., Travlos, G. S., Lubomirski, M. S., and Alvord, W. G. (2006). Preconceptional fasting of fathers alters serum glucose in offspring of mice. Nutrition 22, 327–331.
Preconceptional fasting of fathers alters serum glucose in offspring of mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xhslylur8%3D&md5=b65b581a85326ce8f93ad3854c0b0688CAS | 16500559PubMed |

Aoki, V. W., and Carrell, D. T. (2003). Human protamines and the developing spermatid: their structure, function, expression and relationship with male infertility. Asian J. Androl. 5, 315–324.
| 1:CAS:528:DC%2BD2cXhtFShtbw%3D&md5=58fe8100184d353c8a339b3c5f83dcd2CAS | 14695982PubMed |

Ashworth, C. J., Toma, L. M., and Hunter, M. G. (2009). Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability. Philos. Trans. R. Soc. Lond. B Biol. Sci. 364, 3351–3361.
Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability.Crossref | GoogleScholarGoogle Scholar | 19833647PubMed |

Aston, K. I., Punj, V., Liu, L., and Carrell, D. T. (2012). Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis. Fertil. Steril. 97, 285–292.
Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsVeru74%3D&md5=5b5fcd8020bcb34fa1bdaa2ab290a3baCAS | 22154369PubMed |

Baird, D. T., Collins, J., Egozcue, J., Evers, L. H., Gianaroli, L., Leridon, H., Sunde, A., Templeton, A., Van Steirteghem, A., Cohen, J., Crosignani, P. G., Devroey, P., Diedrich, K., Fauser, B. C., Fraser, L., Glasier, A., Liebaers, I., Mautone, G., Penney, G., and Tarlatzis, B. (2005). Fertility and ageing. ESHRE Capri Workshop Group. Hum. Reprod. Update 11, 261–276.
| 1:STN:280:DC%2BD2M3msVKhsA%3D%3D&md5=359b1420b68e11273c53fc40424af22cCAS | 15831503PubMed |

Bakos, H. W., Thompson, J. G., Feil, D., and Lane, M. (2008). Sperm DNA damage is associated with assisted reproductive technology pregnancy. Int. J. Androl. 31, 518–526.
Sperm DNA damage is associated with assisted reproductive technology pregnancy.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1aqsbbN&md5=687754ca51751bdac0a40e47f0526bb9CAS | 17822420PubMed |

Bakos, H. W., Mitchell, M., Setchell, B. P., and Lane, M. (2011). The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model. Int. J. Androl. 34, 402–410.
The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtlOlu7fP&md5=f1f5f2383eed9a627078e50c24a71444CAS | 20649934PubMed |

Barker, D. J. (2007). The origins of the developmental origins theory. J. Intern. Med. 261, 412–417.
The origins of the developmental origins theory.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2s3js1CqsA%3D%3D&md5=0a1e912b6124a6757d8ef28f716c7ee0CAS | 17444880PubMed |

Begum, G., Stevens, A., Smith, E. B., Connor, K., Challis, J. R., Bloomfield, F., and White, A. (2012). Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning. FASEB J. 26, 1694–1703.
Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XlsVCht70%3D&md5=7194e9d892ce58be2fb36a567d8d13c5CAS | 22223754PubMed |

Bener, A., Al-Ansari, A. A., Zirie, M., and Al-Hamaq, A. O. (2009). Is male fertility associated with type 2 diabetes mellitus? Int. Urol. Nephrol. 41, 777–784.
Is male fertility associated with type 2 diabetes mellitus?Crossref | GoogleScholarGoogle Scholar | 19381857PubMed |

Bergman, Y., and Cedar, H. (2013). DNA methylation dynamics in health and disease. Nat. Struct. Mol. Biol. 20, 274–281.
DNA methylation dynamics in health and disease.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXjsFOmu7g%3D&md5=5793cbcc4c048544c1c45dded7d18a09CAS | 23463312PubMed |

Bertolini, M., Mason, J. B., Beam, S. W., Carneiro, G. F., Sween, M. L., Kominek, D. J., Moyer, A. L., Famula, T. R., Sainz, R. D., and Anderson, G. B. (2002). Morphology and morphometry of in vivo- and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights. Theriogenology 58, 973–994.
Morphology and morphometry of in vivo- and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights.Crossref | GoogleScholarGoogle Scholar | 12212896PubMed |

Binder, N. K., Hannan, N. J., and Gardner, D. K. (2012). Paternal diet-induced obesity retards early mouse embryo development, mitochondrial activity and pregnancy health. PLoS One 7, e52304.
Paternal diet-induced obesity retards early mouse embryo development, mitochondrial activity and pregnancy health.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXmvFGhsA%3D%3D&md5=a7aafddc8f8c069a9ce003184928cf3fCAS | 23300638PubMed |

Bloomfield, F. H., Oliver, M. H., Hawkins, P., Holloway, A. C., Campbell, M., Gluckman, P. D., Harding, J. E., and Challis, J. R. (2004). Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic–pituitary–adrenal axis in late gestation. Endocrinology 145, 4278–4285.
Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic–pituitary–adrenal axis in late gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXnt1CitL8%3D&md5=8be873755e40bd55a0185a222d682ee9CAS | 15205376PubMed |

Borowczyk, E., Caton, J. S., Redmer, D. A., Bilski, J. J., Weigl, R. M., Vonnahme, K. A., Borowicz, P. P., Kirsch, J. D., Kraft, K. C., Reynolds, L. P., and Grazul-Bilska, A. T. (2006). Effects of plane of nutrition on in vitro fertilization and early embryonic development in sheep. J. Anim. Sci. 84, 1593–1599.
| 1:CAS:528:DC%2BD28XkvFOqsb8%3D&md5=b395b79e73f67e1ce4cbc173fa9baa23CAS | 16699117PubMed |

Bos-Mikich, A., Whittingham, D. G., and Jones, K. T. (1997). Meiotic and mitotic Ca2+ oscillations affect cell composition in resulting blastocysts. Dev. Biol. 182, 172–179.
Meiotic and mitotic Ca2+ oscillations affect cell composition in resulting blastocysts.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXht1Shur8%3D&md5=7fc5ac25ebdeb0fb0edb8f0b738b879cCAS | 9073459PubMed |

Breckenridge, D. G., Germain, M., Mathai, J. P., Nguyen, M., and Shore, G. C. (2003). Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22, 8608–8618.
Regulation of apoptosis by endoplasmic reticulum pathways.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXptFOmtbk%3D&md5=f81415309dcc84e8d1d14d510d708159CAS | 14634622PubMed |

Brykczynska, U., Hisano, M., Erkek, S., Ramos, L., Oakeley, E. J., Roloff, T. C., Beisel, C., Schubeler, D., Stadler, M. B., and Peters, A. H. (2010). Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat. Struct. Mol. Biol. 17, 679–687.
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXmtFalur8%3D&md5=2847bc46d764f26a12bfbdc9bd42f089CAS | 20473313PubMed |

Butler, W. R., Calaman, J. J., and Beam, S. W. (1996). Plasma and milk urea nitrogen in relation to pregnancy rate in lactating dairy cattle. J. Anim. Sci. 74, 858–865.
| 1:CAS:528:DyaK28XitlCiur0%3D&md5=54b29bcc9157c01ea02ce90e5514949bCAS | 8728008PubMed |

Carone, B. R., Fauquier, L., Habib, N., Shea, J. M., Hart, C. E., Li, R., Bock, C., Li, C., Gu, H., Zamore, P. D., Meissner, A., Weng, Z., Hofmann, H. A., Friedman, N., and Rando, O. J. (2010). Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 143, 1084–1096.
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhs1agtrbE&md5=5b2db822aa5b24c2c6efbc6322cbf348CAS | 21183072PubMed |

Carrell, D. T., Emery, B. R., and Hammoud, S. (2007). Altered protamine expression and diminished spermatogenesis: what is the link? Hum. Reprod. Update 13, 313–327.
Altered protamine expression and diminished spermatogenesis: what is the link?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXmtlCitr8%3D&md5=7bca9c905469491b716790ef11bb50d4CAS | 17208950PubMed |

Cedar, H., and Bergman, Y. (2009). Linking DNA methylation and histone modifcation: patterns and paradigms. Nat. Rev. Genet. 10, 295–304.
Linking DNA methylation and histone modifcation: patterns and paradigms.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXksF2rsL0%3D&md5=997496099ada57ed9e35bba740d34b6aCAS | 19308066PubMed |

Cerri, R. L., Juchem, S. O., Chebel, R. C., Rutigliano, H. M., Bruno, R. G., Galvao, K. N., Thatcher, W. W., and Santos, J. E. (2009). Effect of fat source differing in fatty acid profile on metabolic parameters, fertilization, and embryo quality in high-producing dairy cows. J. Dairy Sci. 92, 1520–1531.
Effect of fat source differing in fatty acid profile on metabolic parameters, fertilization, and embryo quality in high-producing dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXjvFamt78%3D&md5=c95fa45c7df55d8786362fd64cc811feCAS | 19307633PubMed |

