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Australian Journal of Chemistry

Australian Journal of Chemistry

Australian Journal of Chemistry - an International Journal for Chemical Science publishes research papers from all fields of chemical science, with a focus on multidisciplinary chemistry and emerging areas of research. Read more about the journalMore

Editors-in-Chief: George Koutsantonis and John Wade

Publishing Model: Hybrid. Open Access options available.

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Latest

These articles are the latest published in the journal. Australian Journal of Chemistry is published under a continuous publication model. More information is available on our Continuous Publication page.

Published online 25 July 2025

CH25086Rational design and selection of next-generation cyclotide drugs using the knotted cyclic peptide scaffold MCoTI-II

Sven Ullrich 0000-0003-4184-7024, Grégoire Jean-Baptiste Philippe 0000-0001-8103-9211, Choi Yi Li 0000-0001-8823-3666 and Hiroaki Suga 0000-0002-5298-9186
 

Schematic showing the solution structure of MCoTI-II with cystine-knotted disulfide bridges highlighted.

This mini-review highlights tactics to engineer MCoTI-II, a cyclic cystine-knot peptide natural product, into next-generation therapeutics and diagnostics. Through both rational modification and genetically encoded selection platforms, variants of the MCoTI-II cyclotide have been developed for a diverse range of potential biomedical applications. (Image credit: Sven Ullrich.)

This article belongs to the collection: 70th Birthday tribute to Prof. David Craik.

CH25086 Abstract  | PDF (1.4 MB) - $35.00 
Published online 21 July 2025

CH25070The value of telling it like it was. The best honours project ever?

Christopher Barnett 0000-0002-8818-6908, Thomas Maschmeyer, Anthony F. Masters and Alexander K. L. Yuen 0000-0002-6908-8851
 

Cartoon by Sidney Harris of a reviewer of a chemical process saying ‘I think you should be more explicit here in step two’ where it says ‘Then a miracle occurs’

Undergraduate students should appreciate that chemical understanding is not static; what we teach is our ‘best guess’ to explain observables. Textbooks frequently conflate (and often incorrectly describe) the concept of the nucleus, inferred by Rutherford from Marsden’s ‘gold foil’ experiment, with the model of the nucleus, containing protons and neutrons, despite nearly 25 years between these advances. We argue that an opportunity is lost in the teaching of chemistry, to illustrate to students the incremental progress in chemistry and that the ‘wrong’ explanation can be very useful. (Image credit: © Sidney Harris, originally appearing in American Scientist in 1977, reproduced with permission.)

CH25070 Abstract  |  CH25070 Full Text  | CH25070PDF (780 KB)   Open Access Article

Published online 16 July 2025

CH25059The development of a bioassay expressing the human MRGPRX2 receptor for ex vivo drug discovery

Jan Tytgat 0000-0003-1778-6022
 

Illustration of the action of a venom on MRGPRX2. The GIRK1/2 channel opens, generating a flow of inward K current.

Mast cells of our immune system are generally difficult and expensive to maintain in vitro and, therefore, not economical to use in drug discovery. The development of a bioassay expressing the human mas-related G protein-coupled receptor-X2 receptor linked to potassium channels in a host cell offers a good alternative. (Image credit: Jan Tytgat.)

This article belongs to the collection: 70th Birthday tribute to Professor David Craik.

CH25059 Abstract  |  CH25059 Full Text  | CH25059PDF (1.2 MB)   Open Access Article

Published online 10 July 2025

CH25030The cooperative effect of CPC micelles and RuIII on the rate enhancement of L-tyrosine oxidation by N-bromosuccinimide

Abhishek Srivastava 0000-0003-2463-1213, Vinay Kumar Singh and Neetu Srivastava 0009-0009-0482-510X
 

Conceptual illustration of RuIII-catalysed oxidation of L-Tyr by NBS in an acidic CPC micellar medium.

