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Synthesis of MUC1 Peptide and Glycopeptide Dendrimers
Candy K. Y.
Chun A,
Richard J.
Payne A B
A
School of Chemistry, The University of Sydney, NSW 2006, Australia.
B
Corresponding author. Email: payne@chem.usyd.edu.au
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Australian Journal of Chemistry 62(10) 1339–1343 http://dx.doi.org/10.1071/CH09282
Submitted: 12 May 2009
Accepted: 19 June 2009
Published online: 13 October 2009
Abstract
Several dendrimers possessing multiple copies of peptides and glycopeptides belonging to the MUC1 eicosapeptide tandem repeat sequence have been prepared. Fmoc-strategy solid-phase peptide synthesis was used to construct the peptides and glycopeptides, which were conjugated to suitably functionalized dendrimer cores using the copper-catalyzed azide-alkyne cycloaddition reaction to produce multivalent peptide and glycopeptide dendrimers.
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