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Australian Journal of Chemistry

Australian Journal of Chemistry

Australian Journal of Chemistry - an International Journal for Chemical Science publishes research papers from all fields of chemical science, with a focus on multidisciplinary chemistry and emerging areas of research. Read more about the journalMore

Editors-in-Chief: George Koutsantonis and John Wade

Publishing Model: Hybrid. Open Access options available.

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Latest

These articles are the latest published in the journal. Australian Journal of Chemistry is published under a continuous publication model. More information is available on our Continuous Publication page.

Published online 29 August 2025

CH25081Electrophilic fragment screening using native mass spectrometry to identify covalent probes for surface cysteines

Jack W. Klose 0000-0002-4084-1870, Yezhou Yu 0009-0007-9173-549X, Giovanna Di Trapani 0000-0003-2583-5832, Kathryn F. Tonissen 0000-0002-1018-2798, Louise M. Sternicki 0000-0001-6158-663X and Sally-Ann Poulsen 0000-0003-4494-3687
 

Schematic of surface exposed cysteine residues of carbonic anhydrase III and a spectrum of native mass spectrometry peaks.

Native mass spectrometry (nMS) was applied to screen an electrophilic covalent fragment library to identify ligands for the surface exposed cysteine residues of a soluble protein (carbonic anhydrase III), to determine which cysteines were modified and to measure the simultaneous binding of an orthosteric noncovalent inhibitor and covalent fragment hit. (Image credit: S.-A. Poulsen and L. M. Sternicki.)

This article belongs to the collection: 70th Birthday tribute to Professor David Craik.

CH25081 Abstract  |  CH25081 Full Text  | CH25081PDF (2 MB)  | CH25081Supplementary Material (1.3 MB)   Open Access Article

Published online 27 August 2025

CH25035A red-emission fluorescent probe for monitoring polarity changes during ER stress induced by DTT

Xue Zhang, Feiyang Ding, Jiale Li, Aobo Sun, Sichen Zhang, Jie Wang, Lei Hu and Hui Wang 0000-0002-5253-1204
 

Three schematics showing the molecular structures of the ER-targeting compounds, and two confocal images of HepG2 cells.

A series of red-emission compounds (ER-A, ER-B, ER-C) have been constructed using methyl sulfonamide as the ER-targeting moiety. These compounds can effectively detect environmental polarity changes within a defined range. ER-A exhibits high ER localisation accuracy (colocalisation coefficient = 0.9) and detects polarity changes under ER stress. This work provides a novel tool for monitoring ER polarity and studying related diseases. (Image credit: Xue Zhang.)

CH25035 Abstract  | PDF (2.7 MB) - $35.00   | CH25035Supplementary Material (1.6 MB)
Published online 12 August 2025

CH25050An unusual triterpene fatty acid conjugate from Dodonaea caespitosa

Andrew M. Bloomfield 0000-0003-4449-6872, Eugene Eades, Hendra Gunosewoyo 0000-0003-3897-1948 and Alan D. Payne 0000-0003-4530-6348
 

Chemical structure of the betulin conjugate 2 extracted from Dodonaea caespitosa.

The south-west of Western Australia is a biodiversity hotspot, where collaborations between local communities and scientists play a pivotal role in the study of native plants. The leaf resin of Dodonaea caespitosa, growing in Nowanup, contained only two compounds, one of which was an unusual bioconjugate comprising a triterpene, a cutin monomer and a p-hydroxycinnamate. This natural product was the first isolated to date and will help our understanding of the biology and ecology of this plant. (Image credit: Andrew M. Bloomfield.)

CH25050 Abstract  |  CH25050 Full Text  | CH25050PDF (836 KB)  | CH25050Supplementary Material (5.5 MB)   Open Access Article

Published online 05 August 2025

CH25003Friedel–Crafts chemistry. Part 64. Facile syntheses of fused azepinoindoles by Jourdan–Ullmann and Friedel–Crafts approaches

Hassan A. K. Abd El-Aal 0000-0003-4158-6960
 

Friedel–Crafts cyclisations of indole carboxylic acids or indole alcohols to tetracyclic azopinoindoles.

