New Macrocyclic Ligands. XIII. Single-Ring and Tri-Linked Macrocyclic Systems Derived from Selectively Protected Cyclam

Abstract

The selective use of the tert-butoxycarbonyl protecting group has enabled efficient syntheses of the tri-linked cyclam derivatives (6)–(8). Using a related protecting group strategy, a series of related single-ring, N-benzylated cyclam derivatives (1)–(4) has also been prepared.