Cetin, I., Berti, C., and Calabrese, S. (2010). Role of micronutrients in the periconceptional period. Hum. Reprod. Update 16, 80–95.
Role of micronutrients in the periconceptional period.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsFOht7rK&md5=0458efdedad2f18b541e3bd721f77ac5CAS | 19567449PubMed |

Chagas, L. M., Lucy, M. C., Back, P. J., Blanche, D., Lee, J. M., Gore, P. J., Sheahan, A. J., and Roche, J. R. (2009). Insulin resitance in divergent strains of Holstein–Friesian dairy cows offered fresh pasture and increasing amounts of concentrate in early lactation. J. Dairy Sci. 92, 216–222.
Insulin resitance in divergent strains of Holstein–Friesian dairy cows offered fresh pasture and increasing amounts of concentrate in early lactation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXlsVyjsQ%3D%3D&md5=bafc04329e6082f427f99346d7bb20d3CAS | 19109281PubMed |

Chavarro, J. E., Furtado, J., Toth, T. L., Ford, J., Keller, M., Campos, H., and Hauser, R. (2011). Trans-fatty acid levels in sperm are associated with sperm concentration among men from an infertility clinic. Fertil. Steril. 95, 1794–1797.
Trans-fatty acid levels in sperm are associated with sperm concentration among men from an infertility clinic.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXjs1Srtbk%3D&md5=176e56ab93e6403245eeccae65f6309bCAS | 21071027PubMed |

Chen, X., and Hess, S. (2008). Adipose proteome analysis: focus on mediators of insulin resitance. Expert Rev. Proteomics 5, 827–839.
Adipose proteome analysis: focus on mediators of insulin resitance.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhsFWjtLzI&md5=0acd3c1719e00ea668841afdef6e5e15CAS | 19086862PubMed |

Cheung, Y. B., Low, L., Osmond, C., Barker, D., and Karlberg, J. (2000). Fetal growth and early postnatal growth are related to blood pressure in adults. Hypertension 36, 795–800.
Fetal growth and early postnatal growth are related to blood pressure in adults.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3M%2FlvFKmtA%3D%3D&md5=919d9bd15799d911b8da5a9d9d8260bbCAS | 11082145PubMed |

Cho, C., Willis, W. D., Goulding, E. H., Jung-Ha, H., Choi, Y. C., Hecht, N. B., and Eddy, E. M. (2001). Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Nat. Genet. 28, 82–86.
Haploinsufficiency of protamine-1 or -2 causes infertility in mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXjt1ajsr8%3D&md5=9c09d87b96541a251ce1eef44e1e348fCAS | 11326282PubMed |

Coan, P. M., Vaughan, O. R., Sekita, Y., Finn, S. L., Burton, G. J., Constancia, M., and Fowden, A. L. (2010). Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice. J. Physiol. 588, 527–538.
Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhvV2js7o%3D&md5=51a9ade98b5a31a933a82ca65eb9426bCAS | 19948659PubMed |

Colaci, D. S., Afeiche, M., Gaskins, A. J., Wright, D. L., Toth, T. L., Tanrikut, C., Hauser, R., and Chavarro, J. E. (2012). Men’s body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization. Fertil. Steril. 98, 1193–1199.e1.
Men’s body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization.Crossref | GoogleScholarGoogle Scholar | 22884013PubMed |

Connor, K. L., Challis, J. R., van Zijl, P., Rumball, C. W., Alix, S., Jaquiery, A. L., Oliver, M. H., Harding, J. E., and Bloomfield, F. H. (2009). Do alterations in placental 11beta-hydroxysteroid dehydrogenase (11betaHSD) activities explain differences in fetal hypothalamic–pituitary–adrenal (HPA) function following periconceptional undernutrition or twinning in sheep? Reprod. Sci. 16, 1201–1212.
Do alterations in placental 11beta-hydroxysteroid dehydrogenase (11betaHSD) activities explain differences in fetal hypothalamic–pituitary–adrenal (HPA) function following periconceptional undernutrition or twinning in sheep?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsFKjtr7N&md5=0586240eed7d3eed19a5da0ee2ea859bCAS | 19767539PubMed |

Contri, A., De Amicis, I., Molinari, A., Faustini, M., Gramenzi, A., Robbe, D., and Carluccio, A. (2011). Effect of dietary antioxidant supplementation on fresh semen quality in stallion. Theriogenology 75, 1319–1326.
Effect of dietary antioxidant supplementation on fresh semen quality in stallion.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXjs12jt7w%3D&md5=bbd84e95e101a15eabe061b0de1ecc6fCAS | 21295825PubMed |

Cooper, W. N., Khulan, B., Owens, S., Elks, C. E., Seidel, V., Prentice, A. M., Belteki, G., Ong, K. K., Affara, N. A., Constancia, M., and Dunger, D. B. (2012). DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial. FASEB J. 26, 1782–1790.
DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XmvFSit7w%3D&md5=116d01b50f197f51a9af249132b712f0CAS | 22267336PubMed |

Dabelea, D., Pettitt, D. J., Hanson, R. L., Imperatore, G., Bennett, P. H., and Knowler, W. C. (1999). Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults. Diabetes Care 22, 944–950.
Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1MzgtVygtw%3D%3D&md5=b38a5c0da9278c655056470bde9a7929CAS | 10372247PubMed |

Dolinoy, D. C., Huang, D., and Jirtle, R. L. (2007). Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc. Natl Acad. Sci. USA 104, 13 056–13 061.
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXpt1GhsL8%3D&md5=a53f890b3bb9657ea986522ad343fc50CAS |

Eckert, J. J., Porter, R., Watkins, A. J., Burt, E., Brooks, S., Leese, H. J., Humpherson, P. G., Cameron, I. T., and Fleming, T. P. (2012). Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health. PLoS One 7, e52791.
Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXnsVKmtg%3D%3D&md5=7dd663e96c9b7fba5f1c3d8e681ff9b2CAS | 23300778PubMed |

Edwards, L. J., and McMillen, I. C. (2002a). Impact of maternal undernutrition during the periconceptional period, fetal number, and fetal sex on the development of the hypothalamo–pituitary adrenal axis in sheep during late gestation. Biol. Reprod. 66, 1562–1569.
Impact of maternal undernutrition during the periconceptional period, fetal number, and fetal sex on the development of the hypothalamo–pituitary adrenal axis in sheep during late gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XjtFWnsLY%3D&md5=6f1b6e5734096b73d05c8d5553b2c8d1CAS | 11967224PubMed |

Edwards, L. J., and McMillen, I. C. (2002b). Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283, R669–R679.
| 1:CAS:528:DC%2BD38XntFOns7Y%3D&md5=3f5750ce1b87e15264eae329b8cfbba7CAS | 12185002PubMed |

Elrod, C. C., and Butler, W. R. (1993). Reduction of fertility and alteration of uterine pH in heifers fed excess ruminally degradable protein. J. Anim. Sci. 71, 694–701.
| 1:STN:280:DyaK3s3hs1Gguw%3D%3D&md5=0eb586e3ab5047b835588e495b441c7dCAS | 8463156PubMed |

Esinler, I., Bozdag, G., and Yarali, H. (2008). Impact of isolated obesity on ICSI outcome. Reprod. Biomed. Online 17, 583–587.
Impact of isolated obesity on ICSI outcome.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1cnlvFygtw%3D%3D&md5=1214801bf776e7b9284e29ee597c8267CAS | 18854116PubMed |

Eskenazi, B., Kidd, S. A., Marks, A. R., Sloter, E., Block, G., and Wyrobek, A. J. (2005). Antioxidant intake is associated with semen quality in healthy men. Hum. Reprod. 20, 1006–1012.
Antioxidant intake is associated with semen quality in healthy men.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXis1yjtbc%3D&md5=e62a656757d584b1ac8d506a03ccbe39CAS | 15665024PubMed |

Eslamian, G., Amirjannati, N., Rashidkhani, B., Sadeghi, M. R., and Hekmatdoost, A. (2012). Intake of food groups and idiopathic asthenozoospermia: a case-control study. Hum. Reprod. 27, 3328–3336.
Intake of food groups and idiopathic asthenozoospermia: a case-control study.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsFKmu73F&md5=96fdacc4b34b7683e3236398354a065fCAS | 22940769PubMed |

Estienne, M. J., Harper, A. F., and Crawford, R. J. (2008). Dietary supplementation with a source of omega-3 fatty acids increases sperm number and the duration of ejaculation in boars. Theriogenology 70, 70–76.
Dietary supplementation with a source of omega-3 fatty acids increases sperm number and the duration of ejaculation in boars.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXmvVymurg%3D&md5=df47b8d700264ed1e6eed47be6f8e9faCAS | 18433852PubMed |

Fahey, J., Boland, M. P., and O’Callaghan, D. (2001). The effects of dietary urea on embryo development in superovulated donor ewes and on early embryo survival and development in recipient ewes. Anim. Sci. 72, 395–400.
| 1:CAS:528:DC%2BD3MXks1Krsb4%3D&md5=ede3f97cbfbd21808b3cf5bef144f55cCAS |

