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Article << Previous     |     Next >>   Contents Vol 64(3)

Uptake and Distribution of a Platinum(ii)-Carborane Complex Within a Tumour Cell Using Synchrotron XRF Imaging

Ellen L. Crossley A, Jade B. Aitken A, Stefan Vogt B, Hugh H. Harris C and Louis M. Rendina A D

A School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
B X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA.
C School of Chemistry and Physics, The University of Adelaide, SA 5005, Australia.
D Corresponding author. Email: lou.rendina@sydney.edu.au

Australian Journal of Chemistry 64(3) 253-257 http://dx.doi.org/10.1071/CH10453
Submitted: 10 December 2010  Accepted: 14 February 2011   Published: 11 March 2011


 
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Abstract

Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex containing a PtII-terpy (terpy = 2,2′:6′,2′′-terpyridine) unit linked to a functionalized closo-carborane cage results in the uptake of the complex within the cells, as determined by synchrotron X-ray fluorescence (XRF) imaging. Although a significant cellular uptake of Pt existed, there was no significant accumulation of the element within the cell nuclei. Other statistically significant changes from the XRF data included an increase in Cl, K, and Cu and a decrease in Fe within the treated cells.





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