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Solid-Phase O-Glycosylation with Glucosamine derivative for the Synthesis of Glycopeptide
An efficient synthesis of O-linked glycosylamino acid [Fmoc-L-Ser((Ac)3-β-D-GlcNAc)-OH] building block is described. The utility of the method was demonstrated with direct solid-phase O-glycosylation of hydroxyl group on amino acid (Ser) side chain of human α-A crystallin derived peptide (AIPVS*REEK) in nearly quantitative glycosylation yield.
CH17201 Accepted 16 June 2017
© CSIRO 2017