Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH FRONT

Genome-Guided Discovery of Natural Products and Biosynthetic Pathways from Australia’s Untapped Microbial Megadiversity

John A. Kalaitzis A , Shane D. Ingrey A , Rocky Chau A , Yvette Simon A and Brett A. Neilan A B
+ Author Affiliations
- Author Affiliations

A School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

B Corresponding author. Email: b.neilan@unsw.edu.au

Australian Journal of Chemistry 69(2) 129-135 https://doi.org/10.1071/CH15601
Submitted: 24 September 2015  Accepted: 20 November 2015   Published: 21 December 2015

Abstract

Historically microbial natural product biosynthesis pathways were elucidated mainly by isotope labelled precursor directed feeding studies. Now the genetics underpinning the assembly of microbial natural products biosynthesis is so well understood that some pathways and their products can be predicted from DNA sequences alone. The association between microbial natural products and their biosynthesis gene clusters is now driving the field of ‘genetics guided natural product discovery’. This account overviews our research into cyanotoxin biosynthesis before the genome sequencing era through to some recent discoveries resulting from the mining of Australian biota for natural product biosynthesis pathways.


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