Ferguson, E. M., Ashworth, C. J., Edwards, S. A., Hawkins, N., Hepburn, N., and Hunter, M. G. (2003). Effect of different nutritional regimens before ovulation on plasma concentrations of metabolic and reproductive hormones and oocyte maturation in gilts. Reproduction 126, 61–71.
Effect of different nutritional regimens before ovulation on plasma concentrations of metabolic and reproductive hormones and oocyte maturation in gilts.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXlvFCnurw%3D&md5=e09f2c56c9262b557085db5ffb617e53CAS | 12814348PubMed |

Ferguson, E. M., Slevin, J., Hunter, M. G., Edwards, S. A., and Ashworth, C. J. (2007). Beneficial effects of a high fibre diet on oocyte maturity and embryo survival in gilts. Reproduction 133, 433–439.
Beneficial effects of a high fibre diet on oocyte maturity and embryo survival in gilts.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjvVOjt78%3D&md5=6a6fcf0987e7570107cc301c6b782488CAS | 17307911PubMed |

Fernandez, C. D., Bellentani, F. F., Fernandes, G. S., Perobelli, J. E., Favareto, A. P., Nascimento, A. F., Cicogna, A. C., and Kempinas, W. D. (2011). Diet-induced obesity in rats leads to a decrease in sperm motility. Reprod. Biol. Endocrinol. 9, 32.
Diet-induced obesity in rats leads to a decrease in sperm motility.Crossref | GoogleScholarGoogle Scholar | 21396114PubMed |

Ferreira, F. A., Gomez, R. G., Joaquim, D. C., Watanabe, Y. F., de Castro e Paula, L. A., Binelli, M., and Rodrigues, P. H. (2011). Short-term urea feeding decreases in vitro hatching of bovine blastocysts. Theriogenology 76, 312–319.e1.
Short-term urea feeding decreases in vitro hatching of bovine blastocysts.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXnsFWitbc%3D&md5=c7499f5e5d536cb946c779dc28267c4eCAS | 21496898PubMed |

Fleming, T. P., Lucas, E. S., Watkins, A. J., and Eckert, J. J. (2012). Adaptive responses of the embryo to maternal diet and consequences for post-implantation development. Reprod. Fertil. Dev. 24, 35–44.
Adaptive responses of the embryo to maternal diet and consequences for post-implantation development.Crossref | GoogleScholarGoogle Scholar |

Forsén, T., Eriksson, J. G., Tuomilehto, J., Teramo, K., Osmond, C., and Barker, D. J. (1997). Mother’s weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ 315, 837–840.
Mother’s weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study.Crossref | GoogleScholarGoogle Scholar | 9353502PubMed |

Fouladi-Nashta, A. A., Gutierrez, C. G., Gong, J. G., Garnsworthy, P. C., and Webb, R. (2007). Impact of dietary fatty acids on oocyte quality and development in lactating dairy cows. Biol. Reprod. 77, 9–17.
Impact of dietary fatty acids on oocyte quality and development in lactating dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXntV2gsb0%3D&md5=6b0bcdc23d6aff9e9530f4af30daee6fCAS | 17344470PubMed |

Fullston, T., Palmer, N. O., Owens, J. A., Mitchell, M., Bakos, H. W., and Lane, M. (2012). Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice. Hum. Reprod. 27, 1391–1400.
Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC38vjvFGhsQ%3D%3D&md5=5ec6f98b2da12835bbf227339520e452CAS | 22357767PubMed |

Gallagher, D., Kelley, D. E., Yim, J. E., Spence, N., Albu, J., Boxt, L., Pi-Sunyer, F. X., and Heshka, S. (2009). Adipose tissue distribution is different in type 2 diabetes. Am. J. Clin. Nutr. 89, 807–814.
Adipose tissue distribution is different in type 2 diabetes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXjtFGltb8%3D&md5=6979e86212e4b7da7e2c974221f19b14CAS | 19158213PubMed |

Gardner, D. S., Pearce, S., Dandrea, J., Walker, R., Ramsay, M. M., Stephenson, T., and Symonds, M. E. (2004). Peri-implantation undernutrition programs blunted angiotensin II evoked baroreflex responses in young adult sheep. Hypertension 43, 1290–1296.
Peri-implantation undernutrition programs blunted angiotensin II evoked baroreflex responses in young adult sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXktFSks7o%3D&md5=3011d62e9156d2a7d33ad599e9dce036CAS | 15078864PubMed |

Gardner, D. K., Hamilston, R., McCallie, B., Schoolcraft, W. B., and Katz-Jaffe, M. G. (2013). Human and mouse embryonic development, metabolism and gene expression are altered by an ammonium gradient in vitro. Reproduction 146, 49–61.
Human and mouse embryonic development, metabolism and gene expression are altered by an ammonium gradient in vitro.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhtFejsLbL&md5=c844a99008c1ccb9769195aa681880eaCAS | 23613618PubMed |

Gaskins, A. J., Colaci, D. S., Mendiola, J., Swan, S. H., and Chavarro, J. E. (2012). Dietary patterns and semen quality in young men. Hum. Reprod. 27, 2899–2907.
Dietary patterns and semen quality in young men.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtlymsbfF&md5=cbb69824d4b5e631b3c3dfdde3dd0cccCAS | 22888168PubMed |

Gath, V. P., Crowe, M. A., O’Callaghan, D., Boland, M. P., Duffy, P., Lonergan, P., and Mulligan, F. J. (2012). Effects of diet type on establishment of pregnancy and embryo development in beef heifers. Anim. Reprod. Sci. 133, 139–145.
Effects of diet type on establishment of pregnancy and embryo development in beef heifers.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC38fhvVeqtA%3D%3D&md5=7aa116d20fe67bd30e06989a5c583b9cCAS | 22818782PubMed |

Gauthier, D., and Berbigier, P. (1982). The influence of nutritional levels and shade structure on testicular growth and hourly variations of plasma-LH and testosterone levels in young creole bulls in a tropical environment. Reprod. Nutr. Dev. 22, 793–801.
The influence of nutritional levels and shade structure on testicular growth and hourly variations of plasma-LH and testosterone levels in young creole bulls in a tropical environment.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3sXpvFI%3D&md5=a2155cb08a5ac88bab4e517f5955e36cCAS | 7156502PubMed |

Gbore, F. A. (2009). Reproductive organ weights and semen quality of pubertal boars fed dietary fumonisin B1. Animal 3, 1133–1137.
Reproductive organ weights and semen quality of pubertal boars fed dietary fumonisin B1.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXpvFejur8%3D&md5=ab2f54aea51c5752fff52922d04b6af5CAS | 22444843PubMed |

Ghanayem, B. I., Bai, R., Kissling, G. E., Travlos, G., and Hoffler, U. (2010). Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol. Reprod. 82, 96–104.
Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhs1WgsrrK&md5=e1f407654f03b1b6730895fe85ea3716CAS | 19696015PubMed |

Gholami, H., Chamani, M., Towhidi, A., and Fazeli, M. H. (2010). Effect of feeding a docosahexaenoic acid-enriched nutriceutical on the quality of fresh and frozen–thawed semen in Holstein bulls. Theriogenology 74, 1548–1558.
Effect of feeding a docosahexaenoic acid-enriched nutriceutical on the quality of fresh and frozen–thawed semen in Holstein bulls.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtlKhsLnF&md5=8b3e2975d077b6bd03ccebe5011ea6faCAS | 20708237PubMed |

Gonzalez-Añover, P., Encinas, T., Torres-Rovira, L., Pallares, P., Muñoz-Frutos, J., Gomez-Izquierdo, E., Sanchez-Sanchez, R., and Gonzalez-Bulnes, A. (2011). Ovulation rate, embryo mortality and intrauterine growth retardation in obese swine with gene polymorphisms for leptin and melanocortin receptors. Theriogenology 75, 34–41.
Ovulation rate, embryo mortality and intrauterine growth retardation in obese swine with gene polymorphisms for leptin and melanocortin receptors.Crossref | GoogleScholarGoogle Scholar | 20833418PubMed |

Gopal, K., Kumar, K., Nandini, R., Jahan, P., and Kumar, M. J. (2010). High fat diet containing cholesterol induce aortic aneurysm through recruitment and proliferation of circulating agranulocytes in apoE knock out mice model. J. Thromb. Thrombolysis 30, 154–163.
High fat diet containing cholesterol induce aortic aneurysm through recruitment and proliferation of circulating agranulocytes in apoE knock out mice model.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXpt12mtrY%3D&md5=4db378f733cc22f57849f03b6f9e4e49CAS | 20177736PubMed |

Grazul-Bilska, A. T., Borowczyk, E., Bilski, J. J., Reynolds, L. P., Redmer, D. A., Caton, J. S., and Vonnahme, K. A. (2012). Overfeeding and underfeeding have detrimental effects on oocyte quality measured by in vitro fertilization and early embryonic development in sheep. Domest. Anim. Endocrinol. 43, 289–298.
Overfeeding and underfeeding have detrimental effects on oocyte quality measured by in vitro fertilization and early embryonic development in sheep.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC38nnvVSksA%3D%3D&md5=42037f2bb6ab6174550dde5811254c87CAS | 22652013PubMed |

