Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science

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Regioselective Synthesis of 2, 5-Disubstituted Pyrroles via Stepwise Iododesilylation and Coupling Reactions

Qixin Yu , Xiaoyu Li , Xinyue Wang , Jianhui Liu


Abstract: A new protocol has been developed for the regioselective preparation of 2, 5-disubstituted pyrroles. This approach is based on the stepwise iododesilylation and a subsequent coupling reaction, involving a 6-step pathway starting from the simplest pyrrole. A variety of 2, 5-disubstituted pyrrole derivatives are accessible in moderate to good yields.

CH17341  Accepted 02 October 2017

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