The synthesis and chemistry of 2-Methylpyrimidine-4,6-dithiol and some related compounds

Abstract

2-Methylpyrimidine-4,6-dithiol has been synthesized and has been converted into 2-methyl-6- methylthiopyrimidine-4-thiol, 4,6-bismethylthiopyrimidine and 6,6'-dithiobis(2-methylpyrimidine-4- thiol). Oxidation of 4,6-bismethylthio-2-methylpyrimidine with 1, 2, 3 and 4 equiv. of m-chloroper- benzoic acid has been shown to result in the formation of the easily isolable methylsulfinyl(methylthio)-, bis(dimethylsulfinyl)-, methylsulfinyl(methylsulfonyl)- and bismethylsulfonyl-pyrimidine, respectively. Some further reactions of the above compounds are described and the synthesis of some other pyrimidines having sulfur-containing substituents is also described.