Al(OTf)3 Catalysed Friedel-Crafts Michael Type Addition of Indoles to α,β-Unsaturated Ketones with PEG-200 as Recyclable Solvent

Mukut Gohain; Jc Jacobs; Charlene Marais; Barend C. B. Bezuidenhoudt

doi:10.1071/CH13254

RESEARCH ARTICLE

Previous Contents Vol 66(12)

Al(OTf)₃ Catalysed Friedel-Crafts Michael Type Addition of Indoles to α,β-Unsaturated Ketones with PEG-200 as Recyclable Solvent

Mukut Gohain ^A , Jc Jacobs ^A , Charlene Marais ^A and Barend C. B. Bezuidenhoudt ^A ^B

+ Author Affiliations

- Author Affiliations

^A Department of Chemistry, University of the Free State, PO Box 339, Bloemfontein 9300, South Africa.

^B Corresponding author. Email: bezuidbc@ufs.ac.za

Australian Journal of Chemistry 66(12) 1594-1599 https://doi.org/10.1071/CH13254
Submitted: 14 May 2013 Accepted: 31 August 2013 Published: 6 November 2013

Abstract

An Al(OTf)₃ catalysed efficient Friedel–Crafts Michael type addition of indoles to α,β-unsaturated ketones using recyclable PEG-200 as an alternative reaction solvent is disclosed. The reaction under microwave irradiation is clean, leads to excellent yields in minutes and reduces the use of volatile organic compounds.

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Al(OTf)3 Catalysed Friedel-Crafts Michael Type Addition of Indoles to α,β-Unsaturated Ketones with PEG-200 as Recyclable Solvent

Abstract

References

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Al(OTf)₃ Catalysed Friedel-Crafts Michael Type Addition of Indoles to α,β-Unsaturated Ketones with PEG-200 as Recyclable Solvent