Indole fused N-heterocycles form the structural core of a large number of natural products and pharmaceuticals. These properties make them exciting targets for synthetic chemists, with a wide range of synthetic methodologies reported. However, these often have a number of drawbacks, including cost, scalability and low yields. Herein, we explore an efficient construction of benzo-, pyrido-, thieno-, naphtho-fused azepinoindolones and indolo-azepinoquinolinones from readily available starting materials through Lewis and Brønsted acid mediated Friedel–Crafts reactions. (Image credit: Hassan A. K. Abd El-Aal.)

CH25003 Abstract  | PDF (1.1 MB) - $35.00   | CH25003Supplementary Material (8.4 MB)
Published online 25 July 2025

CH25086Rational design and selection of next-generation cyclotide drugs using the knotted cyclic peptide scaffold MCoTI-II

Sven Ullrich 0000-0003-4184-7024, Grégoire Jean-Baptiste Philippe 0000-0001-8103-9211, Choi Yi Li 0000-0001-8823-3666 and Hiroaki Suga 0000-0002-5298-9186
 

Schematic showing the solution structure of MCoTI-II with cystine-knotted disulfide bridges highlighted.

This mini-review highlights tactics to engineer MCoTI-II, a cyclic cystine-knot peptide natural product, into next-generation therapeutics and diagnostics. Through both rational modification and genetically encoded selection platforms, variants of the MCoTI-II cyclotide have been developed for a diverse range of potential biomedical applications. (Image credit: Sven Ullrich.)

This article belongs to the collection: 70th Birthday tribute to Prof. David Craik.

CH25086 Abstract  | PDF (1.4 MB) - $35.00 
Published online 21 July 2025

CH25070The value of telling it like it was. The best honours project ever?

Christopher Barnett 0000-0002-8818-6908, Thomas Maschmeyer, Anthony F. Masters and Alexander K. L. Yuen 0000-0002-6908-8851
 

Cartoon by Sidney Harris of a reviewer of a chemical process saying ‘I think you should be more explicit here in step two’ where it says ‘Then a miracle occurs’

Undergraduate students should appreciate that chemical understanding is not static; what we teach is our ‘best guess’ to explain observables. Textbooks frequently conflate (and often incorrectly describe) the concept of the nucleus, inferred by Rutherford from Marsden’s ‘gold foil’ experiment, with the model of the nucleus, containing protons and neutrons, despite nearly 25 years between these advances. We argue that an opportunity is lost in the teaching of chemistry, to illustrate to students the incremental progress in chemistry and that the ‘wrong’ explanation can be very useful. (Image credit: © Sidney Harris, originally appearing in American Scientist in 1977, reproduced with permission.)

CH25070 Abstract  |  CH25070 Full Text  | CH25070PDF (780 KB)   Open Access Article

Published online 16 July 2025

CH25059The development of a bioassay expressing the human MRGPRX2 receptor for ex vivo drug discovery

Jan Tytgat 0000-0003-1778-6022
 

Illustration of the action of a venom on MRGPRX2. The GIRK1/2 channel opens, generating a flow of inward K current.

Mast cells of our immune system are generally difficult and expensive to maintain in vitro and, therefore, not economical to use in drug discovery. The development of a bioassay expressing the human mas-related G protein-coupled receptor-X2 receptor linked to potassium channels in a host cell offers a good alternative. (Image credit: Jan Tytgat.)

This article belongs to the collection: 70th Birthday tribute to Professor David Craik.

CH25059 Abstract  |  CH25059 Full Text  | CH25059PDF (1.2 MB)   Open Access Article

Published online 10 July 2025

CH25030The cooperative effect of CPC micelles and RuIII on the rate enhancement of L-tyrosine oxidation by N-bromosuccinimide

Abhishek Srivastava 0000-0003-2463-1213, Vinay Kumar Singh and Neetu Srivastava 0009-0009-0482-510X
 

Conceptual illustration of RuIII-catalysed oxidation of L-Tyr by NBS in an acidic CPC micellar medium.

In the CPC micellar environment, the more hydrophobic reactant component (L-Tyrosine) and the extended aliphatic chain of CPC reside in the micelle’s core. The micelle Stern layer preserves the polar components of the surfactant (Me3N+), substrate (–NH2, and –COOH) and reactive species of NBS and RuIII in proximity, hence promoting the oxidation of L-Tyr. The elevated concentration of reactant molecules at the micellar interface enhances the effective collision frequency among the reacting molecules, significantly promoting the oxidation process. (Image credit: Abhishek Srivastava.)

