Just Accepted
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A peptide journey through the scientific discoveries of David Craik – a personal reflection
Abstract
Prof. David Craik has profoundly influenced modern peptide science through his pioneering work on peptide cyclization, structural biology, and the molecular logic behind nature’s own mechanisms for macrocyclization. Best known for the discovery and characterization of cyclotides – cyclic plant peptides stabilized by a cystine knot – David and team defined not only their topological features but also the enzymatic machinery underlying their biosynthesis. His work laid the biochemical and structural foundations for understanding how nature produces stabilized peptides and how this stability can be harnessed for practical applications.
CH25082 Accepted 01 September 2025
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