In the CPC micellar environment, the more hydrophobic reactant component (L-Tyrosine) and the extended aliphatic chain of CPC reside in the micelle’s core. The micelle Stern layer preserves the polar components of the surfactant (Me3N+), substrate (–NH2, and –COOH) and reactive species of NBS and RuIII in proximity, hence promoting the oxidation of L-Tyr. The elevated concentration of reactant molecules at the micellar interface enhances the effective collision frequency among the reacting molecules, significantly promoting the oxidation process. (Image credit: Abhishek Srivastava.)

CH25030 Abstract  | PDF (1.6 MB) - $35.00 
Published online 17 June 2025

CH25013Experimental and theoretical investigation of the relative catalytic activities of triphenylphosphine and N-heterocyclic carbene in oxa–Michael addition of phenols

Priyanka Suthar, Ruchi Singh, Rashi Bala Vyas and Raj K. Bansal 0000-0002-8154-9817
 

A schematic of how phenols react with DMAD in the presence of phosphine or NHC as catalyst to give aryl vinyl ethers by the Michael reaction

The catalytic activities of triphenylphosphine and N-heterocyclic carbene, namely 3-benzyl-4,5-dimethylthiazolylidene, have been compared by carrying out oxa–Michael additions of some phenols with dimethyl acetylenedicarboxylate in the presence of one of these catalysts. The experimental results have been rationalised on the basis of theoretical calculations. (Image credit: Priyanka Suthar.)

CH25013 Abstract  | PDF (1.5 MB) - $35.00   | CH25013Supplementary Material (1.7 MB)
Published online 16 June 2025

CH24117Valencene derived from essential oils of Psidium guajava L. as multi-target neurodegenerative inhibitor: a computational study

Ram Lal Swagat Shrestha, Sujan Dhital 0009-0000-2384-1687, Nirmal Parajuli, Prabhat Neupane, Manila Poudel 0009-0007-7753-5168, Timila Shrestha, Samjhana Bharati, Binita Maharjan, Bishnu Prasad Marasini 0000-0001-6153-5234 and Jhashanath Adhikari Subin
 

Schematic showing compounds present in Psidium guajava and graphics of the associated proteins that were evaluated against neurodegenerative disorders.

The compounds present in Psidium guajava L. were evaluated against three different proteins (PDB ID: 4A79, 7E3H, 7F61) associated with the regulation of neurodegenerative diseases. Using a computational approach, these compounds were tested for their capability to inhibit the proteins. The resultssupport the potential of P. guajava compounds in managing neurodegenerative disorders. (Image credit: the authors.)

CH24117 Abstract  |  CH24117 Full Text  | CH24117PDF (2.1 MB)  | CH24117Supplementary Material (588 KB)   Open Access Article

Published online 04 June 2025

CH25006closo-Borate aryliodonium zwitterions: convenient intermediates for functional closo-borane derivatives and molecular materials

Piotr Kaszynski 0000-0002-2325-8560
 

Schematic of the functionalization of closo-borates through aryliodonium zwitterions.

This review summarizes the formation, structure, stability and reactions of aryliodonium zwitterions of closo-borate anions. The zwitterions are formed by regioselective aryliodination of closo-borates with ArIII reagents and undergo efficient reactions with nucleophiles. Therefore, this tandem of reactions represents an effective regioselective activation of the B–H bonds in closo-borates towards nucleophilic substitution. (Image credit: Piotr Kaszyński.)

CH25006 Abstract  |  CH25006 Full Text  | CH25006PDF (4 MB)   Open Access Article

Published online 12 May 2025

CH24160Synthesis and anti-hepatic fibrosis activity of novel matrine tricyclic derivatives

Yongchuang Wang, Hang Yang, Wenming Tang, Luozhu Zhou, Chuanhao Wang, Anhua Huang, Daozuan Zhang, Zheng Yao, Wei Li, Wannian Zhang, Yuelin Wu, Weiheng Xu and Zhenyuan Miao 0000-0001-7839-4183
 

Structure of matrine and its tricyclic derivative alongside its effect on TGF-β1-induced expression of collagen I and α-SMA in LX-2 cells.

Novel matrine tricyclic derivatives have been designed and synthesised by a molecular fusion strategy. The most active compound ZM842 indicated potent inhibitory TGF-β transcriptional activity in a dose-dependent manner by downregulating collagen I and α-SMA protein. (Image credit: Yongchuang Wang.)