Hammiche, F., Laven, J. S., Twigt, J. M., Boellaard, W. P., Steegers, E. A., and Steegers-Theunissen, R. P. (2012). Body mass index and central adiposity are associated with sperm quality in men of subfertile couples. Hum. Reprod. 27, 2365–2372.
Body mass index and central adiposity are associated with sperm quality in men of subfertile couples.Crossref | GoogleScholarGoogle Scholar | 22693175PubMed |

Hammoud, A. O., Gibson, M., Stanford, J., White, G., Carrell, D. T., and Peterson, M. (2009). In vitro fertilization availability and utilization in the United States: a study of demographic, social, and economic factors. Fertil. Steril. 91, 1630–1635.
In vitro fertilization availability and utilization in the United States: a study of demographic, social, and economic factors.Crossref | GoogleScholarGoogle Scholar | 18539275PubMed |

Hammoud, S. S., Nix, D. A., Hammoud, A. O., Gibson, M., Cairns, B. R., and Carrell, D. T. (2011). Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men. Hum. Reprod. 26, 2558–2569.
Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtVynsrzI&md5=7e5e78ea21f65689844ba2faebf8e565CAS | 21685136PubMed |

Hedley, A. A., Ogden, C. L., Johnson, C. L., Carroll, M. D., Curtin, L. R., and Flegal, K. M. (2004). Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA 291, 2847–2850.
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXkvFKnsbw%3D&md5=8a512651f4a1ef829d00e0e4d075721fCAS | 15199035PubMed |

Hill, M. J., Hong, S., and Frattarelli, J. L. (2011). Body mass index impacts in vitro fertilization stimulation. ISRN Obstet. Gynecol. 2011, Article ID 929251.
Body mass index impacts in vitro fertilization stimulation.Crossref | GoogleScholarGoogle Scholar |

Hostens, M., Fievez, V., Leroy, J. L. M. R., Van Ranst, J., Vlaeminck, B., and Opsomer, G. (2012). The fatty acid profile of subcutaneous and abdominal fat in dairy cows with left displacement of the abomasum. J. Dairy Sci. 95, 3756–3765.
The fatty acid profile of subcutaneous and abdominal fat in dairy cows with left displacement of the abomasum.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XoslKjtLw%3D&md5=605d184f57922167061920273b9a9156CAS | 22720932PubMed |

Igosheva, N., Abramov, A. Y., Poston, L., Eckert, J. J., Fleming, T. P., Duchen, M. R., and McConnell, J. (2010). Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One 5, e10074.
Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes.Crossref | GoogleScholarGoogle Scholar | 20404917PubMed |

Jaquiery, A. L., Oliver, M. H., Bloomfield, F. H., Connor, K. L., Challis, J. R., and Harding, J. E. (2006). Fetal exposure to excess glucocorticoid is unlikely to explain the effects of periconceptional undernutrition in sheep. J. Physiol. 572, 109–118.
| 1:CAS:528:DC%2BD28Xkt1Ghtbw%3D&md5=479676cc55756b1ad08992f8fbfa5421CAS | 16469778PubMed |

Jungheim, E. S., Schoeller, E. L., Marquard, K. L., Louden, E. D., Schaffer, J. E., and Moley, K. H. (2010). Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology 151, 4039–4046.
Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXht1Oju7rN&md5=2f52321b295b6f36e0ded14a73dd8cf1CAS | 20573727PubMed |

Kaelin, W. G., and McKnight, S. L. (2013). Influence of metabolism on epigenetics and disease. Cell 153, 56–69.
Influence of metabolism on epigenetics and disease.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXltVemtrk%3D&md5=7afe3471fb77532bd4618ba434642b22CAS | 23540690PubMed |

Kakar, M. A., Maddocks, S., Lorimer, M. F., Kleemann, D. O., Rudiger, S. R., Hartwich, K. M., and Walker, S. K. (2005). The effect of peri-conception nutrition on embryo quality in the superovulated ewe. Theriogenology 64, 1090–1103.
The effect of peri-conception nutrition on embryo quality in the superovulated ewe.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2MvlvF2muw%3D%3D&md5=473d375f29a13bf854b9ca1563d1cce5CAS | 16125553PubMed |

Kelly, T., Yang, W., Chen, C. S., Reynolds, K., and He, J. (2008). Global burden of obesity in 2005 and projections to 2030. Int. J. Obes. 32, 1431–1437.
Global burden of obesity in 2005 and projections to 2030.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1cngsVamtQ%3D%3D&md5=9d2dea1024ca40bdbcbcdb24de273ff5CAS |

Kenny, D. A., Humpherson, P. G., Leese, H. J., Morris, D. G., Tomos, A. D., Diskin, D. G., and Sreenan, J. M. (2002). Effect of elevated systemic concentrations of ammonia and urea on the metabolite and ionic composition of oviductal fluid in cattle. Biol. Reprod. 66, 1797–1804.
Effect of elevated systemic concentrations of ammonia and urea on the metabolite and ionic composition of oviductal fluid in cattle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XjvFegu7Y%3D&md5=f4bb943c52bc599760befdebf8883221CAS | 12021065PubMed |

Kim, S. T., and Moley, K. H. (2008). Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression. Reproduction 136, 313–322.
Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1GmtLzF&md5=57c7ed86b0f3cd7123579e0312acdbc9CAS | 18558660PubMed |

Knott, J. G., Kurokawa, M., Fissore, R. A., Schultz, R. M., and Williams, C. J. (2005). Transgenic RNA interference reveals role for mouse sperm phospholipase Cζ in triggering Ca2+ oscillations during fertilization. Biol. Reprod. 72, 992–996.
Transgenic RNA interference reveals role for mouse sperm phospholipase Cζ in triggering Ca2+ oscillations during fertilization.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXis12hsLc%3D&md5=0cb410f383285e0299ed702d4d38b622CAS | 15601914PubMed |

Kort, H. I., Massey, J. B., Elsner, C. W., Mitchell-Leef, D., Shapiro, D. B., Witt, M. A., and Roudebush, W. E. (2006). Impact of body mass index values on sperm quantity and quality. J. Androl. 27, 450–452.
Impact of body mass index values on sperm quantity and quality.Crossref | GoogleScholarGoogle Scholar | 16339454PubMed |

Kulie, T., Slattengren, A., Redmer, J., Counts, H., Eglash, A., and Schrager, S. (2011). Obesity and women’s health: an evidence-based review. J. Am. Board Fam. Med. 24, 75–85.
Obesity and women’s health: an evidence-based review.Crossref | GoogleScholarGoogle Scholar | 21209347PubMed |

Kumar, N., Verma, R. P., Singh, L. P., Varshney, V. P., and Dass, R. S. (2006). Effect of different levels and sources of zinc supplementation on quantitative and qualitative semen attributes and serum testosterone level in crossbred cattle (Bos indicus × Bos taurus) bulls. Reprod. Nutr. Dev. 46, 663–675.
Effect of different levels and sources of zinc supplementation on quantitative and qualitative semen attributes and serum testosterone level in crossbred cattle (Bos indicus × Bos taurus) bulls.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXht1Sjsb0%3D&md5=0854bfa7714a0c86994dcf19c60c4ffbCAS | 17169313PubMed |

Kumarasamy, V., Mitchell, M. D., Bloomfield, F. H., Oliver, M. H., Campbell, M. E., Challis, J. R., and Harding, J. E. (2005). Effects of periconceptional undernutrition on the initiation of parturition in sheep. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R67–R72.
Effects of periconceptional undernutrition on the initiation of parturition in sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtVCqur0%3D&md5=0e926ed02a0bd10beaadb5637d9a5db6CAS | 15331382PubMed |

Kwong, W. Y., Wild, A. E., Roberts, P., Willis, A. C., and Fleming, T. P. (2000). Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development 127, 4195–4202.
| 1:CAS:528:DC%2BD3cXotVWisbw%3D&md5=39d10cbbae06831352af239916382c15CAS | 10976051PubMed |

Kwong, W. Y., Miller, D. J., Ursell, E., Wild, A. E., Wilkins, A. P., Osmond, C., Anthony, F. W., and Fleming, T. P. (2006). Imprinted gene expression in the rat embryo–fetal axis is altered in response to periconceptional maternal low protein diet. Reproduction 132, 265–277.
Imprinted gene expression in the rat embryo–fetal axis is altered in response to periconceptional maternal low protein diet.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xpt1Wjsrc%3D&md5=290d476d6e594a3a036e56ce37973cefCAS | 16885535PubMed |

Kwong, W. Y., Adamiak, S. J., Gwynn, A., Singh, R., and Sinclair, K. D. (2010). Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo. Reproduction 139, 705–715.
Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXltFajtrs%3D&md5=2ad8bd3a7fc358d4c31b5838ef83d6a4CAS | 20083604PubMed |

La Vignera, S., Condorelli, R. A., Vicari, E., D’Agata, R., Salemi, M., and Calogero, A. E. (2012). High levels of lipid peroxidation in semen of diabetic patients. Andrologia 44, 565–570.
High levels of lipid peroxidation in semen of diabetic patients.Crossref | GoogleScholarGoogle Scholar | 21919944PubMed |

