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Unexpected Isomerisation of a Fragment Analogue During Fragment-Based Screening of HIV Integrase Catalytic Core Domain

John H. Ryan A E , Karen E. Jarvis A , Roger J. Mulder A , Craig L. Francis A , G. Paul Savage A , Olan Dolezal B , Thomas S. Peat B and John J. Deadman C D
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A CSIRO Biomedical Manufacturing Program, Bayview Avenue, Clayton, Vic. 3168, Australia.

B CSIRO Biomedical Manufacturing Program, 343 Royal Parade, Parkville, Vic. 3052, Australia.

C Avexa Pty Ltd, Level 1, 61–63 Camberwell Road, Hawthorn East, Vic. 3123, Australia.

D Current address: Chemocopeia Pty Ltd, 157 Arnold Street, Melbourne, Vic. 3054, Australia.

E Corresponding author. Email: jack.ryan@csiro.au

Australian Journal of Chemistry 68(12) 1871-1879 https://doi.org/10.1071/CH15587
Submitted: 20 September 2015  Accepted: 9 October 2015   Published: 6 November 2015



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