This article has been peer reviewed and accepted for publication. It is in production and has not been edited, so may differ from the final published form.
Regioselective Synthesis of 2, 5-Disubstituted Pyrroles via Stepwise Iododesilylation and Coupling Reactions
Abstract: A new protocol has been developed for the regioselective preparation of 2, 5-disubstituted pyrroles. This approach is based on the stepwise iododesilylation and a subsequent coupling reaction, involving a 6-step pathway starting from the simplest pyrrole. A variety of 2, 5-disubstituted pyrrole derivatives are accessible in moderate to good yields.
CH17341 Accepted 02 October 2017
© CSIRO 2017