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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
Australian Journal of Chemistry

Australian Journal of Chemistry

Volume 76 Number 4 2023

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Flavonols have an active regulatory effect on organisms, and they have been used to form new types of photoinduced CO-releasing molecules (photoCORMs) with superior application prospects. A range of photoCORMs based on flavonol derivatives were synthesized and screened. PhotoCORM 3a, with a fast CO-release rate and low cytotoxicity, can penetrate the cell membrane well into the cytoplasm, and release 0.03 moles of CO in mice. PhotoCORM 3a can potenitally be utilized as a molecular tool to study the biological effects of CO in organisms, with applications in biomedicine.

CH22224Synthesis of hydrogels incorporating core–shell structured Fe3O4@ZIF-8 as bio-nanocomposite carriers for drug delivery

Pagasukon Mekrattanachai 0000-0002-3374-0254, Naruemon Setthaya, Chakkresit Chindawong, Bunlawee Yotnoi, Wei Guo Song and Chawan Manaspon 0000-0001-8961-7901
pp. 201-208
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A nanocomposite Fe3O4@ZIF-8-loaded hydrogel significantly exhibited good biocompatibility toward L929 fibroblast cells. This indicated that the Fe3O4@ZIF-8-loaded hydrogel could potentially be an impressive bio-nanocomposite carrier for drug delivery applications.

CH23069Evaluation of the 5-ethynyl-1,3,3-trimethyl-3H-indole ligand for molecular materials applications

David Jago 0000-0002-8696-5545, David C. Milan 0000-0002-6569-2816, Alexandre N. Sobolev, Simon J. Higgins 0000-0003-3518-9061, Andrea Vezzoli 0000-0002-8059-0113, Richard J. Nichols 0000-0002-1446-8275 and George A. Koutsantonis 0000-0001-8755-3596
pp. 209-230
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A series of organometallic σ-alkynyl complexes incorporating the 3H-indole moiety were designed and synthesised. The complexes were studied using electrochemical and spectroelectrochemical techniques. The N-heteroatom of the indole ligand showed Lewis base properties and could extract a proton from a vinylidene intermediate and coordinate to CuI.

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