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An Efficient Chemical Synthesis of Lassomycin Enabled by an On-Resin Lactamisation–Off-Resin Methanolysis Strategy and Preparation of Chemical Variants

Paul W. R. Harris A B E , Gregory M. Cook B D , Ivanhoe K. H. Leung A and Margaret A. Brimble A B C
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A School of Biological Sciences, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.

B Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.

C School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.

D Department of Microbiology and Immunology, School of Medical Sciences, University of Otago, 720 Cumberland Street, Dunedin 9054, New Zealand.

E Corresponding author. Email: paul.harris@auckland.ac.nz

Australian Journal of Chemistry 70(2) 172-183 https://doi.org/10.1071/CH16499
Submitted: 7 September 2016  Accepted: 7 October 2016   Published: 28 October 2016



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