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Dietary propylene glycol and in vitro embryo production after ovum pick-up in heifers with different anti-Müllerian hormone profiles

G. Gamarra A B , C. Ponsart A , S. Lacaze B , B. Le Guienne A , P. Humblot C , M.-C. Deloche A , D. Monniaux D E F G and A. A. Ponter H I J

A UNCEIA Département Recherche et Développement, 13 rue Jouet, F-94704 Maisons-Alfort, France.
B MIDATEST, Domine de Sensacq cedex 55A, F-64230 Denguin, France.
C Division of Reproduction, Department of Clinical Sciences, Faculty of Veterinary Medicine and Agricultural Sciences, Swedish University of Agricultural Sciences, PO Box 7054, SE 75007 Uppsala, Sweden.
D INRA, UMR85 Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France.
E CNRS, UMR7247, F-37380 Nouzilly, France.
F Université François Rabelais de Tours, F-37041 Tours, France.
G IFCE, F-37380 Nouzilly, France.
H Université Paris Est, Ecole Nationale Vétérinaire d’Alfort, UMR 1198 Biologie du Développement et Reproduction, F-94704 Maisons-Alfort, France.
I INRA, UMR 1198 Biologie du Développement et Reproduction, Domaine de Vilvert, F-78350 Jouy-en-Josas, France.
J Corresponding author. Email: aponter@vet-alfort.fr

Reproduction, Fertility and Development - http://dx.doi.org/10.1071/RD14091
Submitted: 11 March 2014  Accepted: 11 May 2014   Published online: 24 July 2014


 
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Abstract

Rapid genetic improvement in cattle requires the production of high numbers of embryos of excellent quality. Increasing circulating insulin and/or glucose concentrations improves ovarian follicular growth, which may improve the response to superovulation. The measurement of anti-Müllerian hormone (AMH) can help predict an animal’s response to superovulation treatment. The aim of the present study was to investigate whether increasing circulating insulin concentrations, through propylene glycol (PG) drenches, could improve in vitro embryo production in oestrus-synchronised superovulated heifers with different AMH profiles. Holstein heifers were grouped according to pre-experimental AMH concentrations as low (L) or high (H). The PG drench increased circulating insulin and glucose concentrations and reduced β-hydroxybutyrate and urea concentrations compared with the control group. AMH was a good predictor of follicle and oocyte numbers at ovum pick-up (OPU), and of oocyte and embryo quality (AMH H > AMH L). PG in the AMH H group increased the number of follicles and blastocyst quality above that in the control group, but did not improve these parameters in the AMH L group. These results indicate that short-term oral PG supplementation modifies an animal’s metabolic milieu and is effective in improving in vitro embryo production, after superovulation–OPU, more markedly in heifers with high rather than low AMH concentrations.

Additional keywords: cattle fertility, follicle growth, insulin, insulin-like growth factor 1, oocyte quality, superovulation.


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