Furoate Based Functionalised Ionic Liquid: Antimicrobial and Antioxidant Studies
R. Rama
A C , S. Meenakshi A , J. Manjunathan B , G. Abirami B and S. Karthikeyan A
A Department of Chemistry, School of Basic Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India.
B Department of Biotechnology, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India.
C Corresponding author. Email: rama.ragu10@gmail.com
Australian Journal of Chemistry 74(3) 186-191 https://doi.org/10.1071/CH20178
Submitted: 2 June 2020 Accepted: 11 August 2020 Published: 15 September 2020
Abstract
A tetraalkyl ammonium cation and furoate anion based functionalised ionic liquid (FIL), N-methyl-N,N,N-trioctylammonium furoate ([MTOA]+[FA]–) has been synthesised and characterised using FT-IR, NMR, and UV spectroscopic techniques. The in vitro antimicrobial activity of the synthesised FIL against two types of Gram-positive bacteria, namely Staphylococcus aureus and Enterobacter faecalis as well as Gram-negative bacteria, namely Escherichia coli and Pseudomonas aeruginosa was tested using a well diffusion method. Similarly, an antifungal test was done against Candida albicans. [MTOA]+[FA]– showed significant inhibitory effect against all the organisms tested as compared with the chosen standards. Antibacterial activity against gram-positive bacteria (zone of inhibition: 16 to 30 mm) was found to be higher than that of Gram-negative bacteria (zone of inhibition: 11 to 19 mm). Moreover, the antioxidant activity of the synthesised FIL from a ferrous ion (Fe2+) chelating assay and its scavenging activity against 1,1-diphenyl-2-picrylhydrazyl, H2O2, and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) free radical using spectrophotometric methods are reported. The FIL, [MTOA]+[FA]– showed a moderate antioxidant activity.
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