Prospects for new oocyte-based assisted reproduction in animals and humans
David F. Albertini
+ Author Affiliations
- Author Affiliations
Center for Human Reproduction, c/o Ovistagen LLC, 233 Beach Road, Unit C2, Salisbury, MA 01952, USA. Email: eicjarg@gmail.com
Reproduction, Fertility and Development 32(2) 7-10 https://doi.org/10.1071/RD19271
Published: 2 December 2019
Abstract
Procuring high-quality oocytes is the rate-limiting step for assisted reproduction technologies intended for embryo production. Although much is known about the intraovarian processes that dictate oocyte growth and maturation, subtleties in the process of oogenesis have yet to be replicated in in vitro systems. In contrast with the mouse, in which functional oocytes have been derived from stem cells under ex vivo conditions, the generation of developmentally competent oocytes in other species has yet to be achieved. This paper reviews the principles and practices based on stem cell and organ culture strategies that hold promise for developing a technological base upon which future efforts to recapitulate or augment oogenesis in mammals could be realised.
Additional keywords: assisted reproductive technology, oogenesis, stem cell.
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