Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science

Cyclodextrin Inclusion Complexes of Two Non-Steroidal Antiinflammatory Drugs and of an Analgesic Drug

SE Brown, JH Coates, CJ Easton, SF Lincoln, Y Luo and AKW Stephens

Australian Journal of Chemistry 44(6) 855 - 862
Published: 1991


U.v .-visible spectrophotometric studies of the interactions of Naproxen, Ibuprofen and Panadol with α-cyclodextrin , β-cyclodextrin, γ-cyclodextrin and dimethyl β- cyclodextrin enable the determination of stability constants of inclusion complexes when their formation gives rise to appreciable spectral changes. The magnitudes of the stability constants are discussed in terms of the relative sizes and the chemical natures of the cyclodextrins and the included molecules.

© CSIRO 1991

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