Synthesis, Chemical Characterisation, and DNA Binding Studies of Ferrocene-Incorporated Selenoureas
Raja Azadar Hussain A , Amin Badshah A C , Muhammad Nawaz Tahir B , Bhajan Lal A and Inayat Ali Khan A
+ Author Affiliations
- Author Affiliations
A Coordination Chemistry Laboratory, Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
B Department of Physics, University of Sargodha, Punjab, Pakistan.
C Corresponding author. Email: aminbadshah@yahoo.com
Australian Journal of Chemistry 66(6) 626-634 https://doi.org/10.1071/CH12570
Submitted: 4 January 2013 Accepted: 5 February 2013 Published: 12 March 2013
Abstract
In this article we have presented the synthesis, chemical characterisation (by NMR and FTIR spectroscopy, atomic absorption spectrophotometry, elemental analysis, and single crystal X-ray diffraction), electrochemistry, and DNA binding studies (with cyclic voltammetry, viscometry, and UV-vis spectroscopy) of six new ferrocene incorporated selenoureas. All the six compounds interact electrostatically with DNA which was evident by a negative shift in the cyclic voltammetry peak potential of the drug–DNA adduct relative to the free drug. The drug–DNA binding constant was calculated by a decrease in peak current after the addition of DNA to the free drug. We have also reported binding site sizes and diffusion coefficients of the synthesised compounds.
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