CH24160 Abstract  | PDF (1.5 MB) - $35.00   | CH24160Supplementary Material (2.8 MB)
Published online 12 May 2025

CH25002Ionic liquid-assisted synthesis of pyrrole derivative: a green and sustainable method

Vaishali, Shubham Sharma 0000-0002-9657-6623, Preeti Jain, Ankush Thakur, Sobhi M. Gomha and Swati Rani
 

Synthesis of tether and fused pyrrole derivatives using ionic liquids as solvent and catalyst from 2001 to 2024.

Green synthesis is garnering global interest among researchers due to its distinctive characteristics and ecological advantages. Researchers are developing innovative ionic liquids (ILs) and enhancing their characteristics for application in green chemistry and synthesis, including environmentally friendly solvents and catalysts. They have been extensively used as green catalysts and solvent systems for the synthesis of many important heterocycles because of their distinctive features. (Image credit: Shubham Sharma.)

CH25002 Abstract  | PDF (3 MB) - $35.00 
Published online 12 May 2025

CH24163Ring-expansion reactions of Cyrene and derivatives with ethyl diazoacetate

Johannes Puschnig, Oscar Lamb, Christopher J. Sumby and Ben W. Greatrex 0000-0002-0356-4966
 

Reaction scheme for the ring-expansion of Cyrene with ethyl diazoacetate and subsequent decarboxylation.

Levoglucosenone and the reduced analogue Cyrene are versatile chiral intermediates for synthesis, available from the cellulose fraction of biomass by acid-catalysed pyrolysis. An ethyl diazoacetate mediated ring expansion has been developed for Cyrene, and combination with a decarboxylation has resulted in homologated ring-systems. Some selected reactions for the first homologated ring-system were then investigated. (Image credit: Ben Greatrex.)

CH24163 Abstract  |  CH24163 Full Text  | CH24163PDF (909 KB)  | CH24163Supplementary Material (2 MB)   Open Access Article

Published online 02 April 2025

CH24055The electrophilic cyanation of alkynyl halides (bromides or chlorides) with N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) using a zinc reagent

Yan Chen, Xiaotong Zhang, Xiao Yun Chen 0000-0002-0443-1305 and Cui-Feng Yang
 

Efficient low-toxicity synthesis of substituted propiolonitriles using electrophilic cyanation with eco-friendly NCTS.

The Zn-mediated environmentally friendly and low-cost preparation of propiolonitriles using electrophilic cyanation of alkynyl bromides with N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) has been achieved here. In this new protocol, only low-toxicity, stable and easy-to-handle cyanating reagents, NCTS and inexpensive zinc dust were needed. (Image credit: Xiao Yun Chen.)

CH24055 Abstract  | PDF (838 KB) - $35.00   | CH24055Supplementary Material (4 MB)
Published online 17 March 2025

CH24130Three decades of quantum science: how quantum chemistry transformed thermochemical database generation for benchmarking DFT and machine learning

Amir Karton 0000-0002-7981-508X
 

Image of showing three methods, Computational Chemistry, Chemical Databases and Machine Learning, that have revolutionised chemical databases for DFT benchmarking and ML applications

This review underscores the pivotal role of high-level composite wavefunction methods in revolutionising the construction of highly accurate thermochemical databases. These breakthroughs are critical for generating large-scale thermochemical datasets, which are crucial for advancing density functional theory (DFT) methods and improving machine-learning models to enable more reliable chemical predictions. (Image credit: A. Karton.)

CH24130 Abstract  |  CH24130 Full Text  | CH24130PDF (1.3 MB)   Open Access Article

Published online 14 March 2025

CH24146Synthesis of novel mono BN substituted symmetrical and asymmetrical perylene diimides for fluoride anion detection

Luna Yang, Yifan Wang, Chenhao Wang, Feng Liu 0000-0001-9815-4187, Weiping Chen, Yonggang Wu and Hongchi Zhao
 

Schematics of three novel mono BN substituted perylene diimide (PDI) derivatives and images of HeLa cells treated with PDI-BN1.

