A New Synthetic Protocol for One-Pot Preparations of 5-Halo-1,4-disubstituted-1,2,3-triazoles

Lingjun Li; Yanyan Li; Ran Li; Anlian Zhu; Guisheng Zhang

doi:10.1071/CH11067

RESEARCH ARTICLE

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A New Synthetic Protocol for One-Pot Preparations of 5-Halo-1,4-disubstituted-1,2,3-triazoles

Lingjun Li ^A ^B , Yanyan Li ^A , Ran Li ^A , Anlian Zhu ^A and Guisheng Zhang ^A

+ Author Affiliations

- Author Affiliations

^A College of Chemistry and Environmental Science, Henan Normal University, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Xinxiang 453007, China.

^B Corresponding author. Email: lingjunlee@htu.cn

Australian Journal of Chemistry 64(10) 1383-1389 https://doi.org/10.1071/CH11067
Submitted: 11 February 2011 Accepted: 2 June 2011 Published: 23 August 2011

Abstract

In this paper, a new synthetic protocol for one-pot preparations of 5-halo-1,4-disubstituted-1,2,3-triazoles is provided by rational combination of a Cu^I catalyzed azide–alkyne cycloaddition (CuAAC) reaction and an oxidative halogenation reaction. CuI- N-chlorosuccinimide (NCS) and CuBr-NCS reaction systems are developed, respectively, for effective preparations of 5-iodo-1,4-disubstituted-1,2,3-triazoles and 5-bromo-1,4-disubstituted-1,2,3-trizoles under mild conditions with a high tolerance of various sensitive groups.

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A New Synthetic Protocol for One-Pot Preparations of 5-Halo-1,4-disubstituted-1,2,3-triazoles

Abstract

References

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