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REVIEW
Contents Vol 73(4)

Towards Peptide and Protein Recognition by Antibody Mimicking Synthetic Polymers – Background, State of the Art, and Future Outlook*

Ian A. Nicholls https://orcid.org/0000-0002-0407-6542 A B and Jesper G. Wiklander https://orcid.org/0000-0002-2042-4818 A
+ Author Affiliations
- Author Affiliations

A Bioorganic and Biophysical Chemistry Laboratory, Linnaeus Centre for Biomaterials Chemistry, Department of Chemistry and Biomedical Sciences, Linnaeus University, SE-391 82 Kalmar, Sweden.

B Corresponding author. Email: ian.nicholls@lnu.se




After Ph.D. studies at the University of Melbourne (1989), Ian A. Nicholls pursued post-doctoral research at Cambridge and Lund universities and held a series of lecturing positions at Lund and Kalmar universities. In 2000, he was appointed to a chair in chemistry at the University of Kalmar (now Linnaeus University). His current research is focused on biomimetic recognition systems and their use for chemical catalysis, sensing, and therapeutic applications.


Jesper Wiklander completed his M.Sc. in biomedical chemistry and Ph.D. in organic chemistry (2004) at the University of Kalmar (now Linnaeus University). His Ph.D. and subsequent research has been focused on establishing the mechanisms underlying molecularly imprinted polymer–ligand recognition behaviour and using molecularly imprinted materials in biosensing and biomaterials applications.

Australian Journal of Chemistry 73(4) 300-306 https://doi.org/10.1071/CH20020
Submitted: 17 January 2020  Accepted: 20 February 2020   Published: 12 March 2020

Abstract

Antibody–peptide/protein interactions are instrumental for many processes in the pharmaceutical and biotechnology industries and as tools for biomedical and biochemical research. The recent development of molecularly imprinted polymer nanoparticles displaying antibody-like recognition of peptides and proteins offers the possibility for substituting antibodies with these robust materials for applications where the structural integrity and function of antibodies is compromised by temperature, pH, solvent, etc. The background to the development of this class of antibody-mimicking material and the state-of-the-art in their synthesis and application is presented in this review.


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