The preparation of some dipeptides containing asparagine, aspartic acid, and glutamine

Abstract

Several methods have been used to synthesize dipeptides of asparagine, glutamine, and aspartic acid. Not all techniques were found to be equally applicable to the synthesis of a particular peptide. The methods examined involved the use of the chloracetyl-, phthalyl-, and carbobenzoxy- residues as protective groups and the use of acid chlorides, mixed carbonic anhydrides, phosphite amides, and isocyanate esters in the coupling reaction.