This account summarises the approach of conformationally coupled diversity-oriented synthesis (CDOS) for enhancing specificity in ligand–protein interactions. Stereospecific fluorination of natural product fragments produces new synthons for tuning the conformational dynamics of bioactive leads. This integrated chemical and conformational perturbation can differentiate highly homologous protein active sites by combined chemical and conformational effects.

A novel adsorbent was used to adsorb PtCl₆²⁻. The saturation adsorption capacity was 218.8 mg g⁻¹ and the equilibrium adsorption time was 120 min. The adsorption fitted well with the Langmuir isotherm model and pseudo-second-order kinetics model. The adsorption mechanism indicated that Pt^IV was reduced to Pt^II and then coordinated with N.

We present a pathway to synthesize diatrizoate lanthanoid complexes directly from Ln₂O₃ and diatrizoic acid (DTAH) at room temperature, yielding [Ln(H₂O)₈][DTA]₃. The compounds crystallized from DMSO have the formula [Ln(DMSO)₄(H₂O)₄][DTA]₃.DMSO whereas the compound obtained solely from water has the formula [Dy(H₂O)₈][DTA]₃.7H₂O.

A highly sensitive and selective microbead-based ‘turn-on’ assay has been developed for the detection of Hg²⁺ in urine based on the Hg²⁺-mediated formation of intermolecular split G-quadruplex–hemin DNAzymes. The detection limit is 0.5 pM. The method can be easily extended to the analysis of other metal ions in real samples.

The structure of fullerene is equally influenced by either trapping of Li or F atoms making a minor change in bond distances as analyzed by the DFT approach. The charge transfer analysis shows that the C₆₀ is a better electron acceptor than electron donor which is further supported by the dipole moment and binding energy values.

The formation mechanism and effects on the size of droplets in a T-junction were successfully investigated by numerical simulation. The results show that the effective droplet diameter increases when the flow rate ratio and the interfacial tension increase, and it decreases when the continuous phase viscosity and the contact angle increase.

TiO₂ is the centre of attraction of many photocatalysts and is often combined with other semiconductors to expand the photocatalytic activity. Researchers use the theory of interparticle electron transfer (IPET) to interpret the enhancement of photoactivity. The recently reported direction of photogenerated electron transfer is coincident with the semiconductor physical principles, not IPET.

A quantum dots-based fluorescent probe obtained via ligand exchange by the use of commercially available p-hydroxy thiophenol as capping ligand was developed to detect H₂O₂ in aqueous media. The probe working in photoluminescence ‘off-on’ mode exhibited good H₂O₂ detection performance in real water samples.

A new zinc-based porous metal–organic framework (MOF) has been successfully prepared under solvothermal conditions. Due to its suitable channel size and good stability in biological buffer solutions, compound 1 has been used as a carrier for loading the anticancer drug 5-fluorouracil though a simple adsorption process. The drug-loaded MOF demonstrates a physiological pH responsive drug release.

Strawberry-like core–shell nanostructured oxygen-enriched boron nitride microsphere/calcium borate (BNO/CB) nanocomposites were synthesised by a reverse micro-emulsion method. Sliding friction is transformed into rolling friction with the addition of the nanocomposites and excellent friction reduction and antiwear properties can be obtained.