Laanpere, M., Altmae, S., Stavreus-Evers, A., Nilsson, T. K., Yngve, A., and Salumets, A. (2010). Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability. Nutr. Rev. 68, 99–113.
Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability.Crossref | GoogleScholarGoogle Scholar | 20137055PubMed |

Lane, M., and Gardner, D. K. (2003). Ammonium induces aberrant blastocyst differentiation, metabolism, pH regulation, gene expression and subsequently alters fetal development in the mouse. Biol. Reprod. 69, 1109–1117.
Ammonium induces aberrant blastocyst differentiation, metabolism, pH regulation, gene expression and subsequently alters fetal development in the mouse.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXnsV2nsr8%3D&md5=c3fe97f4803900194393a252aeb6c33bCAS | 12773416PubMed |

Leroy, J. L. M. R., Vanholder, T., Mateusen, B., Christophe, A., Opsomer, G., de Kruif, G., Genicot, G., and Van Soom, A. (2005). Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. Reproduction 130, 485–495.
Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtFent7rJ&md5=cd82fd88938bb4bfbef1f4cb6ee5e020CAS |

López, A., Rijsselaere, T., Van Soom, A., Leroy, J. L., De Clercq, J. B., Bols, P. E., and Maes, D. (2010). Effect of organic selenium in the diet on sperm quality of boars. Reprod. Domest. Anim. 45, e297–e305.
Effect of organic selenium in the diet on sperm quality of boars.Crossref | GoogleScholarGoogle Scholar | 20015118PubMed |

MacLaughlin, S. M., Walker, S. K., Kleemann, D. O., Tosh, D. N., and McMillen, I. C. (2010). Periconceptional undernutrition and being a twin each alter kidney development in the sheep fetus during early gestation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R692–R699.
Periconceptional undernutrition and being a twin each alter kidney development in the sheep fetus during early gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXjsFGntro%3D&md5=3ae18cd6b904214f9001622688b4961cCAS | 20053964PubMed |

Malhotra, J. D., and Kaufman, R. J. (2007). Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox Signal. 9, 2277–2294.
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXht1GrsLzL&md5=c5bb3fd2c9319d97f3212b4cf1523b04CAS | 17979528PubMed |

Maloney, C. A., Hay, S. M., Young, L. E., Sinclair, K. D., and Rees, W. D. (2011). A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring. J. Nutr. 141, 95–100.
A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring.Crossref | GoogleScholarGoogle Scholar | 21106931PubMed |

Marquard, K. L., Stephens, S. M., Jungheim, E. S., Ratts, V. S., Odem, R. R., Lanzendorf, S., and Moley, K. H. (2011). Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil. Steril. 95, 2146–2149.
Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles.Crossref | GoogleScholarGoogle Scholar | 21071018PubMed |

Martin, G. B., Tjondronegoro, S., and Blackberry, M. A. (1994). Effects of nutrition on testicular size and the concentrations of gonadotrophins, testosterone and inhibin in plasma of mature male sheep. J. Reprod. Fertil. 101, 121–128.
Effects of nutrition on testicular size and the concentrations of gonadotrophins, testosterone and inhibin in plasma of mature male sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXkvVWks7s%3D&md5=2a72819dd1a84b626c4daf6abc7041e0CAS | 8064670PubMed |

Martin, G. B., Blache, D., Miller, D. W., and Vercoe, P. E. (2010). Interactions between nutrition and reproduction in the management of the mature male ruminant. Animal 4, 1214–1226.
Interactions between nutrition and reproduction in the management of the mature male ruminant.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC38vptFyrug%3D%3D&md5=be9fa5c88bb68e55ecd0e0c704b465d0CAS | 22444618PubMed |

McEvoy, T. G., Robinson, J. J., Aitken, R. P., Findlay, P. A., and Robertson, I. S. (1997). Dietary excesses of urea influence the viability and metabolism of preimplantation sheep embryos and may affect fetal growth among survivors. Anim. Reprod. Sci. 47, 71–90.
Dietary excesses of urea influence the viability and metabolism of preimplantation sheep embryos and may affect fetal growth among survivors.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXksVSrt7g%3D&md5=cea5b794b5b3c40f24ce06c9bdbc5273CAS | 9233507PubMed |

McMillen, I. C., MacLaughlin, S. M., Muhlhausler, B. S., Gentili, S., Duffield, J. L., and Morrison, J. L. (2008). Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition. Basic Clin. Pharmacol. Toxicol. 102, 82–89.
Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhvF2gsrg%3D&md5=f50e3aac875dae4e681250b23817ee43CAS | 18226059PubMed |

Metwally, M., Cutting, R., Tipton, A., Skull, J., Ledger, W. L., and Li, T. C. (2007). Effect of increased body mass index on oocyte and embryo quality in IVF patients. Reprod. Biomed. Online 15, 532–538.
Effect of increased body mass index on oocyte and embryo quality in IVF patients.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2sjgslWruw%3D%3D&md5=cf4fcc07ad06257b4db41fe4fde9b813CAS | 18044034PubMed |

Meza-Herrera, C. A., Ross, T. T., Hallford, D. M., Hawkins, D. E., and Gonzalez-Bulnes, A. (2010). High periconceptional protein intake modifies uterine and embryonic relationships increasing early pregnancy losses and embryo growth retardation in sheep. Reprod Domest. Anim. 45, 723–728.
| 1:STN:280:DC%2BC3cnpsFSrtw%3D%3D&md5=009f8e896cfd988971ebad8ed619b145CAS | 19220796PubMed |

Micke, G. C., Sullivan, T. M., Gatford, K. L., Owens, J. A., and Perry, V. E. (2010). Nutrient intake in the bovine during early and mid-gestation causes sex-specific changes in progeny plasma IGF-I, liveweight, height and carcass traits. Anim. Reprod. Sci. 121, 208–217.
Nutrient intake in the bovine during early and mid-gestation causes sex-specific changes in progeny plasma IGF-I, liveweight, height and carcass traits.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtV2hsrrE&md5=22655595be0da51092d48072d7f1334eCAS | 20591585PubMed |

Micke, G. C., Sullivan, T. M., McMillen, I. C., Gentili, S., and Perry, V. E. (2011). Heifer nutrient intake during early- and mid-gestation programs adult offspring adiposity and mRNA expression of growth-related genes in adipose depots. Reproduction 141, 697–706.
Heifer nutrient intake during early- and mid-gestation programs adult offspring adiposity and mRNA expression of growth-related genes in adipose depots.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXmvFCis78%3D&md5=26a1e07a2f52cf87955f15e293bc5cf6CAS | 21310814PubMed |

Minge, C. E., Bennett, B. D., Norman, R. J., and Robker, R. L. (2008). Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality. Endocrinology 149, 2646–2656.
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1Gmsb%2FO&md5=d7861345514b20d67f213d9d25f07ef5CAS | 18276752PubMed |

Mitchell, M., Schulz, S. L., Armstrong, D. T., and Lane, M. (2009). Metabolic and mitochondrial dysfunction in early mouse embryos following maternal dietary protein intervention. Biol. Reprod. 80, 622–630.
Metabolic and mitochondrial dysfunction in early mouse embryos following maternal dietary protein intervention.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXjvVSktLo%3D&md5=7bb622d7c049d06e9de1572394576d1eCAS | 19129514PubMed |

Mitchell, M., Bakos, H. W., and Lane, M. (2011). Paternal diet-induced obesity impairs embryo development and implantation in the mouse. Fertil. Steril. 95, 1349–1353.
Paternal diet-induced obesity impairs embryo development and implantation in the mouse.Crossref | GoogleScholarGoogle Scholar | 21047633PubMed |

Ng, S. F., Lin, R. C., Laybutt, D. R., Barres, R., Owens, J. A., and Morris, M. J. (2010). Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring. Nature 467, 963–966.
Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtlWlsr%2FF&md5=e7e4c966b752e85ea6728ffe413eccc9CAS | 20962845PubMed |

Nicholas, L. M., Rattanatray, L., Maclaughlin, S. M., Ozanne, S. E., Kleemann, D. O., Walker, S. K., Morrison, J. L., Zhang, S., Muhlhausler, B. S., Martin-Gronert, M. S., and McMillen, I. C. (2013). Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring. FASEB J. 27, 3786–3796.
| 1:CAS:528:DC%2BC3sXhsVaitLrF&md5=337ea1799880e1cc1409d5f39364f830CAS | 23729590PubMed |

Nolan, R., O’Callaghan, D., Duby, R. T., Lonergan, P., and Boland, M. P. (1998). The influence of short-term nutrient changes on follicle growth and embryo production following superovulation in beef heifers. Theriogenology 50, 1263–1274.
The influence of short-term nutrient changes on follicle growth and embryo production following superovulation in beef heifers.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3c7pvVKitw%3D%3D&md5=c51a92dd0ebff4854791d0e359915dc6CAS | 10734440PubMed |

Oliver, M. H., Hawkins, P., and Harding, J. E. (2005). Periconceptional undernutrition alters growth trajectory and metabolic and endocrine responses to fasting in late-gestation fetal sheep. Pediatr. Res. 57, 591–598.
Periconceptional undernutrition alters growth trajectory and metabolic and endocrine responses to fasting in late-gestation fetal sheep.Crossref | GoogleScholarGoogle Scholar | 15695605PubMed |