CH25030 Abstract  | PDF (1.6 MB) - $35.00 
Published online 17 June 2025

CH25013Experimental and theoretical investigation of the relative catalytic activities of triphenylphosphine and N-heterocyclic carbene in oxa–Michael addition of phenols

Priyanka Suthar, Ruchi Singh, Rashi Bala Vyas and Raj K. Bansal 0000-0002-8154-9817
 

A schematic of how phenols react with DMAD in the presence of phosphine or NHC as catalyst to give aryl vinyl ethers by the Michael reaction

The catalytic activities of triphenylphosphine and N-heterocyclic carbene, namely 3-benzyl-4,5-dimethylthiazolylidene, have been compared by carrying out oxa–Michael additions of some phenols with dimethyl acetylenedicarboxylate in the presence of one of these catalysts. The experimental results have been rationalised on the basis of theoretical calculations. (Image credit: Priyanka Suthar.)

CH25013 Abstract  | PDF (1.5 MB) - $35.00   | CH25013Supplementary Material (1.7 MB)
Published online 16 June 2025

CH24117Valencene derived from essential oils of Psidium guajava L. as multi-target neurodegenerative inhibitor: a computational study

Ram Lal Swagat Shrestha, Sujan Dhital 0009-0000-2384-1687, Nirmal Parajuli, Prabhat Neupane, Manila Poudel 0009-0007-7753-5168, Timila Shrestha, Samjhana Bharati, Binita Maharjan, Bishnu Prasad Marasini 0000-0001-6153-5234 and Jhashanath Adhikari Subin
 

Schematic showing compounds present in Psidium guajava and graphics of the associated proteins that were evaluated against neurodegenerative disorders.

The compounds present in Psidium guajava L. were evaluated against three different proteins (PDB ID: 4A79, 7E3H, 7F61) associated with the regulation of neurodegenerative diseases. Using a computational approach, these compounds were tested for their capability to inhibit the proteins. The resultssupport the potential of P. guajava compounds in managing neurodegenerative disorders. (Image credit: the authors.)

CH24117 Abstract  |  CH24117 Full Text  | CH24117PDF (2.1 MB)  | CH24117Supplementary Material (588 KB)   Open Access Article

Published online 04 June 2025

CH25006closo-Borate aryliodonium zwitterions: convenient intermediates for functional closo-borane derivatives and molecular materials

Piotr Kaszynski 0000-0002-2325-8560
 

Schematic of the functionalization of closo-borates through aryliodonium zwitterions.

This review summarizes the formation, structure, stability and reactions of aryliodonium zwitterions of closo-borate anions. The zwitterions are formed by regioselective aryliodination of closo-borates with ArIII reagents and undergo efficient reactions with nucleophiles. Therefore, this tandem of reactions represents an effective regioselective activation of the B–H bonds in closo-borates towards nucleophilic substitution. (Image credit: Piotr Kaszyński.)

CH25006 Abstract  |  CH25006 Full Text  | CH25006PDF (4 MB)   Open Access Article

Published online 12 May 2025

CH24160Synthesis and anti-hepatic fibrosis activity of novel matrine tricyclic derivatives

Yongchuang Wang, Hang Yang, Wenming Tang, Luozhu Zhou, Chuanhao Wang, Anhua Huang, Daozuan Zhang, Zheng Yao, Wei Li, Wannian Zhang, Yuelin Wu, Weiheng Xu and Zhenyuan Miao 0000-0001-7839-4183
 

Structure of matrine and its tricyclic derivative alongside its effect on TGF-β1-induced expression of collagen I and α-SMA in LX-2 cells.

Novel matrine tricyclic derivatives have been designed and synthesised by a molecular fusion strategy. The most active compound ZM842 indicated potent inhibitory TGF-β transcriptional activity in a dose-dependent manner by downregulating collagen I and α-SMA protein. (Image credit: Yongchuang Wang.)

CH24160 Abstract  | PDF (1.5 MB) - $35.00   | CH24160Supplementary Material (2.8 MB)
Published online 12 May 2025

CH25002Ionic liquid-assisted synthesis of pyrrole derivative: a green and sustainable method

Vaishali, Shubham Sharma 0000-0002-9657-6623, Preeti Jain, Ankush Thakur, Sobhi M. Gomha and Swati Rani
 

Synthesis of tether and fused pyrrole derivatives using ionic liquids as solvent and catalyst from 2001 to 2024.

