Pyrimidine reactions. VI. The amination of chloropyrimidines with n-alkylamines

Abstract

The aminations of 2-chloro-4,6-dimethylpyrimidine and 4-chloro-2,6-dimethyl- pyrimidine by a series of n-alkylamines (3 moles) have been followed titrimetrically. Between 3° and 70° the rates of these apparently first-order reactions approximately double for each 10" rise. A simple experimental method for predicting optimum conditions of temperature and time for such aminations has been developed. Addition of cuprous chloride has little effect on rates. Fifteen new n-alkylaminopyrimidines have been prepared.