An Alternative Synthesis of Some Carbohydrate α-Amino Acids

Abstract

Several carbohydrate ketones have been converted into their trichloromethyl-branched tertiary alcohols. A subsequent treatment of these alcohols under Corey–Link conditions (base, sodium azide, methanol) has given rise to α-azido esters, transformable into azido acids, amino esters, and amino acids. An amino ester and an azido acid have been coupled to form a dipeptide.