Green synthesis is garnering global interest among researchers due to its distinctive characteristics and ecological advantages. Researchers are developing innovative ionic liquids (ILs) and enhancing their characteristics for application in green chemistry and synthesis, including environmentally friendly solvents and catalysts. They have been extensively used as green catalysts and solvent systems for the synthesis of many important heterocycles because of their distinctive features. (Image credit: Shubham Sharma.)

CH25002 Abstract  | PDF (3 MB) - $35.00 
Published online 12 May 2025

CH24163Ring-expansion reactions of Cyrene and derivatives with ethyl diazoacetate

Johannes Puschnig, Oscar Lamb, Christopher J. Sumby and Ben W. Greatrex 0000-0002-0356-4966
 

Reaction scheme for the ring-expansion of Cyrene with ethyl diazoacetate and subsequent decarboxylation.

Levoglucosenone and the reduced analogue Cyrene are versatile chiral intermediates for synthesis, available from the cellulose fraction of biomass by acid-catalysed pyrolysis. An ethyl diazoacetate mediated ring expansion has been developed for Cyrene, and combination with a decarboxylation has resulted in homologated ring-systems. Some selected reactions for the first homologated ring-system were then investigated. (Image credit: Ben Greatrex.)

CH24163 Abstract  |  CH24163 Full Text  | CH24163PDF (909 KB)  | CH24163Supplementary Material (2 MB)   Open Access Article

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These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.

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Collections

Collections are a curation of articles relevant to a topical research area

70th Birthday tribute to Professor David Craik

This collection presents papers submitted as a tribute to Professor David Craik on the occasion of his 70th birthday.

Guest Editors
Prof. Ed Nice (Monash University), Prof. Mibel Aguilar (Monash University) & Prof. John Wade (The Florey)

Last Updated: 29 Aug 2025

Beckwith Review Series

Beckwith Reviews honour the memory of Professor Athelstan (Athel) L. J. Beckwith, a remarkable man and an outstanding chemist. These invited reviews advance knowledge in current key areas of research in chemistry.

Last Updated: 04 Jun 2025

10th Anniversary Collection of RACI and AAS Award papers

This collection presents papers submitted by 2023–24 Australian Academy of Science and Royal Australian Chemical Institute Award winners.

All papers in this collection are Open Access and the foreword by the Guest Editor, Curt Wentrup of the School of Chemistry and Molecular Biosciences at The University of Queensland, is free to read.

Last Updated: 10 Oct 2024

Primer Review Series

Primer Reviews are concise, authoritative overviews of important contemporary topics in the chemical sciences. They should appeal to advanced undergraduates, the general research chemist who is new to the field, as well as the expert. They provide a solid introduction to the development of a subject, the latest breakthrough results and their implications for the wider scientific community.

Last Updated: 12 Sep 2024

Cornforth Review Series

Cornforth Reviews honour the memory of Sir John Warcup Cornforth (usually known as Kappa to friends and colleagues). These invited reviews advance knowledge in current key areas of research in chemistry.

Last Updated: 22 Aug 2024

The Medicinal Chemistry Collection

Australian Journal of Chemistry is approaching its eighth decade of publishing key work across many spheres of chemistry, both national and international. As the current co-editors-in-chief, we are delighted to introduce this collection that highlights a selection of the finest recent articles in medicinal chemistry. We are proud to also highlight the significant contributions to medicinal chemistry research made by several outstanding women researchers.

Collection Editors
John Wade and George Koutsantonis

Last Updated: 01 Oct 2020

70 Years of Australian Journal of Chemistry: A Retrospective

This collection reflects the breadth and quality of science published in the Australian Journal of Chemistry by Australian scientists over the last seven decades. Papers were selected based on hard data (citations and downloads), but we also chose papers that reflect other criteria, such as landmarks in important aspects of chemical science; recognition of an influential individual; gender diversity; and simply to reflect the breadth of the journal’s output.

Last Updated: 07 Feb 2019

Nobel Laureates

Australian Journal of Chemistry is proud to have published the works of a number of Nobel prize winners of chemistry. This collection brings together the articles authored by these Nobel prize winners.

Last Updated: 01 Nov 2012

Committee on Publication Ethics

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