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RESEARCH ARTICLE
Contents Vol 75(4)

Research progress on hydroxyl protection of iridoid glycosides

Yuanfang Kong https://orcid.org/0000-0002-9220-4275 A * , Bin Yang A , Jingyu Zhang A and Chunhong Dong B C D *
+ Author Affiliations
- Author Affiliations

A College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China.

B Henan Polysaccharide Research Center, Zhengzhou, Henan 450046, China.

C Henan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou, Henan 450046, China.

D Academy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China.




Yuanfang Kong received her master’s degree from Lanzhou University. In 2018, she graduated from Nankai University with a doctorate degree in organic chemistry. She now teaches at Henan University of Chinese Medicine and her research direction is drug design, synthesis and development and application. In recent years, she has contributed towards more than 20 research papers that have been published in academic journals, such as Organic Letters, Advanced Synthesis & Catalysis and European Journal of Organic Chemistry. She has received approval for two invention patents.


Bin Yang is from Handan in Hebei, China. She studied medicinal chemistry at Henan University of Chinese Medicine, completing her undergraduate degree in 2019. She is pursuing her master’s degree at Henan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs in Henan University of Chinese Medicine. Her research focuses on the structural modification and biological activity evaluation of iridoid glycosides.


Jingyu Zhang, PhD, professor of Henan University of Chinese Medicine. His research direction is drug design, synthesis and development and application. Zhang Jingyu has presided over the China Postdoctoral Science Fund, Henan Province Science and Technology Research Project, Zhengzhou City Science and Technology Research Project, University Basic Research Business Fee Project and the Henan University of Traditional Chinese Medicine Innovation Talents Program. In recent years, he has contributed towards 30 research papers published in academic journals, such as Journal of Advanced Research, Analytica Chimica Acta, Tetrahedron Letters and European Journal of Medicinal Chemistry. He has received approval for three invention patents.


Chunhong Dong, PhD, professor of Henan University of Chinese Medicine. Her research direction is drug design, synthesis and development and application. Chunhong Dong has published more than 50 academic papers and presided over six key scientific and technological projects of the National Natural Science Foundation of China and Henan Province. She has received approval for five invention patents.
* Correspondence to: kongyf@hactcm.edu.cn

Handling Editor: Manabu Abe

Australian Journal of Chemistry 75(4) 249-264 https://doi.org/10.1071/CH21260
Submitted: 5 October 2021  Accepted: 31 January 2022   Published: 13 April 2022

© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing.

Abstract

Iridoids, an important active ingredient, are widely distributed in varieties of Chinese herbal medicines and have varieties of pharmacological activities, such as anti-tumor, hypoglycemic, anti-inflammatory and so on, most of which exist in the form of glycosides in nature. However, its clinical application is limited by poor lipid solubility, low bioavailability and short half-life. It is necessary to optimize the structure of iridoids. It is hard to modify the hydroxyl groups at specific sites because iridoid glycosides are polyhydroxy compounds and very complex. In this paper, the words of ‘Iridoid glycosides’ and ‘Hydroxyl protection’ were used as the keywords, more than 200 articles from 1965 to 2021 were obtained from databases, such as CNKI, PubMed, Scifinder and so on. Finally, 60 articles were selected to summarize the hydroxyl protection of iridoid glycosides, which will provide a theoretical basis for their structural modification and stimulate their application potential in the field of drug research and development.

Keywords: hydroxyl deprotection, hydroxyl protection, iridoid glycosides, natural product, polyhydroxy compounds, progress, research, structural modifications.


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