Ozil, J. P., and Huneau, D. (2001). Activation of rabbit oocytes: the impact of the Ca2+ signal regime on development. Development 128, 917–928.
| 1:CAS:528:DC%2BD3MXislaqu74%3D&md5=21e2f89fa0cd210f68a3101be42c7749CAS | 11222146PubMed |

Palmer, N. O., Fullston, T., Mitchell, M., Setchell, B. P., and Lane, M. (2011). SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. Reprod. Fertil. Dev. 23, 929–939.
SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtVOrtb7J&md5=c372fd7061a495cf212e9ad8873b406dCAS | 21871212PubMed |

Parker, G. V., and Thwaites, C. J. (1972). The effects of undernutrition on libido and semen quality in adult merino rams. Aust. J. Agric. Res. 23, 109–115.
The effects of undernutrition on libido and semen quality in adult merino rams.Crossref | GoogleScholarGoogle Scholar |

Pembrey, M. E., Bygren, L. O., Kaati, G., Edvinsson, S., Northstone, K., Sjostrom, M., and Golding, J. (2006). Sex-specific, male-line transgenerational responses in humans. Eur. J. Hum. Genet. 14, 159–166.
Sex-specific, male-line transgenerational responses in humans.Crossref | GoogleScholarGoogle Scholar | 16391557PubMed |

Pérez-Crespo, M., Moreira, P., Pintado, B., and Gutiérrez-Adán, A. (2008). Factors from damaged sperm affect its DNA integrity and its ability to promote embryo implantation in mice. J. Androl. 29, 47–54.
Factors from damaged sperm affect its DNA integrity and its ability to promote embryo implantation in mice.Crossref | GoogleScholarGoogle Scholar | 17673434PubMed |

Perry, V. E., Norman, S. T., Owen, J. A., Daniel, R. C., and Phillips, N. (1999). Low dietary protein during early pregnancy alters bovine placental development. Anim. Reprod. Sci. 55, 13–21.
Low dietary protein during early pregnancy alters bovine placental development.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXhtFeitrY%3D&md5=891488c511909a16f253c8c852dc30f3CAS | 10099675PubMed |

Picone, O., Laigre, P., Fortun-Lamothe, L., Archilla, C., Peynot, N., Ponter, A. A., Berthelot, V., Cordier, A. G., Duranthon, V., and Chavatte-Palmer, P. (2011). Hyperlipidic hypercholesterolemic diet in prepubertal rabbits affects gene expression in the embryo, restricts fetal growth and increases offspring susceptibility to obesity. Theriogenology 75, 287–299.
Hyperlipidic hypercholesterolemic diet in prepubertal rabbits affects gene expression in the embryo, restricts fetal growth and increases offspring susceptibility to obesity.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhsF2isbnK&md5=4277af21c30306d54f6867b8d76fb3b0CAS | 21040967PubMed |

Pisani, L. F., Antonini, S., Pocar, P., Ferrari, S., Brevini, T. A., Rhind, S. M., and Gandolfi, F. (2008). Effects of pre-mating nutrition on mRNA levels of developmentally relevant genes in sheep oocytes and granulosa cells. Reproduction 136, 303–312.
Effects of pre-mating nutrition on mRNA levels of developmentally relevant genes in sheep oocytes and granulosa cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1GmtLzE&md5=239a695736db98f1bf7874db42741d58CAS | 18515315PubMed |

Powell, K., Rooke, J. A., McEvoy, T. G., Ashworth, C. J., Robinson, J. J., Wilmut, I., Young, L. E., and Sinclair, K. D. (2006). Zygote donor nitrogen metabolism and in vitro embryo culture perturbs in utero development and IGF2R expression in ovine fetal tissues. Theriogenology 66, 1901–1912.
Zygote donor nitrogen metabolism and in vitro embryo culture perturbs in utero development and IGF2R expression in ovine fetal tissues.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtVGjtLzJ&md5=fb83707a0fd9159759345e8f69f55b76CAS | 16777210PubMed |

Rato, L., Alves, M. G., Dias, T. R., Lopes, G., Cavaco, J. E., Socorro, S., and Oliveira, P. F. (2013). High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters. Andrology 1, 495–504.
High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXmt1Kqtrc%3D&md5=bf365404ef0789a019751eff72df3040CAS | 23495257PubMed |

Ravelli, A. C., van der Meulen, J. H., Michels, R. P., Osmond, C., Barker, D. J., Hales, C. N., and Bleker, O. P. (1998). Glucose tolerance in adults after prenatal exposure to famine. Lancet 351, 173–177.
Glucose tolerance in adults after prenatal exposure to famine.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1c7htFGhtw%3D%3D&md5=5f61dcbecc0a9fee70c85227dae48428CAS | 9449872PubMed |

Ravelli, A. C., van Der Meulen, J. H., Osmond, C., Barker, D. J., and Bleker, O. P. (1999). Obesity at the age of 50 y in men and women exposed to famine prenatally. Am. J. Clin. Nutr. 70, 811–816.
| 1:CAS:528:DyaK1MXntFCgtbk%3D&md5=bee76304a5473d45bee14aeabc5ddec2CAS | 10539740PubMed |

Rich-Edwards, J. W., Stampfer, M. J., Manson, J. E., Rosner, B., Hankinson, S. E., Colditz, G. A., Willett, W. C., and Hennekens, C. H. (1997). Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. BMJ 315, 396–400.
Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2svitlKlsw%3D%3D&md5=af8a4842306631a26ea26e34efbdeb6bCAS | 9277603PubMed |

Robinson, J. J., Ashworth, C. J., Rooke, J. A., Mitchell, L. M., and McEvoy, T. G. (2006). Nutrition and fertility in ruminant livestock. Anim. Feed Sci. Technol. 126, 259–276.
Nutrition and fertility in ruminant livestock.Crossref | GoogleScholarGoogle Scholar |

Robker, R. L., Akison, L. K., Bennett, B. D., Thrupp, P. N., Chura, L. R., Russell, D. L., Lane, M., and Norman, R. J. (2009). Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J. Clin. Endocrinol. Metab. 94, 1533–1540.
Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXlvVCqtrw%3D&md5=64e74dabbab655fb7b2c30636a9a8bb1CAS | 19223519PubMed |

Ronnenberg, A. G., Wood, R. J., Wang, X., Xing, H., Chen, C., Chen, D., Guang, W., Huang, A., Wang, L., and Xu, X. (2004). Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women. J. Nutr. 134, 2586–2591.
| 1:CAS:528:DC%2BD2cXosV2jtL0%3D&md5=b430da8c6455114b92dae19fe5b738e4CAS | 15465752PubMed |

Rooke, J. A., Ewen, M., Mackie, K., Staines, M. E., McEvoy, T. G., and Sinclair, K. D. (2004). Effect of ammonium chloride on the growth and metabolism of bovine ovarian granulosa cells and the development of ovine oocytes matured in the presence of bovine granulosa cells previously exposed to ammonium chloride. Anim. Reprod. Sci. 84, 53–71.
Effect of ammonium chloride on the growth and metabolism of bovine ovarian granulosa cells and the development of ovine oocytes matured in the presence of bovine granulosa cells previously exposed to ammonium chloride.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXmsVGjsrs%3D&md5=4e4b7163246a8ab1f1365f37df9c637dCAS | 15302387PubMed |

Rosario, J. F., Gomez, M. P., and Anbu, P. (2008). Does the maternal micronutrient deficiency (copper or zinc or vitamin E) modulate the expression of placental 11 beta hydroxysteroid dehydrogenase-2 per se predispose offspring to insulin resistance and hypertension in later life? Indian J. Physiol. Pharmacol. 52, 355–365.
| 1:CAS:528:DC%2BD1MXlsFOitLw%3D&md5=82f527d659e8e2869bbda0b722e9e6a5CAS | 19585752PubMed |

Roseboom, T. J., van der Meulen, J. H., Osmond, C., Barker, D. J., Ravelli, A. C., and Bleker, O. P. (2000). Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am. J. Clin. Nutr. 72, 1101–1106.
| 1:CAS:528:DC%2BD3cXnvF2nt78%3D&md5=ef89fc73461a7ead1d099c68954f4861CAS | 11063435PubMed |

Roseboom, T. J., van der Meulen, J. H., van Montfrans, G. A., Ravelli, A. C., Osmond, C., Barker, D. J., and Bleker, O. P. (2001). Maternal nutrition during gestation and blood pressure in later life. J. Hypertens. 19, 29–34.
Maternal nutrition during gestation and blood pressure in later life.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXns1Oktg%3D%3D&md5=b6d0c932f4b2ec39f87c52e9c38791b8CAS | 11204301PubMed |

Rumball, C. W., Bloomfield, F. H., and Harding, J. E. (2008). Cardiovascular adaptations to pregnancy in sheep and effects of periconceptional undernutrition. Placenta 29, 89–94.
Cardiovascular adaptations to pregnancy in sheep and effects of periconceptional undernutrition.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1c%2FisFKrtA%3D%3D&md5=d7901d4a1aa6dfdcc6f279961e2acac5CAS | 17945342PubMed |

Scientific Advisory Committee on Nutrition (SACN) (2011). ‘The Influence of Maternal, Fetal and Child Nutrition on the Development of Chronic Disease in Later Life.’ (Stationary Office Ltd: London.) Available at: http://www.sacn.gov.uk [Verified 10 September 2013].

