Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH FRONT

Applications of Mass Spectrometry in Proteomics

Izabela Sokolowska A , Armand G. Ngounou Wetie A , Alisa G. Woods A B and Costel C. Darie A C

A Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699-5810, USA.

B Neuropsychology Clinic and Psychoeducation Services, SUNY Plattsburgh, Plattsburgh, NY 12901, USA.

C Corresponding author. Email: cdarie@clarkson.edu




Izabela Sokolowska received her M.Sc. in biotechnology at Warsaw University of Life Sciences (2009) and currently she is a Ph.D. student in the Biochemistry and Proteomics Group at Clarkson University. Her research is focused on the characterisation of newly discovered protein tumour differentiation factors (TDFs) and mass spectrometry-based approaches in the analysis of proteins.



Armand G. Ngounou Wetie received his diploma in biotechnology (2008) from the Mannheim University of Applied Sciences, Germany, and a Master of Science degree in molecular biotechnology from the Technical University of Munich (TUM), Germany. Currently, Armand is a Ph.D. student in the Department of Chemistry and Biomolecular Science at Clarkson University (Potsdam, New York), where he is working on understanding the mode of action of the tumour differentiation factor (TDF) protein.



Dr Alisa Woods is a neurobiologist and mental health counsellor, and currently Research Assistant Professor in the Department of Chemistry and Biomolecular Science at Clarkson University, as well as Counsellor and Neuropsychology Researcher at the Neuropsychology Clinic/Psychoeducation Services, SUNY Plattsburgh, New York. The long-term goal of her research is to understand the connections between biochemistry and behaviour in neurodevelopmental disorders, including autism and ADHD. She is particularly interested in the identification of protein biomarkers for diagnosis and prognosis of neurodevelopmental disorders, and in their use for monitoring the psychotherapeutic/behavioural treatment of developmental disorders.



Dr Costel C. Darie is a biochemist and currently Assistant Professor and leader of the Biochemistry and Proteomics Group within the Department of Chemistry and Biomolecular Science at Clarkson University. He received his B.S. and M.S. in biochemistry from Iasi, Romania, and his Ph.D. in biochemistry from Freiburg, Germany. Dr Darie's main research interests are in new proteomics approaches for biomarker discovery and identification of post-translational modifications and protein–protein interactions. His research is also focused on the investigation of one particular protein – the tumour differentiation factor protein.

Australian Journal of Chemistry 66(7) 721-733 http://dx.doi.org/10.1071/CH13137
Submitted: 27 March 2013  Accepted: 14 May 2013   Published: 3 June 2013

Abstract

Characterisation of proteins and whole proteomes can provide a foundation to our understanding of physiological and pathological states and biological diseases or disorders. Constant development of more reliable and accurate mass spectrometry (MS) instruments and techniques has allowed for better identification and quantification of the thousands of proteins involved in basic physiological processes. Therefore, MS-based proteomics has been widely applied to the analysis of biological samples and has greatly contributed to our understanding of protein functions, interactions, and dynamics, advancing our knowledge of cellular processes as well as the physiology and pathology of the human body. This review will discuss current proteomic approaches for protein identification and characterisation, including post-translational modification (PTM) analysis and quantitative proteomics as well as investigation of protein–protein interactions (PPIs).

Graphical Abstract Image


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