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Article << Previous     |     Next >>   Contents Vol 64(6)

Recent Advances in Mapping the Sub-cellular Distribution of Metal-Based Anticancer Drugs

Louise E. Wedlock A B and Susan J. Berners-Price B C

A School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Perth, WA, 6009, Australia.
B Institute for Glycomics, Griffith University, Gold Coast Campus, Qld 4222, Australia.
C Corresponding author. Email: s.berners-price@griffith.edu.au

Australian Journal of Chemistry 64(6) 692-704 http://dx.doi.org/10.1071/CH11132
Submitted: 5 April 2011  Accepted: 8 May 2011   Published: 27 June 2011


 
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Abstract

There are increasing reports of novel metal-based chemotherapeutics that have either improved cancer cell selectivity, or alternative mechanisms of action, to existing anticancer drugs, and techniques are required for determining their sub-cellular molecular targets. Imaging methods offer many distinct advantages over destructive fractionation techniques, including the preservation of useful morphological information; however, mapping the intracellular distribution of metal ions inside tumour cells still remains challenging. Recent advances in three modes of imaging are discussed in this review, with a particular focus on the application to metal-based cancer chemotherapy – fluorescence microscopy, electron microscopy (including energy-filtered transmission electron microscopy (EFTEM)), and a new technique, Nano-scale secondary ion mass spectrometry (NanoSIMS).





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