Saez Lancellotti, T. E., Boarelli, P. V., Monclus, M. A., Cabrillana, M. E., Clementi, M. A., Espinola, L. S., Cid Barria, J. L., Vincenti, A. E., Santi, A. G., and Fornes, M. W. (2010). Hypercholesterolemia impaired sperm functionality in rabbits. PLoS One 5, e13457.
Hypercholesterolemia impaired sperm functionality in rabbits.Crossref | GoogleScholarGoogle Scholar | 20976152PubMed |

Samadian, F., Towhidi, A., Rezayazdi, K., and Bahreini, M. (2010). Effects of dietary n-3 fatty acids on characteristics and lipid composition of ovine sperm. Animal 4, 2017–2022.
| 1:CAS:528:DC%2BC3cXhtlGjsr%2FE&md5=c721016fc1e4e97f9ff5dc5dac10e24dCAS | 22445376PubMed |

Santos, J. E., Bilby, T. R., Thatcher, W. W., Staples, C. R., and Silvestre, F. T. (2008). Long chain fatty acids of diet as factors influencing reproduction in cattle. Reprod. Domest. Anim. 43, 23–30.
Long chain fatty acids of diet as factors influencing reproduction in cattle.Crossref | GoogleScholarGoogle Scholar | 18638102PubMed |

Seli, E., Gardner, D. K., Schoolcraft, W. B., Moffatt, O., and Sakkas, D. (2004). Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization. Fertil. Steril. 82, 378–383.
Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization.Crossref | GoogleScholarGoogle Scholar | 15302287PubMed |

Shah, D. K., Missmer, S. A., Berry, K. F., Racowsky, C., and Ginsburg, E. S. (2011). Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet. Gynecol. 118, 63–70.
Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization.Crossref | GoogleScholarGoogle Scholar | 21691164PubMed |

Sharkey, D. J., Macpherson, A. M., Tremellen, K. P., and Robertson, S. A. (2007). Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol. Hum. Reprod. 13, 491–501.
Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXotl2qurY%3D&md5=c49d0ccb77f27dd52f9f681b878bbaadCAS | 17483528PubMed |

Sinclair, K. D., Kuran, M., Gebbie, F. E., Webb, R., and McEvoy, T. G. (2000a). Nitrogen metabolism and fertility in cattle: II. Development of oocytes recovered from heifers offered diets differing in their rate of nitrogen release in the rumen. J. Anim. Sci. 78, 2670–2680.
| 1:CAS:528:DC%2BD3cXnsVarsb0%3D&md5=9d5b1c291f2022d82c3de12a0d1fb79bCAS | 11048933PubMed |

Sinclair, K. D., Sinclair, L. A., and Robinson, J. J. (2000b). Nitrogen metabolism and fertility in cattle: I. Adaptive changes in intake and metabolism to diets differing in their rate of energy and nitrogen release in the rumen. J. Anim. Sci. 78, 2659–2666.
| 1:CAS:528:DC%2BD3cXnsVarsbw%3D&md5=5671cdae8e52c1816ff06b269bebabc1CAS | 11048932PubMed |

Sinclair, K. D., Allegrucci, C., Singh, R., Gardner, D. S., Sebastian, S., Bispham, J., Thurston, A., Huntley, J. F., Rees, W. D., Maloney, C. A., Lea, R. G., Craigon, J., McEvoy, T. G., and Young, L. E. (2007). DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc. Natl Acad. Sci. USA 104, 19 351–19 356.
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXisVOjug%3D%3D&md5=7166c139de24e68c400d6f7925eb2cdaCAS |

Sinclair, K. D. (2010). Declining fertility, insulin resistance and fatty acid metabolism in dairy cows: developmental consequnces for the oocyte and pre-implantation embryo. Acta Scientiae Veterinariae 38, s545–s557.

Sinclair, K. D., and Kwong, W. Y. (2010). Determinants of egg and embryo quality: long-term effects of maternal diet and assisted reproduction. In ‘Maternal–Fetal Nutrition During Pregnancy and Lactation’. (Eds M. E. Symonds and M. M. Ramsay.) pp. 167–179. (Cambridge University Press: Cambridge, UK.)

Sjöblom, C., Roberts, C. T., Wikland, M., and Robertson, S. A. (2005). Granulocyte–macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis. Endocrinology 146, 2142–2153.
Granulocyte–macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis.Crossref | GoogleScholarGoogle Scholar | 15705781PubMed |

Sneed, M. L., Uhler, M. L., Grotjan, H. E., Rapisarda, J. J., Lederer, K. J., and Beltsos, A. N. (2008). Body mass index: impact on IVF success appears age-related. Hum. Reprod. 23, 1835–1839.
Body mass index: impact on IVF success appears age-related.Crossref | GoogleScholarGoogle Scholar | 18503054PubMed |

Soubry, A., Schildkraut, J. M., Murtha, A., Wang, F., Huang, Z., Bernal, A., Kurtzberg, J., Jirtle, R. L., Murphy, S. K., and Hoyo, C. (2013). Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. BMC Med. 11, 29.
Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXlvVaks7c%3D&md5=8824d0549c76879ba453a3ece812c20dCAS | 23388414PubMed |

Steegers-Theunissen, R. P. M., Twigt, J., Pestinger, V., and Sinclair, K. D. (2013). The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism. Hum. Reprod. Update , .
The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism.Crossref | GoogleScholarGoogle Scholar |

Steilmann, C., Paradowska, A., Bartkuhn, M., Vieweg, M., Schuppe, H. C., Bergmann, M., Kliesch, S., Weidner, W., and Steger, K. (2011). Presence of histone H3 acetylated at lysine 9 in male germ cells and its distribution pattern in the genome of human spermatozoa. Reprod. Fertil. Dev. 23, 997–1011.
Presence of histone H3 acetylated at lysine 9 in male germ cells and its distribution pattern in the genome of human spermatozoa.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtlWjt7bP&md5=f2c813edca009b41bc4c7eb293177836CAS | 22127005PubMed |

Stewart, T. M., Liu, D. Y., Garrett, C., Brown, E. H., and Baker, H. W. (2009). Recruitment bias in studies of semen and other factors affecting pregnancy rates in fertile men. Hum. Reprod. 24, 2401–2408.
Recruitment bias in studies of semen and other factors affecting pregnancy rates in fertile men.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1MnitVyrsA%3D%3D&md5=07e4401acc4d7f5c534f8019c20e97efCAS | 19553241PubMed |

Swann, K., Saunders, C. M., Rogers, N. T., and Lai, F. A. (2006). PLCζ(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals. Semin. Cell Dev. Biol. 17, 264–273.
PLCζ(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XntFSgsrY%3D&md5=6aec0ab1c07e16d2df6d7838c76a90d4CAS | 16730199PubMed |

Swayne, B. G., Kawata, A., Behan, N. A., Williams, A., Wade, M. G., Macfarlane, A. J., and Yauk, C. L. (2012). Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in BALB/c mice. Mutat. Res. 737, 1–7.
Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in BALB/c mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtlCjtLvM&md5=8b89be9190f15b7e21ed48c2ed653126CAS | 22824165PubMed |

Thangavelu, G., Colazo, M. G., Ambrose, D. J., Oba, M., Okine, E. K., and Dyck, M. K. (2007). Diets enriched in unsaturated fatty acids enhance early embryonic development in lactating Holstein cows. Theriogenology 68, 949–957.
Diets enriched in unsaturated fatty acids enhance early embryonic development in lactating Holstein cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtVOgsb7N&md5=f509d0762f73048a26bb6257da9663bdCAS | 17850856PubMed |

Thomas, S., Kratzsch, D., Schaab, M., Scholz, M., Grunewald, S., Thiery, J., Paasch, U., and Kratzsch, J. (2013). Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa. Fertil. Steril. 99, 1256–1263.e3.
| 1:CAS:528:DC%2BC3sXhvFSqurc%3D&md5=edb132732eb4bb94c2d1eefc68e5a739CAS | 23375204PubMed |

Todd, S. E., Oliver, M. H., Jaquiery, A. L., Bloomfield, F. H., and Harding, J. E. (2009). Periconceptional undernutrition of ewes impairs glucose tolerance in their adult offspring. Pediatr. Res. 65, 409–413.
Periconceptional undernutrition of ewes impairs glucose tolerance in their adult offspring.Crossref | GoogleScholarGoogle Scholar | 19092719PubMed |

Torrens, C., Snelling, T. H., Chau, R., Shanmuganathan, M., Cleal, J. K., Poore, K. R., Noakes, D. E., Poston, L., Hanson, M. A., and Green, L. R. (2009). Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Exp. Physiol. 94, 1024–1033.
Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtlWhsb3J&md5=24e76bf5cc5f70b6879ffd1c00360263CAS | 19561141PubMed |

