A Direct Synthesis of 2-Deoxy-2-fluoro-α-D-[6-3H]glucopyranosyl Uridine-5´-diphosphate

Abstract

The synthesis of 2-deoxy-2-fluoro-α-D-[6-³H]glucopyranosyl uridine-5´-diphosphate, with the late introduction of the radiolabel, has been achieved from 3,4-di-O-benzyl-2-deoxy-2-fluoro-α-D-glucosyl diphenyl phosphate, by an oxidation-reduction sequence, followed by protecting group removal and morpholidate coupling to uridine-5´-monophosphate.