Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
Australian Journal of Chemistry

Australian Journal of Chemistry

Volume 66 Number 5 2013

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Important advancements have been made in recent years in the development of chemoselective additions of nucleophiles to well known inert amide carbonyls in the presence of multi-electrophilic substrates. Herein, we present the most relevant results showing how carbonyl amides can be chemoselectively functionalised in the presence of electrophilic functionalities such as Weinreb amides.

CH12514A Review of Catalytic Systems for Glycerol Oxidation: Alternatives for Waste Valorization

Juan Carlos Beltrán-Prieto, Karel Kolomazník and Jiří Pecha
pp. 511-521
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The oxidation of glycerol that is generated as a by-product of the transesterification of animal fat and vegetable oils leads to the formation of aldehydes, carboxylic acids, and ketones. It is one of the most important challenges in chemistry because the conversion and selectivity for a specific product vary according to the reaction conditions, catalyst selected, and oxidation method.

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When liquid water is subjected to ionizing radiation it breaks down to hydrogen, hydroxyl, superoxide, and peroxide radicals, and solvated electrons all of which have the potential to change redox conditions in subsurface environments. This process might have an adverse effect in trace metal partitioning in nature.

CH13035Telomerase Inhibition Studies of Novel Spiroketal-Containing Rubromycin Derivatives

Tsz-Ying Yuen, Yu-Pong Ng, Fanny C. F. Ip, Jack L.-Y. Chen, Darcy J. Atkinson, Jonathan Sperry, Nancy Y. Ip and Margaret A. Brimble
pp. 530-533
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Rubromycins are potent quinone-containing inhibitors of human telomerase. Given that previous studies have implicated the spiroketal ring to be the active moiety in telomerase inhibition, we synthesised various heterocyclic analogues based on the rubromycin core in order to evaluate their telomerase inhibitory potential.

CH12218Kinetic Studies on the Reactions of [(TLtBu)PtCl]+ and [Pt(tpdm)Cl]+ Complexes with Some Thiols and Thioethers

Enisa Selimović, Biljana Petrović, Dragan Čc;anović, Živadin D. Bugarčić and Jovana Bogojeski
pp. 534-538
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The kinetics and mechanism of the substitution reactions of the complexes [(TLtBu)PtCl]+ and [Pt(tpdm)Cl]+ with S-methyl-L-cysteine (S-Met-L-Cys), L-cysteine (L-Cys), glutathione (GSH) and L-methionine (L-Met) were studied. The order of reactivity of studied ligands is: S-Met-L-Cys > L-Met > GSH > L-Cys. The complex [Pt(tpdm)Cl]+ is more reactive than [(TLtBu)PtCl]+.

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A series of seven CoII, CdII, ZnII, MnII, and NiII supramolecular complexes have been constructed using 2,5-bis(4-pyridyl)-1,3,4-oxadiazole and 2-phenylacetate generated in situ from the hydrothermal decarboxylation of 2-phenylmalonic acid, which show diverse structures regulated by inorganic salts and solid-state fluorescence at room temperature.

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Two new ligands and their ruthenium(ii) complexes [Ru(bpy)2(NHPIP)]2+ (Ru-1), [Ru(phen)2(NHPIP)]2+ (Ru-2), [Ru(bpy)2(AHPIP)]2+ (Ru-3), and [Ru(phen)2(AHPIP)]2+ (Ru-4) have been synthesized and characterized. Their cytotoxcity in vitro, apoptosis, cellular uptake, cell cycle arrest, mitochondrial membrane potentials, DNA binding, and photocleavage were investigated.

CH12484Ni/MWCNT-Supported Palladium Nanoparticles as Magnetic Catalysts for Selective Oxidation of Benzyl Alcohol

Mingmei Zhang, Qian Sun, Zaoxue Yan, Junjie Jing, Wei Wei, Deli Jiang, Jimin Xie and Min Chen
pp. 564-571
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Uniformly dispersed Pd@Ni bimetallic nanoparticles (4 nm) on multi-walled carbon nanotubes are prepared and used as catalysts for the oxidation of benzyl alcohol resulting in a 99 % conversion and demonstrating a higher catalytic activity than that of a Pd/MWCNT catalyst at the same Pd loadings. The catalyst is easily isolatable due to its magnetic properties.

CH12557Monitoring the Early Stage Self-Assembly of Enzyme-Assisted Peptide Hydrogels

Richard J. Williams, James Gardiner, Anders B. Sorensen, Silvia Marchesan, Roger J. Mulder, Keith M. McLean and Patrick G. Hartley
pp. 572-578
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The early stage kinetics of the enzyme catalysed self-assembly of an ultra short peptide hydrogel was examined. Gels formed within minutes at physiological pH to give fibrous ordered networks. Lag times associated with the sol-gel transition points were characterised to reveal a minimum concentration of self-assembling species required for hydrogel formation. 1H NMR spectroscopy was also used to monitor hydrogel formation and measure reaction rates during early stages of self-assembly.

CH12457Effect of pH, Buffer, and Viscosity on the Photolysis of Formylmethylflavin: A Kinetic Study

Iqbal Ahmad, Tania Mirza, Kefi Iqbal, Sofia Ahmed, Muhammad Ali Sheraz and Faiyaz H. M. Vaid
pp. 579-585
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Photolysis of formylmethylflavin (FMF) takes place by a bimolecular redox reaction involving a triplet state and a ground-state molecule followed by the formation of charged and neutral radicals. The neutral radicals may give rise to degradation products. The rate of reaction is influenced by pH, phosphate buffer, and solvent viscosity.

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A novel diol-functionalized poly(ethylene glycol)-bridged dicationic ionic liquid ([diol-PEG1000-DIL][PF6]) was prepared and used as an efficient and reusable ligand for copper-catalyzed amination.

CH12537Aggregation of Hydrogen Bonded Dimeric Tri-Organotin Amino Substituted Pyrimidine-2-Thiolates

Anastasia Ioannidou, Agnieszka Czapik, Petros Gkizis, Muhamad Perviaz, Dimitrios Tzimopoulos, Maria Gdaniec and Pericles D. Akrivos
pp. 600-606
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Six tri-organotin thiolates with 4-amino and 4,6-diaminothiolate are studied. The compounds form stable dimers through intermolecular hydrogen bonds. Further aggregation in the solid state, propagated through interdimer weak N–H⋯RS and N–H⋯Rπ interactions, gives different three-dimensional networks.

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Professor Kenneth Seddon OBE, one of AJC’s longest-standing Editors, sadly passed away on 21 January from prostate cancer. Ken was one of the world's best ionic liquids experts. His consistent unwavering support, loyalty and advocacy for AJC over the last 10 years will be sorely missed.