Tremblay, R. R., Trottier, L., Abele, V., Nadeau, A., and Gagnon, P. (1985). Effect of streptozotocin-induced diabetes on insulin binding parameters in adult rat testis. Andrologia 17, 587–591.
Effect of streptozotocin-induced diabetes on insulin binding parameters in adult rat testis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL28Xht1OmtbY%3D&md5=6e58f1fc208959720730da00c674788cCAS | 3909853PubMed |

Vaidya, A., Saville, N., Shrestha, B. P., Costello, A. M., Manandhar, D. S., and Osrin, D. (2008). Effects of antenatal multiple micronutrient supplementation on children’s weight and size at 2 years of age in Nepal: follow-up of a double-blind randomised controlled trial. Lancet 371, 492–499.
Effects of antenatal multiple micronutrient supplementation on children’s weight and size at 2 years of age in Nepal: follow-up of a double-blind randomised controlled trial.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhslelurw%3D&md5=842adeda18d5d88283ab3e7e8148c032CAS | 18262041PubMed |

van der Heijden, G. W., Derijck, A. A., Ramos, L., Giele, M., van der Vlag, J., and de Boer, P. (2006). Transmission of modified nucleosomes from the mouse male germline to the zygote and subsequent remodeling of paternal chromatin. Dev. Biol. 298, 458–469.
Transmission of modified nucleosomes from the mouse male germline to the zygote and subsequent remodeling of paternal chromatin.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtVWqurnF&md5=4cdd5591ca63f6f834adc349a81615e4CAS | 16887113PubMed |

van der Heijden, G. W., Ramos, L., Baart, E. B., van den Berg, I. M., Derijck, A. A., van der Vlag, J., Martini, E., and de Boer, P. (2008). Sperm-derived histones contribute to zygotic chromatin in humans. BMC Dev. Biol. 8, 34.
Sperm-derived histones contribute to zygotic chromatin in humans.Crossref | GoogleScholarGoogle Scholar | 18377649PubMed |

VanDemark, N. L., Fritz, G. R., and Mauger, R. E. (1964). Effect of energy intake on reproductive performance of dairy bulls. II. Semen production and replenishment. J. Dairy Sci. 47, 898–904.
Effect of energy intake on reproductive performance of dairy bulls. II. Semen production and replenishment.Crossref | GoogleScholarGoogle Scholar |

Vonnahme, K. A., Zhu, M. J., Borowicz, P. P., Geary, T. W., Hess, B. W., Reynolds, L. P., Caton, J. S., Means, W. J., and Ford, S. P. (2007). Effect of early gestational undernutrition on angiogenic factor expression and vascularity in the bovine placentome. J. Anim. Sci. 85, 2464–2472.
Effect of early gestational undernutrition on angiogenic factor expression and vascularity in the bovine placentome.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtFSjtrvO&md5=9be9e12d2f226879c502d1bf4cbcaa68CAS | 17565057PubMed |

Wajchenberg, B. L. (2000). Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. 21, 697–738.
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3M7jslKntQ%3D%3D&md5=62a0238a2ae284fc978062d78300ad78CAS | 11133069PubMed |

Wakefield, S. L., Lane, M., Schulz, S. J., Hebart, M. L., Thompson, J. G., and Mitchell, M. (2008). Maternal supply of omega-3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse. Am. J. Physiol. Endocrinol. Metab. 294, E425–E434.
Maternal supply of omega-3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXit1ykur0%3D&md5=0f92a8e9d399562d498728f084fb714eCAS | 18073322PubMed |

Watkins, A. J., Ursell, E., Panton, R., Papenbrock, T., Hollis, L., Cunningham, C., Wilkins, A., Perry, V. H., Sheth, B., Kwong, W. Y., Eckert, J. J., Wild, A. E., Hanson, M. A., Osmond, C., and Fleming, T. P. (2008a). Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease. Biol. Reprod. 78, 299–306.
Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1Kru7c%3D&md5=0cb294e0fd8c46a87c89bf62e1cd074aCAS | 17989357PubMed |

Watkins, A. J., Wilkins, A., Cunningham, C., Perry, V. H., Seet, M. J., Osmond, C., Eckert, J. J., Torrens, C., Cagampang, F. R., Cleal, J., Gray, W. P., Hanson, M. A., and Fleming, T. P. (2008b). Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. J. Physiol. 586, 2231–2244.
Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXlsFent7Y%3D&md5=a4bb156186d57fb7d85935577f9b1324CAS | 18308825PubMed |

Watkins, A. J., Lucas, E. S., Wilkins, A., Cagampang, F. R., and Fleming, T. P. (2011). Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age. PLoS One 6, e28745.
Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xis1Wktg%3D%3D&md5=c920542d192b18d8e287fb35719d2471CAS | 22194901PubMed |

Wonnacott, K. E., Kwong, W. Y., Hughes, J., Salter, A. M., Lea, R. G., Garnsworthy, P. C., and Sinclair, K. D. (2010). Dietary omega-3 and -6 polyunsaturated fatty acids affect the composition and development of sheep granulosa cells, oocytes and embryos. Reproduction 139, 57–69.
Dietary omega-3 and -6 polyunsaturated fatty acids affect the composition and development of sheep granulosa cells, oocytes and embryos.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXovVWnug%3D%3D&md5=ee5da977df022e2e461fccec56508526CAS | 19789173PubMed |

Wright, I. A., and Russel, A. J. F. (1984). Partition of fat, body compsoition and body condition score in mature cows. Anim. Sci. 38, 23–32.

Wu, L. L., Dunning, K. R., Yang, X., Russell, D. L., Lane, M., Norman, R. J., and Robker, R. L. (2010). High-fat diet causes lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates. Endocrinology 151, 5438–5445.
High-fat diet causes lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhsVKks7bL&md5=7cd8735036dcedd8725aa523e38dd350CAS | 20861227PubMed |

Wu, L. L., Norman, R. J., and Robker, R. L. (2012). The impact of obesity on oocytes: evidence for lipotoxicity mechanisms. Reprod. Fertil. Dev. 24, 29–34.
The impact of obesity on oocytes: evidence for lipotoxicity mechanisms.Crossref | GoogleScholarGoogle Scholar |

Yap, D. B., Walker, D. C., Prentice, L. M., McKinney, S., Turashvili, G., Mooslehner-Allen, K., de Algara, T. R., Fee, J., de Tassigny, X., Colledge, W. H., and Aparicio, S. (2011). Mll5 is required for normal spermatogenesis. PLoS One 6, e27127.
Mll5 is required for normal spermatogenesis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsV2lu77M&md5=a37aab8fbfe57779e529b195ea0dc227CAS | 22069496PubMed |

Zachut, M., Dekel, I., Lehrer, H., Arieli, A., Arav, A., Livshitz, L., Yakoby, S., and Moallem, U. (2010). Effects of dietary fats differing in n-6:n-3 ratio fed to high-yielding dairy cows on fatty acid composition of ovarian compartments, follicular status, and oocyte quality. J. Dairy Sci. 93, 529–545.
Effects of dietary fats differing in n-6:n-3 ratio fed to high-yielding dairy cows on fatty acid composition of ovarian compartments, follicular status, and oocyte quality.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXht1Cjt7k%3D&md5=44bef32e93ac862d630043ad70c94cc9CAS | 20105525PubMed |

Zander, D. L., Thompson, J. G., and Lane, M. (2006). Perturbations in mouse embryo development and viability caused by ammonium are more severe after exposure at the cleavage stages. Biol. Reprod. 74, 288–294.
Perturbations in mouse embryo development and viability caused by ammonium are more severe after exposure at the cleavage stages.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xot1KlsA%3D%3D&md5=af3ab2bb18e365955188861d2f1b7d0cCAS | 16221986PubMed |

Zhang, S., Rattanatray, L., MacLaughlin, S. M., Cropley, J. E., Suter, C. M., Molloy, L., Kleemann, D., Walker, S. K., Muhlhausler, B. S., Morrison, J. L., and McMillen, I. C. (2010a). Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring. FASEB J. 24, 2772–2782.
Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtVeisbfI&md5=6fcfe1880d22a7077aa4cfa0bdb37702CAS | 20371620PubMed |

Zhang, D., Zhu, Y., Gao, H., Zhou, B., Zhang, R., Wang, T., Ding, G., Qu, F., Huang, H., and Lu, X. (2010b). Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women. Gynecol, Endocrinol 26, 325–332.
Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women.Crossref | GoogleScholarGoogle Scholar |

Zhu, M. J., Du, M., Hess, B. W., Nathanielsz, P. W., and Ford, S. P. (2007). Periconceptional nutrient restriction in the ewe alters MAPK/ERK1/2 and PI3K/Akt growth signaling pathways and vascularity in the placentome. Placenta 28, 1192–1199.
Periconceptional nutrient restriction in the ewe alters MAPK/ERK1/2 and PI3K/Akt growth signaling pathways and vascularity in the placentome.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtF2qtrnF&md5=f11c07a0082b66d0ae3f553077e56083CAS | 17586041PubMed |