Three novel mono BN substituted derivatives (PDI-BN1, PDI-BN2 and PDI-BN3) of symmetrical and asymmetrical perylene diimides were designed and efficiently synthesised using a concise synthetic strategy. These derivatives exhibited orange fluorescence, with their properties finely adjustable by integrating various fused aryl rings. Except for F− ions, these derivatives have shown no affinity for other anions. (Image credit: Feng Liu.)

CH24146 Abstract  | PDF (2.3 MB) - $35.00   | CH24146Supplementary Material (7.3 MB)
Published online 04 February 2025

CH24086AuNPs synthesised in situ from self-assembled peptide hydrogels modulating peptide secondary structure

Bin Huang, Lingyi Li, Fuzhen Yan, Fangjie Liu 0009-0003-8550-4012, Jin Zhang, Linlin Zhong and Wenlong Xu
 

Schematic diagram of hydrogel preparation and mechanism.

An amphiphilic peptide Fmoc-FFCKK-OH was designed to induce peptide self-assembly to form hydrogels by Au3+ ligand interaction. This study contributes to further understanding the role of AuNPs binding specifically to peptides in the formation of β-sheet-like aggregates and provides a research basis for AuNPs as amyloid aggregation regulator. (Image credit: Fangjie Liu.)

CH24086 Abstract  | PDF (3.5 MB) - $35.00   | CH24086Supplementary Material (330 KB)

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These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.

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Collections

Collections are a curation of articles relevant to a topical research area

70th Birthday tribute to Professor David Craik

This collection presents papers submitted as a tribute to Professor David Craik on the occasion of his 70th birthday.

Guest Editors
Prof. Ed Nice (Monash University), Prof. Mibel Aguilar (Monash University) & Prof. John Wade (The Florey)

Last Updated: 25 Jul 2025

Beckwith Review Series

Beckwith Reviews honour the memory of Professor Athelstan (Athel) L. J. Beckwith, a remarkable man and an outstanding chemist. These invited reviews advance knowledge in current key areas of research in chemistry.

Last Updated: 04 Jun 2025

10th Anniversary Collection of RACI and AAS Award papers

This collection presents papers submitted by 2023–24 Australian Academy of Science and Royal Australian Chemical Institute Award winners.

All papers in this collection are Open Access and the foreword by the Guest Editor, Curt Wentrup of the School of Chemistry and Molecular Biosciences at The University of Queensland, is free to read.

Last Updated: 10 Oct 2024

Primer Review Series

Primer Reviews are concise, authoritative overviews of important contemporary topics in the chemical sciences. They should appeal to advanced undergraduates, the general research chemist who is new to the field, as well as the expert. They provide a solid introduction to the development of a subject, the latest breakthrough results and their implications for the wider scientific community.

Last Updated: 12 Sep 2024

Cornforth Review Series

Cornforth Reviews honour the memory of Sir John Warcup Cornforth (usually known as Kappa to friends and colleagues). These invited reviews advance knowledge in current key areas of research in chemistry.

Last Updated: 22 Aug 2024

The Medicinal Chemistry Collection

Australian Journal of Chemistry is approaching its eighth decade of publishing key work across many spheres of chemistry, both national and international. As the current co-editors-in-chief, we are delighted to introduce this collection that highlights a selection of the finest recent articles in medicinal chemistry. We are proud to also highlight the significant contributions to medicinal chemistry research made by several outstanding women researchers.

Collection Editors
John Wade and George Koutsantonis

Last Updated: 01 Oct 2020

70 Years of Australian Journal of Chemistry: A Retrospective

This collection reflects the breadth and quality of science published in the Australian Journal of Chemistry by Australian scientists over the last seven decades. Papers were selected based on hard data (citations and downloads), but we also chose papers that reflect other criteria, such as landmarks in important aspects of chemical science; recognition of an influential individual; gender diversity; and simply to reflect the breadth of the journal’s output.

Last Updated: 07 Feb 2019

Nobel Laureates

Australian Journal of Chemistry is proud to have published the works of a number of Nobel prize winners of chemistry. This collection brings together the articles authored by these Nobel prize winners.

Last Updated: 01 Nov 2012

Committee on Publication Ethics

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