This article has been peer reviewed and accepted for publication. It is in production and has not been edited, so may differ from the final published form.
An injectable oxidized carboxymethyl cellulose/polyacryloyl hydrazide hydrogel via Schiff base reaction
A series of injectable hydrogels were prepared by cross-linking oxidized carboxymethyl cellulose (oxi-CMC) with polyacryloyl hydrazide (PAH) via Schiff base reaction under physiological condition. The hydrogels exhibited superior performance such as appropriate rheology properties, high swelling ratio and low degradation rate. In phosphate buffer solution (PBS, pH 7.4) at 37 ℃, the swelling ratio of hydrogels ranged from 19 to 28 after 7 hours, the degradation percentage of oxi-CMC6/PAH3 hydrogel was about 47% after 20 days. Using bovine serum albumin (BSA) as a model protein drug, the results of in vitro drug release studies demonstrated that the sustained release of BSA could be cooperatively controlled through drug diffusion and hydrogel degradation in PBS solution (pH 7.4) at 37 ℃, and the cumulative release percentage of BSA from drug-loaded oxi-CMC6/PAH3 hydrogel was about 88% after 8 days. The results signified that oxi-CMC6/PAH3 hydrogels could be potentially applied in the fields of drug delivery vehicle, tissue engineering and cell encapsulation materials.
CH17214 Accepted 08 September 2017
© CSIRO 2017