Australian Journal of Zoology Australian Journal of Zoology Society
Evolutionary, molecular and comparative zoology
RESEARCH ARTICLE

Hatching time for monotreme immunology

Emily S. W. Wong A , Anthony T. Papenfuss B , Robert D. Miller C and Katherine Belov A D

A Faculty of Veterinary Science, B19 RMC Gunn, University of Sydney, Sydney, NSW 2006, Australia.

B Bioinformatics Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Vic. 3052, Australia.

C Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA.

D Corresponding author. Email: kbelov@vetsci.usyd.edu.au

Australian Journal of Zoology 57(4) 185-198 http://dx.doi.org/10.1071/ZO09042
Submitted: 7 April 2009  Accepted: 6 July 2009   Published: 26 October 2009

Abstract

The sequencing of the platypus genome has spurred investigations into the characterisation of the monotreme immune response. As the most divergent of extant mammals, the characterisation of the monotreme immune repertoire allows us to trace the evolutionary history of immunity in mammals and provide insights into the immune gene complement of ancestral mammals. The immune system of monotremes has remained largely uncharacterised due to the lack of specific immunological reagents and limited access to animals for experimentation. Early immunological studies focussed on the anatomy and physiology of the lymphoid system in the platypus. More recent molecular studies have focussed on characterisation of individual immunoglobulin, T-cell receptor and MHC genes in both the platypus and short-beaked echidna. Here, we review the published literature on the monotreme immune gene repertoire and provide new data generated from genome analysis on cytokines, Fc receptors and immunoglobulins. We present an overview of key gene families responsible for innate and adaptive immunity including the cathelicidins, defensins, T-cell receptors and the major histocompatibility complex (MHC) Class I and Class II antigens. We comment on the usefulness of these sequences for future studies into immunity, health and disease in monotremes.


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